A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Abstract

Citation for published item: p r elloD it le F nd o ertsD gh rlotte eF nd uerudinD emmielle nd w¤ ullerD omy @PHIUA 9e TSHHEye rEold widdle xeolithi hild from oller g ve @viguri D st lyA with pro le multifo l osteo rti ul r tu er ulosisF9D sntern tion l journ l of p leop thologyFD IU F ppF TUEURF Further information on publisher's website: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

Dating the funerary use of caves in Liguria (northwestern Italy) from the Neolithic to historic times: Results from a large-scale AMS campaign on human skeletal series

“…The individual 2 from Tiné excavations, buried in a simple pit and covered with ochre, had been attributed to early Neolithic based on funerary behavior and stratigraphy (Canci et al, 1999;Tiné, 1976Tiné, , 1986, but the direct date placed it at the end of the fifth millennium BCE (Biagi and Starnini, 2016). More recently, one child from Grotta Pollera was dated to the mid-fifth millennium BCE (Sparacello et al, 2017), and a number of AMS dates on human bone from Arma dell'Aquila highlighted the presence of burials and scattered human remains belonging to the sixth millennium BCE, contemporary with the ICC in Liguria (Mannino et al, 2018;Sparacello et al, 2018bSparacello et al, , 2019 Table 1) (see Table 2).…”

A seventeenth-centuryMycobacterium tuberculosisgenome supports a Neolithic emergence of theMycobacterium tuberculosiscomplex

“…Tuberculosis has left testaments to its history as a human pathogen in the archaeological record (45), and some skeletal evidence has implied the existence of tuberculosis in humans and animals pre-dating the lower 95% HPD boundary for the MTBC MRCA presented here (7,8,10,46–50). However, it is important to explore the evolutionary history of the MTBC through molecular data.…”

Contribution of paleopathology to the knowledge of the origin and spread of tuberculosis: evidence from Portugal

“…These situations are difficult to identify macroscopically and/ or radiologically. Since the 1990s, both hosts and pathogenic agents started to be studied, namely the mycobacterial ancient DNA by polymerase chain reaction (PCR) technique (Donoghue, 2017;Sparacello et al, 2017) and the mycolic acids from mycobacterial cell envelope analyzed by high-performance liquid chromatography (HPLC) (e.g. Redman et al, 2009;Baker et al, 2015).…”