Three-dimensional imaging by spectral domain optical coherence tomography in central serous chorioretinopathy with fibrin

Saxena, Sandeep; Sinha, Neha; Sharma, Swati

doi:10.1007/s12177-012-9087-9

Cited by 8 publications

(7 citation statements)

References 7 publications

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“…The authors commented that RPE morphological irregularities observed on SDOCT-CSLO consistently corresponded to FA leakage sites while similarly the leakage points may occur at any location on the PED [9]. SDOCT imaging of subretinal fibrin leakage that appears to arise from surrounding lateral marginal locations within a PED has been documented by other researchers as well [4,[6][7]. Shinojima and associates also concurred a suggested by other investigators [6,7] that the leakage point may occur at a deteriorating intercellular cell junction consequently generating areas with minute focal fibrin leakage [9].…”

Section: Discussionmentioning

confidence: 74%

“…The advent of OCT technology, leading to higher resolution, allowed imaging of finer microstructure details and variable clinical findings associated with CSC. More current papers have provided detailed descriptions of CSC morphology using SDOCT [1,4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Fujimoto and associates provided a Fourier-domain OCT (FDOCT) analysis of 21 eyes with acute CSC [6].…”

Section: Discussionmentioning

confidence: 99%

“…Although central serours chorioretinopathy (CSC) is typically regarded as idiopathic, it has been associated with a variety of systemic and environmental factors such as hypertension, stress, pregnancy, smoking, elevated cortisol and circulating catecholamines levels [1][2][3][4][5]. The choroid is considered to be principally affected leading to multiple localized tissue damage that precedes focal leakage.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, leakage of serous fluid to the subretinal space results in retinal serous detachment [1][2][3][4][5][6][7][8][9][10][11]. Time domain optical coherence tomography (TDOCT) and spectral domain optical coherence tomography (SDOCT) have significantly facilitated the study and understanding of the pathophysiology and thus, have enhanced the overall management of CSC [1,4,[6][7][8][9][10][11][12][13][14][15][16][17]. Initial observations of patients with CSC using TDOCT revealed associated PED's, sensory retinal elevation and fibrin material accumulation within the areas of damaged RPE [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…In later stages, granular deposits may become more visible at the posterior surface of the detached retina. As the CSC resolves, a decrease in foveal thickness (FT) compared to the unaffected eye has been documented [1,4,6,7,[9][10][11]16].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparative tomography of central serouschorioretinopathy

Besada¹,

Frauens²,

Makhlouf³

et al. 2016

New Front Ophthalmol

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Purpose: To provide spectral domain optical coherence tomography (SDOCT) of subretinal fibrin leakage and concomitant central serous chorioretinopathy (CSC) morphology in four cases. Likewise, to compare the SDOCT of these cases with others documented. Case reports:Four cases of acute onset CSC exhibiting serous neurosensory and retinal pigment epithelium detachment (PED) associated with a hyper-reflective pattern in the subretinal space that appear to emanate from the PED are described. Initially, all cases showed thickening of the photoreceptor outer segment (POS) as well as zones where the inner segment-outer segment junction line (IS/OS) was not visible. All cases had an outer retinal "dipping" appearance. On follow-up visits all cases showed thinning of the POS with an increase of granular deposits on the posterior surface of the detached retina. As the CSC resolved, the IS/OS junction line became visible and the granular deposits diminished. One case exhibited a relative decrease in foveal thickness compared to the unaffected eye. Conclusion:SDOCT imaging of a hyper-reflective pattern at the subretinal space proximal to a PED in CSD may reflect resonance detection of fluid turbulences and density distribution disparities. This occurs as the serous fluid from the choroidal circulation diffuses into the subretinal space from a focal PED leakage site. A clear hypo-reflective area at the core of the hyper-reflective pattern may result from the distribution of less dense constituents centrally while hyper-reflective denser particles surround and concentrate at the peripheral border. The size of the leakage defect in the PED may determine the outline of the hyper-reflective pattern while the location may influence the spatial orientation. The POS swelling may impart pliability to the outer retina. The hydrostatic and fibrin particle pressure flowing from a PED on this retinal layer may contribute to the apparent outer retinal "dipping" imaged on optical coherence tomography.

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