Ocular diseases in metastatic cutaneous melanoma: review of 108 consecutive patients in two German tertiary centers

Grajewski, Rafael S.; Schuler‐Thurner, Beatrice; Mauch, Cornelia; Kreuzberg, Nicole; Koch, Konrad R.; Bergua, Antonio; Cursiefen, Claus; Heindl, Ludwig M.

doi:10.1007/s00417-013-2563-5

Cited by 21 publications

(12 citation statements)

References 25 publications

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“…AEPVM is characterized by multifocal, yellow-white, subretinal lesions associated with serous retinal detachments. These lesions are similar to the vitelliform deposits of Best disease, although genetic testing is negative for BEST1 mutations [131, 132]. FAF shows intense hyper-autofluorescence of the subretinal vitelliform material, which tends to gravitate inferiorly [133].…”

Section: Macular Dystrophiesmentioning

confidence: 99%

Clinical applications of fundus autofluorescence in retinal disease

2016

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Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Multiple commercially available imaging systems, including the fundus camera, the confocal scanning laser ophthalmoscope, and the ultra-widefield imaging device, are available to the clinician. Each offers unique advantages for evaluating various retinal diseases. The clinical applications of FAF continue to expand. It is now an essential tool for evaluating age related macular degeneration, macular dystrophies, retinitis pigmentosa, white dot syndromes, retinal drug toxicities, and various other retinal disorders. FAF may detect abnormalities beyond those detected on funduscopic exam, fluorescein angiography, or optical coherence tomography, and can be used to elucidate disease pathogenesis, form genotype-phenotype correlations, diagnose and monitor disease, and evaluate novel therapies. Given its ease of use, non-invasive nature, and value in characterizing retinal disease, FAF enjoys increasing clinical relevance. This review summarizes common ocular fluorophores, imaging modalities, and FAF findings for a wide spectrum of retinal disorders.

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Section: Macular Dystrophiesmentioning

confidence: 99%

Clinical applications of fundus autofluorescence in retinal disease

2016

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“…The primary concern in our opinion is when a patient is diagnosed with acute exudative polymorphous vitelliform maculopathy, a paraneoplastic component should be immediately ruled out. There have been cases described in the literature that have been associated with cutaneous melanoma, breast, testicular and lung carcinoma 8. It is imperative that malignancy be ruled out and specialist opinion, particularly oncology, be sought.…”

Section: Discussionmentioning

confidence: 99%

Acute Exudative Polymorphous Vitelliform Maculopathy Syndrome; natural history and evolution of fundal and OCT images over time

Murtagh¹,

Treacy

Stephenson

et al. 2018

BMJ Case Reports

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A 33-year-old man presented with a 10-day history of bilateral blurred vision on a background of a prodromal influenza-like illness. Ocular Coherence Tomography (OCT) and fundal examination coincided with a diagnosis of atypical central serous retinopathy. The patient's symptoms worsened during follow-up, and he was started on steroids. Subsequent fundal examination revealed yellow deposits in a honeycomb pattern and hard exudates in the perimacular region. Serial OCTs revealed progression of bilateral macular intraretinal and subretinal fluid. He was subsequently admitted to hospital for a full paraneoplastic workup. Liaison with our colleagues in other specialist retinal centres led us to a diagnosis of acute exudative polymorphous vitelliform maculopathy syndrome. We subsequently took fundal images to monitor disease progression and to monitor changes seen with autofluorescence in this rare disease entity.

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“…Early recognition leads to quicker identification of a primary site and appropriate expedited treatment of the disease. Unfortunately, information about eye conditions associated with metastatic melanoma patients still relies on the collection of scattered case reports [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

Exudative Polymorphous Vitelliform Retinopathy: Importance of Early Recognition of the Condition in Patients with Metastatic Melanoma

et al. 2016

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IntroductionBecause of the advent of monoclonal antibodies in the treatment of metastatic melanoma, patients with this disease are surviving longer. Early recognition of the disease has therefore become even more important.Case reportWe present a patient with vitelliform maculopathy, a paraneoplastic retinal maculopathy that is under-recognized. Clinically the retinal findings of serous detachments and pigmentary macular changes are remarkable, while at the same time these patients have surprisingly very few symptoms. This is in contrast to patients who develop melanoma associated retinopathy (MAR) who are very symptomatic early in the disease, but with more subtle retinal findings.ConclusionMonoclonal antibody treatment is changing the survival rates in metastatic disease making early diagnosis even more important. Exudative polymorphous vitelliform maculopathy (EPVM) needs to be recognized early to avoid delay in diagnosis of metastatic disease.

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Ocular diseases in metastatic cutaneous melanoma: review of 108 consecutive patients in two German tertiary centers

Abstract: Patients with metastatic cutaneous melanoma reveal ocular diseases with a spectrum similar to the normal population of this age range. Very rarely, uveal metastasis as well as paraneoplastic retinopathy can occur.

Cited by 21 publications

References 25 publications

Clinical applications of fundus autofluorescence in retinal disease

Clinical applications of fundus autofluorescence in retinal disease

Acute Exudative Polymorphous Vitelliform Maculopathy Syndrome; natural history and evolution of fundal and OCT images over time

Exudative Polymorphous Vitelliform Retinopathy: Importance of Early Recognition of the Condition in Patients with Metastatic Melanoma

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