Three-dimensional High-speed Optical Coherence Tomography Imaging of Lamina Cribrosa in Glaucoma

Inoue, Ryo; Hangai, Masanori; Kotera, Yuriko; Nakanishi, Hideo; Mori, Satoshi; Morishita, Shiho; Yoshimura, Nagahisa

doi:10.1016/j.ophtha.2008.09.008

Cited by 143 publications

(96 citation statements)

References 24 publications

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“…[13][14][15][16] 3D SD-OCT imaging demonstrated thinning and posterior displacement of the lamina cribrosa, consistent with earlier histopathological findings. 14,16 SD-OCT technology also allows enhanced depth imaging (EDI), which improves visualization of the deep fundus structures including the lamina cribrosa. [17][18][19] Recently, the EDI-OCT method was successfully used in the discovery of a local abnormality of lamina cribrosa, termed focal lamina cribrosa defect, which was associated with local glaucomatous optic disc changes such as neuroretinal rim thinning/notching or acquired pits of the optic nerve (APONs).…”

supporting

confidence: 80%

“…Spectral domain optical coherence tomography (SD-OCT) allows 3D imaging of the lamina cribrosa and laminar pores. [13][14][15][16] 3D SD-OCT imaging demonstrated thinning and posterior displacement of the lamina cribrosa, consistent with earlier histopathological findings. 14,16 SD-OCT technology also allows enhanced depth imaging (EDI), which improves visualization of the deep fundus structures including the lamina cribrosa.…”

supporting

confidence: 78%

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Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Takayama

Hangai

Kimura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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confidence: 80%

supporting

confidence: 78%

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Takayama

Hangai

Kimura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…[34][35][36][37] Some investigations have attempted to measure the anterior and posterior borders of the lamina by spectral-domain OCT (SD-OCT), suggesting a thinner lamina in glaucoma eyes. [38][39][40][41] Indeed, the lamina is thinner in damaged glaucoma eyes by scanning electron microscopy. 42 However, the posterior lamina border is difficult to identify in OCT images, 43 whereas the position of the anterior lamina provides a recognizable, contrasting border that delineates it from the prelaminar tissues, which consist mostly of axons and astrocytes.…”

mentioning

confidence: 97%

Biomechanical Responses of Lamina Cribrosa to Intraocular Pressure Change Assessed by Optical Coherence Tomography in Glaucoma Eyes

Quigley

Arora

Idrees

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to measure change in anterior lamina cribrosa depth (ALD) globally and regionally in glaucoma eyes at different intraocular pressures (IOP).METHODS. Twenty-seven glaucoma patients were imaged before and after IOP-lowering procedures using optical coherence tomography. The anterior lamina was marked in approximately 25 locations in each of six radial scans to obtain global and regional estimates of ALD. ALD and its change with IOP were compared with optic disc damage, nerve fiber layer thickness, and visual field loss. RESULTS.Variables associated with deeper baseline ALD included larger cup/disc ratio, thinner rim area, larger cup volume, thinner central corneal thickness, and male sex (all P 0.02). When IOP was lowered, ALD position became more anterior, more posterior, or was unchanged. The mean ALD change after lowering was 27 6 142 lm (P ¼ 0.3). The mean absolute value of ALD change was 112 6 90 lm (P ¼ 0.002). Change in ALD was greater in eyes with lower IOP in paired comparisons (P ¼ 0.006) but was not associated with the magnitude of IOP lowering between imaging sessions (P ¼ 0.94). Eyes with no significant change in ALD tended to have more visual field loss than those with significant anterior ALD displacement (P ¼ 0.07). Areas within each optic nerve head that corresponded to zones with thicker nerve fiber layer had greater ALD positional change (P ¼ 0.0007).CONCLUSIONS. The lamina can move either anteriorly or posteriorly with IOP decrease, with greater displacement at lower IOP. Glaucoma eyes and regions within glaucoma eyes associated with greater glaucoma damage exhibited smaller responses.Keywords: glaucoma, lamina cribrosa, optic nerve head, optical coherence tomography, intraocular pressure, biomechanics, stress A major site of damage to retinal ganglion cell (RGC) axons in glaucoma is the optic nerve head (ONH), within the lamina cribrosa.1-3 The biomechanical transmission of stress from intraocular pressure (IOP) produces strain in both the sclera and the ONH, 4-6 generating detrimental effects on RGC axons, ONH astrocytes, and nutritional blood flow in the nerve head. 7 The IOP level that produces RGC loss can be variable among individuals; some eyes suffer damage at IOPs that would be considered normal based on population studies, whereas many eyes with elevated IOP suffer no detectable damage. This suggests that the short-and long-term responses of scleral and ONH connective tissues to changes in IOP represent possible biomarkers for glaucoma incidence and progression. Normal lamina cribrosa structure is remodeled in glaucoma eyes, becoming deeper and wider 8 under the influence of a variety of factors, notably the stress of IOP as delivered through the sclera. 9 The regional differences in connective tissue density and pore size within the lamina cribrosa and greater regional strains suggest that the upper and lower poles of the ONH are weaker at resisting the stress of IOP in both human 10-14 and nonhuman primate eyes. 15 Indeed, these regions contain...

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“…The LC is a network of connective tissue beams that provide structural and nutritional support to the RGC axons [1, 9]. ALCSD has been positively correlated with untreated IOP in POAG eyes [19], while LCT has been positively correlated with VF MD or peripapillary RNFL thickness [20-22]. Here, higher IOP, lower MD, and thinner RNFL thickness were associated with a deeper and thinner LC.…”

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confidence: 99%

Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters

et al. 2019

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Purpose: To measure lamina cribrosa thickness (LCT) and anterior lamina cribrosa surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic primary angle-closure glaucoma (CPACG), and control patients using spectral-domain optical coherence tomography (SD-OCT) and examine its association with relevant ocular parameters. Methods: In this cross-sectional study, 61 healthy volunteers (61 eyes), 65 POAG patients (65 eyes), and 55 CPACG patients (55 eyes) were recruited to obtain radial B-scans of the optic nerve head by way of enhanced depth imaging using Heidelberg SD-OCT. The obtained LCT and ALCSD were compared among the control, POAG, and CPACG groups. In addition, we evaluated the relationships of mean lamina cribrosa (LC) parameters with visual field (VF) mean deviation (MD), retinal nerve fiber layer (RNFL) thickness, intraocular pressure (IOP), and axial length. Results: The mean LCT of CPACG eyes was greater than that of POAG eyes (p = 0.003), but less than that of normal eyes (p < 0.001). The mean ALCSD of POAG and CPACG eyes was greater than that of normal control eyes (both p < 0.001). However, the mean ALCSD showed no significant difference between the POAG and CPACG groups (p = 0.073). Among all eyes, lower MD and thinner RNFL thickness were associated with a deeper and thinner LC (all p < 0.001). Conclusion: LCT is thinner in POAG compared to CPACG eyes. This is compatible with less deformation and compression of the LC in CPACG eyes, implying that the mechanisms of glaucomatous damage are different between POAG and CPACG eyes. Furthermore, VF MD and RNFL thickness were related to LCT and ALCSD in all patients.

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Three-dimensional High-speed Optical Coherence Tomography Imaging of Lamina Cribrosa in Glaucoma

Abstract: The authors have no proprietary or commercial interest in any materials discussed in this article.

Cited by 143 publications

References 24 publications

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Biomechanical Responses of Lamina Cribrosa to Intraocular Pressure Change Assessed by Optical Coherence Tomography in Glaucoma Eyes

Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters

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