Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters

Liu, Hao; Xiao, Hui; Gao, Xue; Xu, Xiaoyu; Xing, Liu

doi:10.1159/000496558

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…In our study cases revealed significant LC thinning as compared to controls, and similar results have also been proposed by Hao et al 16 in which LC thinning had been detected in POAG and primary angle closure glaucoma patients. Park et al also expounded that LC irregularities correlate with the RNFL thinning in POAG subjects.…”

Section: Visual Field Defects In Primary Open Angle Glaucomasupporting

confidence: 92%

Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma

et al. 2020

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Objectives: To calculate the anterior lamina cribrosa depth (ALCD) and lamina cribrosa thickness (LCT) in primary open angle glaucoma (POAG) patients and controls and to correlate lamina cribrosa (LC) parameters to retinal nerve fiber layer thickness (RNFLT) and visual field (VF) defects. Methods: The study was conducted from November 2018 to March 2019. A total of 60 correspondents (30 cases and 30 controls) were assessed for general ophthalmological investigations including intraocular pressure (IOP), axial length AXL, ophthalmoscopy, visual field (VF) testing and spectral domain ocular computed tomography (SDOCT). Results: The mean age of subjects was 62 years (Cases 67.30±1.2, controls 57.32±1.1) with more male participants. Intraocular pressure [IOP (19.85 ±1.4)], AXL (22.85 ± 1.6), VF defects (8.30 ± 4.5), RNFLT (72.58 ± 13.2) and LCT (162.51 ± 64.62) were statistically significant in POAG patients as compared to the controls. Conclusion: A thinner LC in POAG correlated significantly with the RNFLT and VF defects. LC anatomical parameters can be estimated with precision using SDOCT with enhanced depth imaging (EDI). doi: https://doi.org/10.12669/pjms.36.3.1553 How to cite this:Naz AS, Qamar A, Sama-Ul-Haque, Zaman Y, Faheem F. Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1553 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Visual Field Defects In Primary Open Angle Glaucomasupporting

confidence: 92%

Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma

et al. 2020

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“…The inclusion criteria for all subjects were (1) a diagnosis of advanced primary open-angle glaucoma (POAG) or chronic primary angle-closure glaucoma (CPACG) based on a 24-2 VF MD of ≤−12 dB, (2) age ≥18 years, (3) a BCVA of at least 20/50, and (4) a spherical refraction of −6.0 to +3.0 diopters and cylinder correction within ±3.0 diopters. POAG was diagnosed in patients with a glaucomatous VF defect in 2 consecutive reliable VF examinations, typical glaucomatous optic neuropathy (i.e., neuroretinal rim thinning, notching, or an RNFL defect), open angles on gonioscopy, and a confirmed untreated IOP >21 mm Hg [32, 33]. Glaucomatous VF defects were defined as a cluster of 3 or more nonedge contiguous points on a pattern deviation plot at the p < 5% level (with at least 1 point depressed at the p < 1% level) confirmed in at least 2 consecutive examinations, a pattern standard deviation (PSD) at the p < 5% level, or a glaucoma hemifield test result outside normal limits [34].…”

Section: Methodsmentioning

confidence: 99%

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

et al. 2020

Ophthalmic Res

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Purpose: To evaluate the associations of optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer thickness (mGCIPLT), circumpapillary retinal nerve fiber layer thickness (cpRNFLT), and optic nerve head (ONH) parameters with visual field (VF) sensitivity in advanced glaucoma. Methods: In this cross-sectional study, 102 eyes from 102 patients with advanced glaucoma (defined as a 24-2 VF mean deviation (MD) of ≤−12 dB) were included. mGCIPLT, cpRNFLT, and ONH parameters (including the rim area, average cup-to-disc [C:D] ratio, and vertical C:D ratio) were measured using Cirrus high-definition OCT, and 24-2 and 10-2 VF sensitivity tests were performed using standard automated perimetry. Pearson correlations and linear models were used to analyze relationships between OCT-derived parameters and VF parameters. Results: The mGCIPLT and rim area were significantly positively correlated with the 24-2 VF MD, 24-2 VF pattern standard deviation, 24-2 VF visual field index, and 10-2 VF MD, but cpRNFLT was not significantly correlated with VF parameters. In addition, the average and vertical C:D ratios were significantly negatively correlated with VF parameters. The mGCIPLT and rim area were significantly positively correlated with the 10-2 VF MD (r ranging between 0.542 and 0.621, p < 0.001), while the average and vertical C:D ratios were significantly negatively correlated with the 10-2 VF MD (r = −0.537, p < 0.001, and r = −0.428, p < 0.001, respectively). Each 1-µm change in the average mGCIPLT was associated with an approximately 0.368-dB change in the 24-2 VF MD and 0.677-dB change in the 10-2 VF MD (R² = 0.268, p < 0.001, and R² = 0.385, p < 0.001, respectively). The 10-2 VF MD showed a significantly stronger association with inferonasal mGCIPLT than did the 24-2 VF MD in advanced glaucoma (p = 0.007). Conclusions: mGCIPLT and ONH parameters were associated with the severity of VF damage and reflected functional damage better than cpRNFLT in advanced glaucoma. Our results suggested that structural measurements of mGCIPLT and ONH parameters and functional measurement of the 10-2 VF may be useful for monitoring progression in advanced glaucoma.

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“…Regarding the effect of changes in LC and consequently TLPG, it was reported that in eyes with glaucoma, a deeper and thinner LC (which increases TLPG) is associated with a thinner retinal nerve ber layer (RNFL, which consists of RGCs and their axons). 12,36 Another study stated a signi cant association between thinner LC and a faster rate of RNFL thinning in primary open-angle glaucoma. 37 The effects of SO on retinal layers have been investigated in several studies.…”

Section: Discussionmentioning

confidence: 99%

“…6,8,9 LC thinning and posterior displacement are considered to be associated with optic neuropathy and subsequent visual impairment via the disruption of axoplasmic ow within the optic nerve. [10][11][12][13] In this study, our objective is to investigate changes in thickness and depth of LC in patients who underwent pars plana vitrectomy (PPV) and received SO as the treatment method compared to their fellow eyes.…”

Section: Introductionmentioning

confidence: 99%

Lamina Cribrosa Changes following Pars Plana Vitrectomy and Silicone Oil Injection for Rhegmatogenous Retinal Detachment: A contralateral Eye Study

Nikkhah,

Eshtahbanati,

Hooshmandi

et al. 2023

Preprint

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Purpose To assess changes in lamina cribrosa (LC) characteristics in eyes with silicone oil (SO) due to rhegmatogenous retinal detachment (RRD). Method This cross-sectional contralateral eye study was conducted on 49 patients with unilateral RRD who underwent pars plana vitrectomy and SO injection. The contralateral eyes served as controls. Thickness and depth of LC of both eyes of the participants were evaluated using enhanced depth imaging technique via optical coherence tomography. Results The average age of the participants was 57.6 ± 10.5 years and the mean duration of post-op SO retainment was 1.7 ± 6.4 months. The mean LCD in eyes with SO tamponade was 347.6 ± 64.3 µm, whereas, in healthy eyes, it was 329.6 ± 76.7 µm (P = 0.232). On the other hand, the LC in eyes with SO tamponade was significantly thinner compared to that in healthy eyes (270.1 ± 45.1 µm and 303.2 ± 48.6 µm, respectively) (P < 0.0001). Subgroup analysis revealed that after excluding patients who were underwent anti-glaucoma medications, similar findings was resulted. Conclusion We showed that eyes with silicone oil exhibit a significantly thinner LC compared to healthy eyes, with no difference in the depth of the LC between the two groups.

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Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters

Cited by 8 publications

References 41 publications

Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma

Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

Lamina Cribrosa Changes following Pars Plana Vitrectomy and Silicone Oil Injection for Rhegmatogenous Retinal Detachment: A contralateral Eye Study

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