Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring

Wang, Xiahua; Liu, Aiping; Xing, Yun; Duan, Hongwei; Xu, Weizhong; Zhang, Qi; Wu, Huaping; Chen, Cen; Chen, Benyong

doi:10.1016/j.bios.2018.01.012

Cited by 56 publications

(44 citation statements)

References 58 publications

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“…Ali et al [75] fabricated a microfluidic immunosensor to detect breast cancer molecules utilizing a graphene foam modified electrode. A 3D biointerface of graphene-based electrical impedance sensor was fabricated by Wang et al [76] for the diagnosis of metastatic cancer. Inoue et al [77] fabricated graphene-based inline pressure sensor integrated with microfluidic elastic tube which can be used for accurate pressure measurement in microfluidic systems including organ-on-a-chip devices.…”

Section: Point Of Care Analysismentioning

confidence: 99%

Graphene and its derivatives for Analytical Lab on Chip platforms

Sengupta

Hussain

2019

TrAC Trends in Analytical Chemistry

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a b s t r a c tSince last decade, graphene has materialized itself as one of the phenomenal materials to modern researchers because of its remarkable thermal, optical, electronic, and mechanical properties. Graphene holds enormous potentials for lab on chip (LOC) devices and can provide diverse fabrication routes and structural features due to their special electronic and electrochemical properties. A LOC device can manipulate fluids using microchannels and chamber structures, to accomplish fast, highly sensitive and inexpensive analysis with high yield. Hence, the graphene based LOC devices can constitute a wellcontrolled microenvironment for both advanced chemical/biological evaluation and low-cost point-ofcare analysis etc. This review critically debates the graphene as a prime candidate for microfluidic devices and their future applicability towards various practical applications. Finally, the opportunities and challenges for the future of graphene with respect to their commercial challenges and sustainability perspectives are discussed.

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Section: Point Of Care Analysismentioning

confidence: 99%

Graphene and its derivatives for Analytical Lab on Chip platforms

Sengupta

Hussain

2019

TrAC Trends in Analytical Chemistry

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“…Other groundbreaking sensing strategies are presently focused on biomedical devices able to meticulously detect cancer cells 47, 48 . One example was reported by Wang et al 49 , who fabricated a 3D graphene biointerface capable of using its irregular and conductive surface to enhance the formation of filopodia from the cells due to the established multidimensional cell-material interactions. Then, by combining these topographical features with the potential of graphene to be used as an electrode material, it was possible to upgrade the recognition of the electrical impedance signals coming from cancer cells (relative to the cell capture and sensing efficiencies) with respect to standard 2D gold interfaces.…”

Section: Gbm In Diagnostics and Healthcare Monitoringmentioning

confidence: 99%

Do biomedical engineers dream of graphene sheets?

et al. 2019

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“…Sui et al integrated a 3D graphene biointerface on the microfluidic chip to single cancer cell monitoring. Simultaneous CCD recording and electrical signal extraction from the entrapped single cell on the graphene biointerface enabled them to investigate multidimensional cell–electrode interactions and predict cancerous stage and pathology . Figure shows the chip and experimental results.…”

Section: Application Of Graphene‐based Microfluidicsmentioning

confidence: 99%

A review on application of graphene‐based microfluidics

Chen

Zhang

Han

et al. 2018

J of Chemical Tech & Biotech

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This review reports on the progress of recent developments in graphene-based microfluidics. The applications of graphene-based microfluidics that are the focus of this work are illustrated and discussed mainly with examples from detection of viruses and disease, detection of proteins and glucose, detection of contaminants, and applications in sensors and material preparation. A variety of microfluidic devices integrated with graphene are expounded and analysed. This paper will provide an expedient and valuable reference to designers researching graphene-based microfluidics for various applications.Graphene-based microfluidics for other microfluidic devices Sui et al. described a novel microfluidic platform for use in electrocrystallization experiments. The device incorporated ultra-thin graphene-based films as electrodes and as X-ray

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Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring

Cited by 56 publications

References 58 publications

Graphene and its derivatives for Analytical Lab on Chip platforms

Graphene and its derivatives for Analytical Lab on Chip platforms

Do biomedical engineers dream of graphene sheets?

A review on application of graphene‐based microfluidics

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