Three Dimensional functional MRI in schizophrenics and normal volunteers performing the Wisconsin card sorting test

Kotrla, Kathryn J.; Mattay, V.S.; Duyn, Jeff H.; Gelderen, Peter van; Jones, D; Barrios, Fernando A.; Sexton, Roy H.; Moonen, C.; Frank, Josef; Weinberger, D.R.

doi:10.1016/0006-3223(94)90687-4

Cited by 3 publications

(2 citation statements)

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“…The most incontrovertible evidence that patients with schizophrenia are neurologically and cognitively abnormal during childhood comes from two prospective epidemiological studies of British birth cohorts (Jones et al 1994 andDone et al 1994). Cognitive and social deficits as well as delayed neuromotor milestones during infancy and childhood were associated with the diagnosis of schizophrenia during adulthood.…”

Section: How Conclusive Is Evidence Of Developmental Neuropathology?mentioning

confidence: 99%

“…Recent studies using the novel functional neuroimaging approach available with MRI (socalled fMRI), where cortical activation patterns can be appreciated in individual cases without grouping subjects as is standard procedure with nuclear medicine techniques, also suggest that "hypofocality" is a more general feature of the schizophrenic cortex. In two preliminary reports with fMRI, patients with schizophrenia tend to manifest similar unfocused overactivation of nonmotor cortex during simple finger movements (Wenz et al 1993;Kotrla et al 1994). NEUROPSYCHOPHARMACOLOGY 1996-VOL.…”

Section: Does Evidence Of Neurofunctional Abnormalities Relate To Thementioning

confidence: 99%

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On the Plausibility of “The Neurodevelopmental Hypothesis” of Schizophrenia

Weinberger

1996

Neuropsychopharmacology

219

133

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Speculation that schizophrenia is associated with abnormal brain development, the so-called neurodevelopmental hypothesis, has become so popular that it is rarely challenged in the literature. This paper critically examines the evidence for this hypothesis, taking primarily the "devil's advocate" position. The evidence from neuroimaging studies, from studies of prenatal and perinatal intrauterine events and of premorbid development are circumstantial with respect to brain development, many studies are methodologically flawed, and most do not exclude alternative explanations. Evidence from postmortem studies of anomalous cytoarchitecture in limbic and prefrontal cortices is especially noteworthy, as a developmental defect is virtually certain if artifacts can be excluded. Unfortunately, the studies responsible for these findings have serious methodological limitations. The neurobiological plausibility of the hypothesis, which might have been predicted to be its weakest aspect, has proved surprisingly unshakeable in a recent series of animal studies. Ironically, the principal weakness of the neurodevelopmental hypothesis at present is the clinical database on which it rests.

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Section: How Conclusive Is Evidence Of Developmental Neuropathology?mentioning

confidence: 99%

Section: Does Evidence Of Neurofunctional Abnormalities Relate To Thementioning

confidence: 99%

On the Plausibility of “The Neurodevelopmental Hypothesis” of Schizophrenia

Weinberger

1996

Neuropsychopharmacology

219

133

View full text Add to dashboard Cite

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fMRI and cognitive dysfunction in schizophrenia

Mitchell

Elliott

Woodruff

2001

Trends in Cognitive Sciences

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Brain Imaging in Schizophrenia

Kotrla

Weinberger

1995

Annu. Rev. Med.

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Neuroimaging provides an unprecedented means by which to study psychiatric disorders. Structural imaging methods, i.e. computerized tomography (CT) and magnetic resonance imaging (MRI), have revealed subtle differences in the brains of schizophrenic patients that appear to be present before symptom onset. Radionuclide functional methods such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) have led to hypotheses about dysfunction in specific neuronal networks in schizophrenia. New advances in MRI allow functional data to be obtained noninvasively in a single individual using conventional MRI scanners. This chapter discusses the parallels between the historical technical developments in neuroimaging and the deepening understanding of the etiology and manifestations of schizophrenia.

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Three Dimensional functional MRI in schizophrenics and normal volunteers performing the Wisconsin card sorting test

Cited by 3 publications

References 0 publications

On the Plausibility of “The Neurodevelopmental Hypothesis” of Schizophrenia

On the Plausibility of “The Neurodevelopmental Hypothesis” of Schizophrenia

fMRI and cognitive dysfunction in schizophrenia

Brain Imaging in Schizophrenia

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