fMRI and cognitive dysfunction in schizophrenia

Mitchell, Rachel L.C.; Elliott, Richard M.; Woodruff, Peter

doi:10.1016/s1364-6613(00)01599-0

Cited by 55 publications

(26 citation statements)

References 37 publications

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“…Those patients with schizophrenia, who are prone to auditory hallucinations, have been reported to show right hemisphere hypo-activity that is implicated in aberrant verbal self-monitoring [5]. The present results are in accordance with the evidence for abnormal hemispherical laterality in schizophrenia, which has been reported by recent fMRI studies on various language tasks [6].…”

Section: Discussionsupporting

confidence: 93%

Functional MRI study on neural network dysfunction in schizophrenia and epileptic psychosis

Fukumoto

Matsushima

Matsuda

et al. 2004

International Congress Series

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Section: Discussionsupporting

confidence: 93%

Functional MRI study on neural network dysfunction in schizophrenia and epileptic psychosis

Fukumoto

Matsushima

Matsuda

et al. 2004

International Congress Series

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“…For example, structural findings only weakly and inconsistently correlate with the clinical and cognitive symptoms of schizophrenia [26]. Similarly, functional experiments report deficits in many cognitive domains, most notably memory and attention, but do not consistently identify clinical correlates [27]. …”

Section: Prior Workmentioning

confidence: 99%

From Connectivity Models to Region Labels: Identifying Foci of a Neurological Disorder

Venkataraman

Kubicki

Golland

2013

IEEE Trans. Med. Imaging

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We propose a novel approach to identify the foci of a neurological disorder based on anatomical and functional connectivity information. Specifically, we formulate a generative model that characterizes the network of abnormal functional connectivity emanating from the affected foci. This allows us to aggregate pairwise connectivity changes into a region-based representation of the disease. We employ the variational expectation-maximization algorithm to fit the model and subsequently identify both the afflicted regions and the differences in connectivity induced by the disorder. We demonstrate our method on a population study of schizophrenia.

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“…It is well established that the symptoms of schizophrenia include a range of cognitive deficits that often persist, despite significant improvements in psychotic symptoms following treatment (Goldberg et al, 1993;Mitchell et al, 2001). Pharmacological treatment of cognitive impairment has become an important intervention target in schizophrenia (Hyman and Fenton, 2003).…”

Section: Introductionmentioning

confidence: 99%

Modafinil Improves Cognition and Attentional Set Shifting in Patients with Chronic Schizophrenia

Turner

Clark

Pomarol‐Clotet

et al. 2004

Neuropsychopharmacol

240

172

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Modafinil, a novel cognitive enhancer, selectively improves neuropsychological task performance in healthy volunteers and adult patients with attention deficit hyperactivity disorder (ADHD). It has been argued that persistent cognitive deficits in patients with schizophrenia are responsible for the failure of many patients to rehabilitate socially even when psychotic symptoms are in remission. The present study examined the potential of modafinil as a cognitive enhancer in schizophrenia. Twenty chronic patients with a diagnosis of schizophrenia were entered into a double-blind, randomized, placebo-controlled crossover study using a 200 mg dose of modafinil. Modafinil had some cognitive enhancing properties in schizophrenia similar to those observed in healthy adults and adult patients with ADHD. Improvement was seen on short-term verbal memory span, with trends towards improved visual memory and spatial planning. This was accompanied by slowed response latency on the spatial planning task. No effect on stop-signal performance was seen. Importantly, significant improvement in attentional set shifting was seen, despite no effect of modafinil on this task being seen in healthy volunteers or ADHD patients. Modafinil may have potential as an important therapy for cognitive impairment in patients with schizophrenia, particularly because of its beneficial effects on attentional set shifting.

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fMRI and cognitive dysfunction in schizophrenia

Cited by 55 publications

References 37 publications

Functional MRI study on neural network dysfunction in schizophrenia and epileptic psychosis

Functional MRI study on neural network dysfunction in schizophrenia and epileptic psychosis

From Connectivity Models to Region Labels: Identifying Foci of a Neurological Disorder

Modafinil Improves Cognition and Attentional Set Shifting in Patients with Chronic Schizophrenia

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