Three‐Dimensional Electrospun Alginate Nanofiber Mats via Tailored Charge Repulsions

Bonino, Christopher A.; Efimenko, Kirill; Jeong, Sunho; Krebs, Melissa D.; Alsberg, Eben; Khan, Saad A.

doi:10.1002/smll.201101791

Cited by 163 publications

(130 citation statements)

References 36 publications

(49 reference statements)

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“…10 The use of the surfactant Pluronic F127 facilitated also the emulsification of the essential oil in the aqueous phase, allowing the preparation of stable SA-PEO/LO solutions. This positively affected the morphology of the electrospun nanofibers.…”

Section: Physicochemical Properties Of the Nanofibersmentioning

confidence: 99%

“…In particular, nanofibers produced by electrostatic spinning have high potentiality in the wound healing field because their porosity promotes nutrient transport and gas permeation, their morphological organization mimics the native tissue, and their mechanical properties can be engineered. 5,[9][10][11] The intrinsic high surface area of nanofibers is also attractive for the delivery of drugs and active agents. 2,12 Alginate structures cross-linked with Calcium ions (Ca 2+ ) are mainly used for the treatment of highly exuding wounds and burns.…”

Section: Introductionmentioning

confidence: 99%

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Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

et al. 2016

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This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.You can find more information about Accepted Manuscripts in the Information for Authors. One of the current challenges in wound care is the development of multifunctional dressings that can both protect the wound from external agents and promote the regeneration of the new tissue. Here, we show the combined use of two naturally derived compounds, sodium alginate and lavender essential oil, for the production of bioactive nanofibrous dressings by electrospinning, and their efficacy for the treatment of skin burns induced by midrange ultraviolet radiation (UVB). We demonstrate that the engineered dressings reduce the risk of microbial infection of the burn, since they stop the growth of Staphylococcus aureus. Furthermore, they are able to control and reduce the inflammatory response that is induced in human foreskin fibroblasts by lipopolysaccharides, and in rodents by UVB exposure. In particular, we report a remarkable reduction of pro-inflammatory cytokines when fibroblasts or animals are treated with the alginate-based nanofibers. The down-regulation of cytokines production and the absence of erythema on the skin of the treated animals confirm that the here described dressings are promising as advanced biomedical devices for burn management.

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Section: Physicochemical Properties Of the Nanofibersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

et al. 2016

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“…Furthermore the migration of SA chains due the applied electric field is an additional factor which leads to a new rearrangement for the polymers. As the polymer solution passes through the needle, during the electrospinning process, negatively charged species are attracted to the positively charged electric field on the needle walls [20]. Thus, alginate, a negatively charged polyelectrolyte, is preferentially distributed on the outer surfaces of the electrospun fibers, whereas PEO preferentially remains within the interior.…”

Section: Spinnability Versus Concentration Of Gold Anionsmentioning

confidence: 99%

“…One disadvantage of alginate is that it cannot be electrospun on its own [17][18][19]. Nevertheless, blends of alginate with other polymers, such as polyethylene oxide (PEO) [17], [20], [21], can circumvent this limitation. Furthermore, chemically modification of the alginate nanofibers by incorporation with Au NPs addressing the biomedical usage of the nonwowen mats.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the electro-spinnability of alginate solutions containing gold precursor HAuCl 4

Anyfantis

Hajiali

Mele

et al. 2016

Journal of Colloid and Interface Science

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Alginate nanofibers with an average diameter of 75 nm have been prepared by the electrospinning process. In addition, the spinnability of the solutions in the presence of the gold precursor HAuCl 4 was investigated. At low concentrations of HAuCl 4 well-formed nanofibers were produced, whereas as its concentration increases the nanofibrous mats present an increased number of bead-like defects. Herein, the in situ preparation of gold nanoparticles (Au NPs) is discussed since sodium alginate (SA) acts as the reducing agent and a mechanism is proposed in order to explain the beadeffect as well as the surface morphology of the alginate fibers decorated with Au NPs.

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“…Ambient conditions, temperature and humidity, can also affect the morphology and diameter of the nanofibres [77]. It was deduced that the increase in temperature reduces the viscosity of the solution and enhances the solvent evaporation, which results in thinner nanofibres [89].…”

Section: Ambient Conditionsmentioning

confidence: 99%

A review on electrospun bio-based polymers for water treatment

Mokhena¹,

Jacobs²,

Luyt³

2015

Express Polym. Lett.

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Abstract. Over the past decades, electrospinning of biopolymers down to nanoscale garnered much interest to address most of the millennia issues related to water treatment. The fabrication of these nanostructured membranes added a new dimension to the current nanotechnologies where a wide range of materials can be processed to their nanosize. Electrospinning is a simple and versatile technique to fabricate unique nanostructured membranes with fascinating properties for a wide spectrum of applications such as filtration and others. These nanostructured membranes, fabricated by electrospinning, were found to be of a paramount importance because of their advanced inherited properties such as large surface-to-volume ratio, as well as tuneable porosity, stability, and high permeability. The extensive research conducted on these materials extended the success of electrospinning not only to bio-based polymer nanofibres, but to their hybrids and their derivatives. The technique also created avenues for advanced and massive production of nanofibres. This paper reviews the recent developments in the electrospinning technique. Electrospinning of biopolymers, their blends and functionalization using metals/metal oxides, and the potential applications of electrospun nanofibrous membranes in water filtration are discussed.

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Three‐Dimensional Electrospun Alginate Nanofiber Mats via Tailored Charge Repulsions

Cited by 163 publications

References 36 publications

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

Investigation of the electro-spinnability of alginate solutions containing gold precursor HAuCl 4

A review on electrospun bio-based polymers for water treatment

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