Three-Dimensional DNA Crystals as Molecular Sieves

Paukstelis, Paul J.

doi:10.1021/ja061322r

Cited by 58 publications

(49 citation statements)

References 22 publications

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“…[6] The structural roles of DNA in setting up nanoscale assemblies [7] and lattices are being discussed. [8,9] This confirms that rulebased DNA duplex formation occurs in non-natural chemical contexts. Less clear, though, is how embedding DNA duplexes in nanostructured environments affects thermodynamic stability, kinetics of hybridization, and cooperativity of formation.…”

supporting

confidence: 67%

Two Base Pair Duplexes Suffice to Build a Novel Material

et al. 2009

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supporting

confidence: 67%

Two Base Pair Duplexes Suffice to Build a Novel Material

et al. 2009

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“…Once interpreted, this structure has been reproduced in longer strands, leading to less dense hexagonal packing. This has been done by mixing two sequences (N ¼ 24 and N ¼ 11) that effectively add one full helical turn between the inter-helical contact points [81] (Fig. 20b).…”

Section: Three-dimensional Crystalsmentioning

confidence: 99%

DNA-Based Soft Phases

Bellini¹,

Cerbino²,

Zanchetta³

2011

Topics in Current Chemistry

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This chapter reviews the state-of-the-art in the study of molecular or colloidal systems whose mutual interactions are mediated by DNA molecules. In the last decade, the robust current knowledge of DNA interactions has enabled an impressive growth of self-assembled DNA-based structures that depend crucially on the properties of DNA-DNA interactions. In many cases, structures are built on design by exploiting the programmable selectivity of DNA interactions and the modularity of their strength. The study of DNA-based materials is definitely an emerging field in condensed matter physics, nanotechnology, and material science. This chapter will consider both systems that are entirely constructed by DNA and hybrid systems in which latex or metal colloidal particles are coated by DNA strands. We will confine our discussion to systems in which DNA-mediated interactions promote the formation of "phases," that is structures extending on length scales much larger than the building blocks. Their self-assembly typically involves a large number of interacting particles and often features hierarchical stages of structuring. Because of the possibility of fine-tuning the geometry and strength of the DNA-mediated interactions, these systems are characterized by a wide variety of patterns of self-assembly, ranging from amorphous, to liquid crystalline, to crystalline in one, two, or three dimensions.

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“…The first example of integrating proteins, albeit non-specifically, within a 3D DNA crystal was the demonstration that the expanded non-canonical lattice could function as a macromolecule sieve [14]. The 9 nm diameter solvent channels running down the six-fold symmetry axis of these crystals were capable of absorbing proteins up to~45 kDa, with the amount of absorbed protein inversely proportional to its molecular weight.…”

Section: Dna Crystal Applicationsmentioning

confidence: 99%

3D DNA Crystals and Nanotechnology

Paukstelis

Seeman

2016

Crystals

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DNA's molecular recognition properties have made it one of the most widely used biomacromolecular construction materials. The programmed assembly of DNA oligonucleotides has been used to create complex 2D and 3D self-assembled architectures and to guide the assembly of other molecules. The origins of DNA nanotechnology are rooted in the goal of assembling DNA molecules into designed periodic arrays, i.e., crystals. Here, we highlight several DNA crystal structures, the progress made in designing DNA crystals, and look at the current prospects and future directions of DNA crystals in nanotechnology.

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Three-Dimensional DNA Crystals as Molecular Sieves

Cited by 58 publications

References 22 publications

Two Base Pair Duplexes Suffice to Build a Novel Material

Two Base Pair Duplexes Suffice to Build a Novel Material

DNA-Based Soft Phases

3D DNA Crystals and Nanotechnology

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