Three-dimensional distribution of CT attenuation in the lumbar spine pedicle wall

Irie, Tomoyo Y.; Orías, Alejandro A. Espinoza; Segami, Kazuyuki; Iwasaki, Norimasa; An, Howard S.; Inoue, Nozomu

doi:10.1038/s41598-020-80676-5

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Each point of the endplate point-cloud model was moved in a direction opposite to the normal vector. At each point-cloud point, the corresponding HU value was calculated by trilinear interpolation of HU values at 8 adjacent volumes in 2 axial CT slices adjacent to each point ( Fig 1B ) [ 36 , 37 ]. A mean value of the HUs of the all points in the endplate point-cloud model was calculated at each depth ( Fig 2 ).…”

Section: Methodsmentioning

confidence: 99%

Regional distribution of computed tomography attenuation across the lumbar endplate

et al. 2021

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The vertebral endplate forms a structural boundary between intervertebral disc and the trabecular bone of the vertebral body. As a mechanical interface between the stiff bone and resilient disc, the endplate is the weakest portion of the vertebral-disc complex and is predisposed to mechanical failure. However, the literature concerning the bone mineral density (BMD) distribution within the spinal endplate is comparatively sparse. The objective of this study is to investigate the three-dimensional (3D) distribution of computed tomography (CT) attenuation across the lumbosacral endplate measured in Hounsfield Units (HU). A total of 308 endplates from 28 cadaveric fresh-frozen lumbosacral spines were used in this study. Each spine was CT-scanned and the resulting DICOM data was used to obtain HU values of the bone endplate. Each individual endplate surface was subdivided into five clinically-relevant topographic zones. Attenuation was analyzed by spinal levels, sites (superior or inferior endplate) and endplate region. The highest HU values were found at the S1 endplate. Comparisons between the superior and inferior endplates showed the HU values in inferior endplates were significantly higher than those in the superior endplates within the same vertebra and the HU values in endplates cranial to the disc were significantly higher than those in the endplates caudal to the disc within the same disc. Attenuation in the peripheral region was significantly higher than in the central region by 32.5%. Regional comparison within the peripheral region showed the HU values in the posterior region were significantly higher than those in the anterior region and the HU values in the left region were significantly higher than those in the right region. This study provided detailed data on the regional HU distribution across the lumbosacral endplate, which can be useful to understand causes of some endplate lesions, such as fracture, and also to design interbody instrumentation.

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Section: Methodsmentioning

confidence: 99%

Regional distribution of computed tomography attenuation across the lumbar endplate

et al. 2021

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A phantom to simulate organ motion and its effect on dose distribution in carbon ion therapy for pancreatic cancer

Stengl,

Panow,

Arbes

et al. 2023

Phys. Med. Biol.

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Objective: Carbon ion radiotherapy is a promising radiation technique for malignancies like pancreatic cancer. However, organs’ motion imposes challenges for achieving homogeneous dose delivery. In this study, an anthropomorphic Pancreas Phantom for Ion-beam Therapy (PPIeT) was developed to simulate breathing and gastrointestinal motion during radiotherapy.Approach: The developed phantom contains a pancreas, two kidneys, a duodenum, a spine and a spinal cord. The shell of the organs was 3D printed and filled with agarose-based mixtures. Hounsfield Units (HU) of PPIeTs’ organs were measured by CT. The pancreas motion amplitude in cranial-caudal (CC) direction was evaluated from patients’ 4D CT data. Motions within the obtained range were simulated and analyzed in PPIeT using MRI. Additionally, GI motion was mimicked by changing the volume of the duodenum and quantified by MRI. A patient-like treatment plan was calculated for carbon ions, and the phantom was irradiated in a static and moving condition. Dose measurements in the organs were performed using an ionization chamber and dosimetric films.Main results: PPIeT presented tissue equivalent HU and reproducible breathing-induced CC displacements of the pancreas between (3.98±0.36) mm and a maximum of (18.19±0.44) mm. The observed maximum change in distance of (14.28±0.12) mm between pancreas and duodenum was consistent with findings in patients. Carbon ion irradiation revealed homogenous coverage of the virtual tumor at the pancreas in static condition with a 1 % deviation from the treatment plan. Instead, the dose delivery during motion with the maximum amplitude yielded an underdosage of 21 % at the target and an increased uncertainty by two orders of magnitude. Significance: A dedicated phantom was designed and developed for breathing motion assessment of dose deposition during carbon ion radiotherapy. PPIeT is a unique tool for dose verification in the pancreas and its organs at risk during end-to-end tests.

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Three-dimensional distribution of CT attenuation in the lumbar spine pedicle wall

Cited by 2 publications

References 37 publications

Regional distribution of computed tomography attenuation across the lumbar endplate

Regional distribution of computed tomography attenuation across the lumbar endplate

A phantom to simulate organ motion and its effect on dose distribution in carbon ion therapy for pancreatic cancer

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