“…Cancerous and non-cancerous cellular constituents of the TME, including the microbiome, communicate with one another by secreting soluble factors and/or releasing EVs (75,103,(105)(106)(107)(108)(109)(110). Therefore, EVs are an integral and functional non-cellular component of the TME (75,103,111,112). Briefly, EVs are membrane-enclosed particles subdivided into exosomes, microvesicles and oncosomes depending on their size, biogenesis, function, etc.…”