Three-Dimensional BioAssembly Tool for Generating Viable Tissue-Engineered Constructs

Smith, Cynthia M.; Stone, Alice L.; Parkhill, Robert L.; Stewart, Robert L.; Simpkins, Mark W.; Kachurin, Anatoly M.; Warren, W. L.; Williams, Stuart K.

doi:10.1089/1076327042500274

Cited by 99 publications

(119 citation statements)

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“…Different cell types can be embedded at predefined locations inside the printed polymers [12], allowing the creation of artificial tissues and organs [30,45,49]. The increased control over the scaffold structure also allows strands to be printed closer together, contributing to the mitigation of nutrient limitation.…”

Section: Introductionmentioning

confidence: 99%

Design criteria for a printed tissue engineering construct: A mathematical homogenization approach

Shipley¹,

Jones²,

Dyson

et al. 2009

Journal of Theoretical Biology

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Cartilage tissue repair procedures currently under development aim to create a construct in which patient-derived cells are seeded and expanded ex vivo before implantation back into the body. The key challenge is producing physiologically realistic constructs that mimic real tissue structure and function. One option with vast potential is to print strands of material in a 3D structure called a scaffold that imitates the real tissue structure; the strands are composed of gel seeded with cells and so provide a template for cartilaginous tissue growth. The scaffold is placed in the construct and pumped with nutrient-rich culture medium to supply nutrients to the cells and remove waste products, thus promoting tissue growth.In this paper we use asymptotic homogenization to determine the effective flow and transport properties of such a printed scaffold system. These properties are used to predict the distribution of nutrient/waste products through the construct, and to specify design criteria for the scaffold that will optimise the growth of functional tissue. Keywords

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Section: Introductionmentioning

confidence: 99%

Design criteria for a printed tissue engineering construct: A mathematical homogenization approach

Shipley¹,

Jones²,

Dyson

et al. 2009

Journal of Theoretical Biology

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“…Printing patterns can be generated, modified and printed using computer-aided software such as CAD (Computer Aided Design). The turnaround time taken for making modifications in the CAD files is just seconds to minutes making this process easy and user-friendly [18] . This is advantageous to bioprint custom made structures such as tissues and organs for transplantation.…”

Section: Methods For Bioprinting Tissue/organsmentioning

confidence: 99%

“…The deposition area is illuminated with a light source that enables the activation of photoinitiators. A video camera is attached to the xyz stage to monitor and control the printing process [18,33,34] . Microextrusion technique has been successfully used to print scaffolds for tissue engineering [34] .…”

Section: Microextrusionmentioning

confidence: 99%

3D bioprinting technology for regenerative medicine applications

Sundaramurthi¹,

Rauf²,

Hauser³

2016

IJB

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Alternative strategies that overcome existing organ transplantation methods are of increasing importance because of ongoing demands and lack of adequate organ donors. Recent improvements in tissue engineering techniques offer improved solutions to this problem and will influence engineering and medicinal applications. Tissue engineering employs the synergy of cells, growth factors and scaffolds besides others with the aim to mimic the native extracellular matrix for tissue regeneration. Three-dimensional (3D) bioprinting has been explored to create organs for transplantation, medical implants, prosthetics, in vitro models and 3D tissue models for drug testing. In addition, it is emerging as a powerful technology to provide patients with severe disease conditions with personalized treatments. Challenges in tissue engineering include the development of 3D scaffolds that closely resemble native tissues. In this review, existing printing methods such as extrusion-based, robotic dispensing, cellular inkjet, laser-assisted printing and integrated tissue organ printing (ITOP) are examined. Also, natural and synthetic polymers and their blends as well as peptides that are exploited as bioinks are discussed with emphasis on regenerative medicine applications. Furthermore, applications of 3D bioprinting in regenerative medicine, evolving strategies and future perspectives are summarized.

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“…Future studies are recommended to tackle challenges associated with 3D bioprinting in the realm of ACTE. One important issue is improving the design of the "bio-ink," as current bio-inks have major limitations such as a loss of their mechanical properties during in vitro culturing [122], or untenable variations between different batches of bio-ink [123]. Studies to investigate the response of 3D-printed constructs to mechanical stimuli would also be of great interest.…”

Section: Future Directionsmentioning

confidence: 99%

A flow perfusion bioreactor with controlled mechanical stimulation: Application in cartilage tissue engineering and beyond

Nazempour¹,

Wie²

2018

J Stem Cell Ther Transplant

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Three-Dimensional BioAssembly Tool for Generating Viable Tissue-Engineered Constructs

Cited by 99 publications

References 0 publications

Design criteria for a printed tissue engineering construct: A mathematical homogenization approach

Design criteria for a printed tissue engineering construct: A mathematical homogenization approach

3D bioprinting technology for regenerative medicine applications

A flow perfusion bioreactor with controlled mechanical stimulation: Application in cartilage tissue engineering and beyond

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