Three‐dimensional analysis of molar development in the mouse from the cap to bell stage

Lesot, Hervé; Hovořáková, Mária; Peterka, Miroslav; Peterková, Renata

doi:10.1111/adj.12132

Cited by 27 publications

(24 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the developmental mechanisms underlying tooth organogenesis are evolutionarily conserved across mammals (19,(22)(23)(24), given the highly derived dentitions of mice (which lack premolars, canines, and replacement teeth) and the vastly different life histories, the finer details of dental patterning are not the same (19). Previous quantitative genetic analyses indicate that the IC model may not work as well for primates as it does for mice because the former's phenotype can comingle the effect of a genetic patterning mechanism(s) with systemically modulated somatic factors.…”

mentioning

confidence: 99%

The integration of quantitative genetics, paleontology, and neontology reveals genetic underpinnings of primate dental evolution

Hlusko

Schmitt

Monson

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

107

View full text Add to dashboard Cite

Developmental genetics research on mice provides a relatively sound understanding of the genes necessary and sufficient to make mammalian teeth. However, mouse dentitions are highly derived compared with human dentitions, complicating the application of these insights to human biology. We used quantitative genetic analyses of data from living nonhuman primates and extensive osteological and paleontological collections to refine our assessment of dental phenotypes so that they better represent how the underlying genetic mechanisms actually influence anatomical variation. We identify ratios that better characterize the output of two dental genetic patterning mechanisms for primate dentitions. These two newly defined phenotypes are heritable with no measurable pleiotropic effects. When we consider how these two phenotypes vary across neontological and paleontological datasets, we find that the major Middle Miocene taxonomic shift in primate diversity is characterized by a shift in these two genetic outputs. Our results build on the mouse model by combining quantitative genetics and paleontology, and thereby elucidate how genetic mechanisms likely underlie major events in primate evolution.paleontology | quantitative genetics | primates | neontology | dental variation T he relationship between genotype and phenotype is critical to evolutionary biology, because it influences how phenotypes respond to selective pressures and evolve (1, 2). Paleontologists have long sought to incorporate the etiology of the dental phenotype to inform on questions of environmental, dietary, and adaptive change over time (3)(4)(5)(6). This research has been advanced significantly by the revolution in developmental genetics over the past few decades (7). Experimental research on mice has yielded tremendous biological insight (8). However, for human phenotypes, ranging from inflammation (9) to placentation (10), the limitations of the mouse model due to the ∼140 million years ago of evolution that have occurred since our last common ancestor ∼70 Ma (11) are starting to be recognized. Here, we demonstrate how to overcome the limitations of the mouse model's application to the primate dentition by integrating research from quantitative genetics, neontology, and paleontology. The insights gained from this transdisciplinary approach have implications for all of these seemingly disparate subdisciplines of biology.

show abstract

mentioning

confidence: 99%

The integration of quantitative genetics, paleontology, and neontology reveals genetic underpinnings of primate dental evolution

Hlusko

Schmitt

Monson

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

107

View full text Add to dashboard Cite

show abstract

“…This peculiar distribution of junctional complexes has been proposed to be implicated in the sliding of rows between each other, which is furthered by the observation that this organization is modified when ameloblasts start secreting radial enamel, especially for microfilaments (Kallenbach, , ; Nishikawa et al ., ; Yuan and Nishikawa, ; Nishikawa, ). Cells of the Stratum Intermedium , the tissue lying against the basal pole of ameloblasts, could also have a role in the coordination of ameloblast function and migration (Lesot et al, ).…”

Section: Resultsmentioning

confidence: 99%

Relationships Between Enamel Prism Decussation and Organization of the Ameloblast Layer in Rodent Incisors

Alloing-Séguier

Marivaux

Barczi

et al. 2018

The Anatomical Record

View full text Add to dashboard Cite

Rodent enamel microstructure has been extensively investigated, primarily on the basis of 2D electronic microscopy data. The nature and dynamics of the ameloblasts (the enamel‐secreting cells) have also been well studied. However, critical issues still remain surrounding exactly how the ameloblasts produce the astonishing microstructural complexity of enamel, and how this subtle architecture evolved through time. In this article, we used a new methodology based on confocal laser microscopy to reconstruct the enamel microstructure of rodent incisors in three dimensions (3D) with the ameloblasts in situ. We proposed interpretations regarding the possible relationships between the workings of the ameloblasts and the resulting enamel prisms, especially how the phenomenon of decussation is generated. Finally, we were able to represent the two main types of modern rodent incisor microstructures (uniserial and multiserial decussations), as a set of parameters that have been entered into the 3D enamel simulation software Simulenam to generate 3D models that can be digitally manipulated. Associating 2D data of incisor enamel microstructure of fossil rodents and Simulenam, it was then possible to better understand how the various decussation parameters evolved through time and gave rise to the two modern microstructure types from the same ancestral type (pauciserial). This study also confirmed that rodent and artiodactyl enamel do not share the same mechanism of decussation formation. Anat Rec, 302:1195–1209, 2019. © 2018 Wiley Periodicals, Inc.

show abstract

“…Estas etapas se desarrollan a través de cinco fenómenos: el crecimiento del germen del diente, el desarrollo del asa cervical, la histogénesis del órgano del esmalte, el plegamiento de la unión epitelio-mesenquimal asociada con la formación de las cúspides, y el cambio de la heterogeneidad celular en el mesénquima [29]. Sin embargo, al contrastar dichos reportes con los resultados de este estudio, es posible determinar que los Gaete et al (7) describieron el desarrollo del primer molar mandibular en ratones Mus musculus de la cepa ICR/JCL, encontrando que la proliferación de la lámina dental comenzó en el día E12.5, el estadio yema entre los días E13.5 y E14.5, el estadio casquete entre los días E14.5 y E16.5 y el estadio campana temprana en el día E17.5.…”

Section: Discussionunclassified

Desarrollo embrionario del primer molar mandibular del ratón Mus musculus cepa albino suizo

Díaz

Sánchez

Mejía

2015

View full text Add to dashboard Cite

Aim:Mus musculus of the Swiss albino strain. Materials and methods:Observational descriptive study of the embryonic development of the the Vivarium of School of Health at Universidad del Valle, aged between eighth and tenth week. optical light microscope. Results:The process of dental morphogenesis was described from different embryonic stages Conclusion: According to reports from the previous literature on embryonic developmentMus musculus Swiss albino strain at the Vivarium of the School of Health at Universidad del Valle, tooth morphogenesis occurs earlier in parallel to stages of embrionic development. Keywords: Mouse Mus musculus, developmental biology, Theiler stages, dental morphogenesis, Desarrollo embrionario del primer molar mandibular del ratónMus musculus cepa albino suizo Resumen Objetivo: Describir el desarrollo embrionario del primer molar mandibular del ratón Mus musculus de la cepa albino suizo. Materiales y métodos:Estudio observacional de tipo descriptivo sobre el desarrollo embrionario del primer molar mandibular de 22 embriones de ratón Mus musculus cepa albino suizo obtenidos del Bioterio de la Facultad de Salud de la Universidad del Valle, con edades comprendidas entre E10.5 para ser analizadas a través de un microscopio óptico de luz.

show abstract

Three‐dimensional analysis of molar development in the mouse from the cap to bell stage

Cited by 27 publications

References 111 publications

The integration of quantitative genetics, paleontology, and neontology reveals genetic underpinnings of primate dental evolution

The integration of quantitative genetics, paleontology, and neontology reveals genetic underpinnings of primate dental evolution

Relationships Between Enamel Prism Decussation and Organization of the Ameloblast Layer in Rodent Incisors

Desarrollo embrionario del primer molar mandibular del ratón Mus musculus cepa albino suizo

Contact Info

Product

Resources

About