“…In vitro studies have shown that cyclic strain influences the angiogenic responses of endothelial cells, including the effects on vascular network formation, cell apoptosis, migration and proliferation, and various growth factors, enzymes, genes, and proteins related to angiogenesis (19,21,28,36,38,57,58,63,64). In addition, the angiogenic responses of cells subjected to strain depend on the substrate used to culture the cells (19,38,57,58,64). A summary of the results from these studies is organized by substrate type in Table 1 and includes the cell types, strain parameters, and angiogenic responses.…”