Three different anti-lipopolysaccharide factors identified from giant freshwater prawn, Macrobrachium rosenbergii

Ren, Qian; Zhao, Zhen; Li, Xin-chang; Jie-Du,; Hui, Kai-Min; Zhang, Chi-Yu; Wang, Wen

doi:10.1016/j.fsi.2012.06.032

Cited by 34 publications

(18 citation statements)

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“…The distribution of nLvALF2 suggested that it might be a fundamental component of the immunological barrier. After WSSV infection, the ALF of Pacifastacus leniusculus , and MrALF5 , MrALF6 , and MrALF7 of Macrobrachium rosenbergii , were up-regulated (Liu et al, 2006;Ren et al, 2012). The transcriptional level of nLvALF2 increased signifi cantly at 6 hpi ( P <0.01) and maintained this status until 72 hpi ( P <0.01), thus exhibiting a positive and long-lasting protection.…”

Section: Discussionmentioning

confidence: 97%

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A new ALF from Litopenaeus vannamei and its SNPs related to WSSV resistance

et al. 2014

Chin. J. Ocean. Limnol.

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Anti-lipopolysaccharide factors (ALFs) are basic components of the crustacean immune system that defend against a range of pathogens. The cDNA sequence of a new ALF, designated nLvALF2 , with an open reading frame encoding 132 amino acids was cloned. Its deduced amino acid sequence contained the conserved functional domain of ALFs, the LPS binding domain (LBD). Its genomic sequence consisted of three exons and four introns. nLvALF2 was mainly expressed in the Oka organ and gills of shrimps. The transcriptional level of nLvALF2 increased signifi cantly after white spot syndrome virus (WSSV) infection, suggesting its important roles in protecting shrimps from WSSV. Single nucleotide polymorphisms (SNPs) were found in the genomic sequence of nLvALF2 , of which 38 were analyzed for associations with the susceptibility/resistance of shrimps to WSSV. The loci g.2422 A>G, g.2466 T>C, and g.2529 G>A were signifi cantly associated with the resistance to WSSV ( P <0.05). These SNP loci could be developed as markers for selection of WSSV-resistant varieties of Litopenaeus vannamei .

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Section: Discussionmentioning

confidence: 97%

“…vannamei , Fenneropenaeus chinensis ( F . chinensis ), and other crustaceans (Gross et al, 2001;Supungul et al, 2004;Jimenez-Vega and Vargas-Albores, 2007;Ren et al, 2012;. ALF exhibits strong broad-spectrum antibacterial activity (Somboonwiwat et al, 2005;Beale et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A new ALF from Litopenaeus vannamei and its SNPs related to WSSV resistance

et al. 2014

Chin. J. Ocean. Limnol.

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“…Ren et al . () reported three anti‐LPS factor proteins i.e., Mr ALF 5, 6 and 7 from M. rosenbergii . Mr ALF5 was expressed in hepatopancreas and gills, Mr ALF 6 was highly expressed in intestine and hepatopancreas and Mr ALF7 was strictly confined to hepatopancreas only.…”

Section: Immune Systemmentioning

confidence: 99%

Impacts of environmental and biological stressors on immune system ofMacrobrachium rosenbergii

Kumaresan

Palanisamy

Pasupuleti

et al. 2016

Reviews in Aquaculture

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Macrobrachium rosenbergii commonly called giant freshwater prawn is a widely farmed crustacean in freshwater. Similar to other aquatic organisms, their growth and well-being is influenced by various physical, chemical and biological factors. We discuss about the critical growth limiting factors as well as disease causing agents and the potential immune molecules of M. rosenbergii that are proved to involve in preventing and/or responding to those limiting factors.

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“…LpALF. However, the evolutionary analysis of the ALF genes in crus-942 taceans showed no evidence of positive selection but rather is 943 likely to be by purifying selection (Ren et al, 2012a,b) (Ren et al, 2012b). Like other AMPs, such as penaeidin in penaeid 947 shrimps (Padhi et al, 2007), crustin in decapods (Padhi et al, …”

mentioning

confidence: 99%