Sequence diversity and evolution of antimicrobial peptides in invertebrates

Tassanakajon, Anchalee; Somboonwiwat, Kunlaya; Amparyup, Piti

doi:10.1016/j.dci.2014.05.020

Cited by 145 publications

(119 citation statements)

References 174 publications

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“…For instance, in P. monodon, a Type IIa crustin is essentially active against Gram-positive bacteria, while Type IIb crustins are active against both Gram-positive and Gramnegative bacteria [69,70]. Interestingly, Type III and IV crustins show antimicrobial and/or antiprotease activity [67], whereas Type III crustins lacking the N-terminal proline/argininedomain and Type IV crustins from shrimp [71,72] only have antiprotease activity [67]. Type IV crustins from crabs exhibit both antimicrobial and antiprotease activities [72,73].…”

Section: (Iii) Crustinsmentioning

confidence: 99%

“…Crustins are antimicrobial polypeptides (6-22 kDa; pI 4-8) containing a whey acidic protein (WAP) domain [67]. This WAP domain, which is also found in some mammalian proteins, supports different biological functions, including antiprotease activities [68].…”

Section: (Iii) Crustinsmentioning

confidence: 99%

“…Crustins are widely distributed across crustaceans but some sequences have also been discovered in insect genomes [42]. Crustins from crustaceans are composed of four members (Types I-IV), which differ by their N-terminal sequence [67]. While the sequence of Type I crustins begins with a cysteine-rich domain, Type II crustins (subtypes IIa and IIb) harbour a glycine-rich hydrophobic domain at the N-terminal position ahead of the cysteine-rich rstb.royalsocietypublishing.org Phil.…”

Section: (Iii) Crustinsmentioning

confidence: 99%

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Antimicrobial peptides in marine invertebrate health and disease

Destoumieux-Garzón

Rosa

Schmitt

et al. 2016

Phil. Trans. R. Soc. B

116

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One contribution of 13 to a theme issue 'Evolutionary ecology of arthropod antimicrobial peptides'. Aquaculture contributes more than one-third of the animal protein from marine sources worldwide. A significant proportion of aquaculture products are derived from marine protostomes that are commonly referred to as 'marine invertebrates'. Among them, penaeid shrimp (Ecdysozosoa, Arthropoda) and bivalve molluscs (Lophotrochozoa, Mollusca) are economically important. Mass rearing of arthropods and molluscs causes problems with pathogens in aquatic ecosystems that are exploited by humans. Remarkably, species of corals (Cnidaria) living in non-exploited ecosystems also suffer from devastating infectious diseases that display intriguing similarities with those affecting farmed animals. Infectious diseases affecting wild and farmed animals that are present in marine environments are predicted to increase in the future. This paper summarizes the role of the main pathogens and their interaction with host immunity, with a specific focus on antimicrobial peptides (AMPs) and pathogen resistance against AMPs. We provide a detailed review of penaeid shrimp AMPs and their role at the interface between the host and its resident/pathogenic microbiota. We also briefly describe the relevance of marine invertebrate AMPs in an applied context. This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.

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Section: (Iii) Crustinsmentioning

confidence: 99%

Section: (Iii) Crustinsmentioning

confidence: 99%

Section: (Iii) Crustinsmentioning

confidence: 99%

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Antimicrobial peptides in marine invertebrate health and disease

Destoumieux-Garzón

Rosa

Schmitt

et al. 2016

Phil. Trans. R. Soc. B

116

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“…Moreover, AMPs have other functions such as fostering the right conditions for mutualists and acting as modulators of the immune response [9][10][11]. A large number of studies and reviews on AMPs have been published to date, but the majority of studies on arthropod AMPs have focused on their biochemical and molecular properties [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Perspectives on the evolutionary ecology of arthropod antimicrobial peptides

Rolff

Schmid‐Hempel

2016

Phil. Trans. R. Soc. B

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One contribution of 13 to a theme issue 'Evolutionary ecology of arthropod antimicrobial peptides'. Antimicrobial peptides (AMPs) are important elements of the innate immune defence in multicellular organisms that target and kill microbes. Here, we reflect on the various points that are raised by the authors of the 11 contributions to a special issue of Philosophical Transactions on the 'evolutionary ecology of arthropod antimicrobial peptides'. We see five interesting topics emerging. (i) AMP genes in insects, and perhaps in arthropods more generally, evolve much slower than most other immune genes. One explanation refers to the constraints set by AMPs being part of a finely tuned defence system. A new view argues that AMPs are under strong stabilizing selection. Regardless, this striking observation still invites many more questions than have been answered so far. (ii) AMPs almost always are expressed in combinations and sometimes show expression patterns that are dependent on the infectious agent. While it is often assumed that this can be explained by synergistic interactions, such interactions have rarely been demonstrated and need to be studied further. Moreover, how to define synergy in the first place remains difficult and needs to be addressed. (iii) AMPs play a very important role in mediating the interaction between a host and its mutualistic or commensal microbes. This has only been studied in a very small number of (insect) species. It has become clear that the very same AMPs play different roles in different situations and hence are under concurrent selection. (iv) Different environments shape the physiology of organisms; especially the host-associated microbial communities should impact on the evolution host AMPs. Studies in social insects and some organisms from extreme environments seem to support this notion, but, overall, the evidence for adaptation of AMPs to a given environment is scant. (v) AMPs are considered or already developed as new drugs in medicine. However, bacteria can evolve resistance to AMPs. Therefore, in the light of our limited understanding of AMP evolution in the natural context, and also the very limited understanding of the evolution of resistance against AMPs in bacteria in particular, caution is recommended. What is clear though is that study of the ecology and evolution of AMPs in natural systems could inform many of these outstanding questions, including those related to medical applications and pathogen control.This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.

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“…Zhang and Zhu (2012) also classified four types of crustins, including insect crustins containing an extra aromatic amino acidrich region between the cysteine-rich domain and WAP domain. Tassanakajon et al [37] classified all crustins into five groups, namely, type I, type II, type III, type IV, and type V. Type I crustins contain a signal peptide and cysteine-rich region at the N-terminus, and WAP domain at the C-terminus. Type II crustins have an extra glycine-rich domain between the signal peptide and cysteine-rich domain.…”

Section: Discussionmentioning

confidence: 99%