Three Decades of Research about the Corona Around Nanoparticles: Lessons Learned and Where to Go Now

Lundqvist, Martin; Cedervall, Tommy

doi:10.1002/smll.202000892

Cited by 36 publications

(43 citation statements)

References 51 publications

(90 reference statements)

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“…Recent advancements in intra-articular drug delivery have leveraged both small sizes and electrostatic interactions with the anionic ECM 2,3. . It is well known that micro-and nanoscale drug delivery approaches are immediately subjected to the high abundance of host-derived biological components such as proteins, carbohydrates, and lipids 4 . These bioactive components can alter the size and surface composition of the particles and equip them with a distinct biological identity, in turn, dictating their physiological and therapeutic outcomes 4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…It is well known that micro-and nanoscale drug delivery approaches are immediately subjected to the high abundance of host-derived biological components such as proteins, carbohydrates, and lipids 4 . These bioactive components can alter the size and surface composition of the particles and equip them with a distinct biological identity, in turn, dictating their physiological and therapeutic outcomes 4,5 . For instance, studies on systemic administration have shown that just a simple change from blood plasma to serum had a profound difference in both protein corona composition and nanoparticle (NP) fate, demonstrating the importance of selecting the appropriate environment to account for in vivo settings 6 .…”

Section: Introductionmentioning

confidence: 99%

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Synovial Fluid Profile Dictates Nanopracticle Uptake into Cartilage- Implications of the Protein Corona for Novel Arthitis Treatments

Mentzer

Selldén

Råberg

et al. 2022

Preprint

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A major obstacle for joint drug delivery is to penetrate the dense, negatively charged cartilage matrix. Previous studies have extensively investigated particle approaches to increase uptake efficiency into tissues but have neglected to address potential interactions with the synovial fluid. Here, we developed a nanoparticle (NP) panel with varying PEGylation and incubated them with synovial fluid from either osteoarthritic (OA) or rheumatoid arthritis (RA) patients, or fetal calf serum (FCS). Compared to nonprotein- covered NPs, the formed protein coronas majorly impacted NP uptake into cartilage tissue and dictated their uptake in chondrocytes and monocytes - a measure of targeting efficiency and clearance potential. Utilizing a quantitative proteomics approach, we identified certain families of proteins on all panel members irrespective of the NP modifications. Nonetheless, NP-, and protein-specific differences were also observed between the groups, and candidate proteins were identified that could account for the observed differences. This study is the first to demonstrate how protein coronas from different biological origins impact NP uptake into cartilage, emphasizing the importance of considering the several aspects of the biological microenvironment for successful translation of drug delivery vehicles into clinics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synovial Fluid Profile Dictates Nanopracticle Uptake into Cartilage- Implications of the Protein Corona for Novel Arthitis Treatments

Mentzer

Selldén

Råberg

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Another crucial aspect is experimental obstacles affecting the characterization of NPs and their corona profiles. Using diluted NPs to study biomolecular/protein corona is one practical approach that can minimize such impurity issues 110 , 111 .…”

Section: Introductionmentioning

confidence: 99%

Sex as an important factor in nanomedicine

et al. 2021

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Nanomedicine has demonstrated substantial potential to improve the quality and efficacy of healthcare systems. Although the promise of nanomedicine to transform conventional medicine is evident, significant numbers of therapeutic nanomedicine products have failed in clinical trials. Most studies in nanomedicine have overlooked several important factors, including the significance of sex differences at various physiological levels. This report attempts to highlight the importance of sex in nanomedicine at cellular and molecular level. A more thorough consideration of sex physiology, among other critical variations (e.g., health status of individuals), would enable researchers to design and develop safer and more-efficient sex-specific diagnostic and therapeutic nanomedicine products.

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“…Yet so far, no studies have addressed the potential effect of the synovial fluid composition on such drug delivery vehicles, which is vital to understand and predict pharmacokinetic profiles and behaviors. For systemic administration, it is well known that micro and nanoscale drug delivery approaches are immediately subjected to the high abundance of host-derived biological components such as proteins, carbohydrates, and lipids 5 . These bioactive components can alter the size and surface composition of the particles and equip them with a distinct biological identity, in turn, dictating their physiological and therapeutic outcomes .…”

Section: Introductionmentioning

confidence: 99%

Synovial Fluid Profile Dictates Nanopracticle Uptake into Cartilage- Implications of the Protein Corona for Novel Arthitis Treatments

Mentzer

Selldén

Råberg

et al. 2021

Preprint

View full text Add to dashboard Cite

A major obstacle for joint drug delivery is to penetrate the dense, negatively charged cartilage matrix. Previous studies have extensively investigated particle approaches to cartilage tissue uptake but have neglected to address potential interactions between the particles and the synovial fluid. Here, a NP panel with different PEGylation were incubated with synovial fluid from either rheumatoid or osteoarthritic patients, or FCS. Compared to non-protein covered NPs, we observed a prominent impact of the protein coronas on NP uptake into cartilage, chondrocytes, and monocytes. Utilizing a quantitative proteomics approach, we identified abundant proteins on all panel members irrespective of the NP modifications. Nonetheless, NP and protein condition-specific differences were also observed between the groups. Our study, therefore, suggests that the protein abundance dictates NP efficacy, emphasizing the importance of considering the biological milieu for translating drug delivery designs to the clinic.

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Three Decades of Research about the Corona Around Nanoparticles: Lessons Learned and Where to Go Now

Abstract: This will be a more challenging task than just detect them in the corona.

Cited by 36 publications

References 51 publications

Synovial Fluid Profile Dictates Nanopracticle Uptake into Cartilage- Implications of the Protein Corona for Novel Arthitis Treatments

Synovial Fluid Profile Dictates Nanopracticle Uptake into Cartilage- Implications of the Protein Corona for Novel Arthitis Treatments

Sex as an important factor in nanomedicine

Synovial Fluid Profile Dictates Nanopracticle Uptake into Cartilage- Implications of the Protein Corona for Novel Arthitis Treatments

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