Sex as an important factor in nanomedicine

Hajipour, Mohammad Javad; Aghaverdi, Haniyeh; Serpooshan, Vahid; Vali, Hojatollah; Sheibani, Sara; Mahmoudi, Morteza

doi:10.1038/s41467-021-23230-9

Cited by 53 publications

(41 citation statements)

References 131 publications

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“…Elevated level of monocytes is usually due to infections, blood disorders, or an increased immunogenic response. It is known that rodents have different innate/adaptive immune responses depending on their gender [ 35 ]. Female mice and rats demonstrate stronger phagocytic activity of macrophages than males.…”

Section: Discussionmentioning

confidence: 99%

“…Such a difference in the response of two animals’ sexes to external impact is quite understandable. Back in the 1990s the biomedical research community demonstrated the importance of sex as a biological variable in laboratory and clinical experiments [ 35 ]. This fact emphasizes the importance of this study carried out on both sexes of two animal species.…”

Section: Discussionmentioning

confidence: 99%

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Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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“…This is important because recent reports revealed the critical role of sex in safety and therapeutic efficacy of nanoparticles. [ 206 ]…”

Section: In Vivo Antibacterial Impacts Of Npsmentioning

confidence: 99%

Nanotechnology for Targeted Detection and Removal of Bacteria: Opportunities and Challenges

et al. 2021

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The emergence of nanotechnology has created unprecedented hopes for addressing several unmet industrial and clinical issues, including the growing threat so-termed "antibiotic resistance" in medicine. Over the last decade, nanotechnologies have demonstrated promising applications in the identification, discrimination, and removal of a wide range of pathogens. Here, recent insights into the field of bacterial nanotechnology are examined that can substantially improve the fundamental understanding of nanoparticle and bacteria interactions. A wide range of developed nanotechnology-based approaches for bacterial detection and removal together with biofilm eradication are summarized. The challenging effects of nanotechnologies on beneficial bacteria in the human body and environment and the mechanisms of bacterial resistance to nanotherapeutics are also reviewed.

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“…Due to the gene mutation of KRAS in many cancer patients, the clinical performance is not satisfactory ( Kim et al, 2020 ). Another specific example is that sex also plays a critical role in the drug response, toxicity and other aspects ( Hajipour et al, 2021 ). Therefore, precision medicine has received more and more attention in recent years, which could significantly compensate for the shortcomings of conventional strategies ( Figure 2 ).…”

Section: Nanomaterials Therapeutics Overcome Drug Resistancementioning

confidence: 99%

Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

Cao¹,

Zhu²,

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Drug resistance is the most significant causes of cancer chemotherapy failure. Various mechanisms of drug resistance include tumor heterogeneity, tumor microenvironment, changes at cellular levels, genetic factors, and other mechanisms. In recent years, more attention has been paid to tumor resistance mechanisms and countermeasures. Nanomedicine is an emerging treatment platform, focusing on alternative drug delivery and improved therapeutic effectiveness while reducing side effects on normal tissues. Here, we reviewed the principal forms of drug resistance and the new possibilities that nanomaterials offer for overcoming these therapeutic barriers. Novel nanomaterials based on tumor types are an excellent modality to equalize drug resistance that enables gain more rational and flexible drug selectivity for individual patient treatment. With the emergence of advanced designs and alternative drug delivery strategies with different nanomaterials, overcome of multidrug resistance shows promising and opens new horizons for cancer therapy. This review discussed different mechanisms of drug resistance and recent advances in nanotechnology-based therapeutic strategies to improve the sensitivity and effectiveness of chemotherapeutic drugs, aiming to show the advantages of nanomaterials in overcoming of drug resistance for tumor chemotherapy, which could accelerate the development of personalized medicine.

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Sex as an important factor in nanomedicine

Cited by 53 publications

References 131 publications

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Nanotechnology for Targeted Detection and Removal of Bacteria: Opportunities and Challenges

Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

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