Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies

Rai, Muhammad Farooq; Collins, Kelsey H.; Lang, Annemarie; Maerz, Tristan; Geurts, Jeroen; Ruiz-Romero, Cristina; June, Ronald K.; Ramos, Yolande; Rice, Sarah J.; Ali, Shabana Amanda; Pastrello, Chiara; Jurisica, Igor; Thomas Appleton, C.; Rockel, Jason S.; Kapoor, Mohit

doi:10.1016/j.joca.2023.11.019

Cited by 9 publications

(1 citation statement)

References 122 publications

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“…Moreover, targeted MS techniques, such as selected reaction monitoring (SRM) and parallel reaction monitoring (PRM), enable precise quantification of specific proteins of interest, offering opportunities for biomarker validation and personalized medicine approaches in OP research [18][19][20]. MS-based proteomics also facilitates the characterization of post-translational modifications (PTMs) in bone proteins, providing insights into their functional roles and regulatory mechanisms in OP [21][22][23]. Overall, MS-based proteomics hold great promise for advancing our understanding of osteoporosis and identifying diagnostic markers and therapeutic targets for the disease.…”

Section: Mass Spectrometry-based Proteomicsmentioning

confidence: 99%

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Wang,

Xue,

et al. 2024

Biomolecules

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Osteoporosis (OP), a prevalent skeletal disorder characterized by compromised bone strength and increased susceptibility to fractures, poses a significant public health concern. This review aims to provide a comprehensive analysis of the current state of research in the field, focusing on the application of proteomic techniques to elucidate diagnostic markers and therapeutic targets for OP. The integration of cutting-edge proteomic technologies has enabled the identification and quantification of proteins associated with bone metabolism, leading to a deeper understanding of the molecular mechanisms underlying OP. In this review, we systematically examine recent advancements in proteomic studies related to OP, emphasizing the identification of potential biomarkers for OP diagnosis and the discovery of novel therapeutic targets. Additionally, we discuss the challenges and future directions in the field, highlighting the potential impact of proteomic research in transforming the landscape of OP diagnosis and treatment.

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Section: Mass Spectrometry-based Proteomicsmentioning

confidence: 99%

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Wang,

Xue,

et al. 2024

Biomolecules

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Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease

Roberts,

Rice

2024

Curr Rheumatol Rep

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Purpose of Review Osteoarthritis is a complex and highly polygenic disease. Over 100 reported osteoarthritis risk variants fall in non-coding regions of the genome, ostensibly conferring functional effects through the disruption of regulatory elements impacting target gene expression. In this review, we summarise the progress that has advanced our knowledge of gene enhancers both within the field of osteoarthritis and more broadly in complex diseases. Recent Findings Advances in technologies such as ATAC-seq have facilitated our understanding of chromatin states in specific cell types, bolstering the interpretation of GWAS and the identification of effector genes. Their application to osteoarthritis research has revealed enhancers as the principal regulatory element driving disease-associated changes in gene expression. However, tissue-specific effects in gene regulatory mechanisms can contribute added complexity to biological interpretation. Summary Understanding gene enhancers and their altered activity in specific cell and tissue types is the key to unlocking the genetic complexity of osteoarthritis. The use of single-cell technologies in osteoarthritis research is still in its infancy. However, such tools offer great promise in improving our functional interpretation of osteoarthritis GWAS and the identification of druggable targets. Large-scale collaborative efforts will be imperative to understand tissue and cell-type specific molecular mechanisms underlying enhancer function in disease.

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Non-apoptotic cell death in osteoarthritis: Recent advances and future

Ji,

Zhou,

Zhang

et al. 2024

Biomedicine & Pharmacotherapy

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Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies

Cited by 9 publications

References 122 publications

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease

Non-apoptotic cell death in osteoarthritis: Recent advances and future

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