Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease
Jack B. Roberts,
Sarah J. Rice
Abstract:Purpose of Review
Osteoarthritis is a complex and highly polygenic disease. Over 100 reported osteoarthritis risk variants fall in non-coding regions of the genome, ostensibly conferring functional effects through the disruption of regulatory elements impacting target gene expression. In this review, we summarise the progress that has advanced our knowledge of gene enhancers both within the field of osteoarthritis and more broadly in complex diseases.
Recent Findings
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