Three-component stereoselective synthesis of spirooxindole derivatives

Caspian Isinglass, a versatile and sustainable biocatalyst for domino synthesis of spirooxindoles and spiroacenaphthylenes in water

“…It has been reported that sharing the third-carbon atom of indole in the formation of spirooxindole derivatives highly enhances the biological activity [16][17][18][19]. Compounds with spiro skeleton have shown both constitute subunits in numerous alkaloids and are templates for drug discovery which have been used as scaffolds for combinatorial libraries [20][21][22].…”

SnO nanoparticles: a robust and reusable heterogeneous catalyst for the synthesis of 3,4,5-substituted furan-2(5H)-ones

“…Thus, multicomponent reactions play a significant role in the organic and medicinal synthesis [13][14][15][16][17][18]. The possibility of performing multicomponent reactions under mild conditions with a heterogeneous catalyst could enhance their effectiveness from economic and ecological points of view.…”

ZrOCl2/nano TiO2 as an Efficient Catalyst for the One Pot Synthesis of Naphthopyranopyrimidines Under Solvent-free Conditions

“…Undoubtedly, the synthesis of naphthopyranopyrimidines through multicomponent reactions (MCRs) has been paid much attention due to excellent synthetic efficiency, inherent atom economy, procedural simplicity and environmental friendliness. [7][8][9][10][11] The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for environmentally clean synthesis which involves reduction or elimination of the use or generation of hazardous chemicals. [12][13] The possibility of performing multicomponent reactions under solvent-free conditions with a heterogeneous catalyst could improve their cost-effectiveness and ecological acceptability.…”