Three-Component Condensation of 1,2,4-Triazol-3-amine with Cyclohexanone and ortho-Substituted Benzaldehydes

Vasil’kova, N. O.; Anis’kov, A. A.; Sorokin, V. V.; Кривенько, А. П.

doi:10.1134/s1070428018060179

Cited by 3 publications

(2 citation statements)

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“…Fused aryl‐substituted hexahydrotriazoloquinazolines 112 and octahydrotriazoloquinazolines 113 were obtained via three‐component condensation of 1,2,4‐triazol‐3‐amine with cyclohexanone and ortho ‐substituted benzaldehydes as indecated in Scheme 72 [82] …”

Section: Triazolopyrimidine Synthesismentioning

confidence: 99%

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Different Synthetic Methods for the Preparation of Triazolopyrimidines and their Biological Profile

et al. 2023

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One or more nitrogen‐containing molecules constitute an important class of heterocyclic compounds in organic synthesis, due to their reactivity and their presence in many molecules of natural, human or plant origin. These nitrogenous heterocycles play an essential role in various scientific domains, whether they are chemical, biological or pharmacological. N‐heterocycles are the privileged source of many research topics developed by several groups of researchers. Thus, different methods have been developed to access these heterocyclic compounds with nitrogenous rings, such as triazolopyrimidines. In this review, a bibliographic study summarizing the pharmacological importance of the triazolo[1,5‐a]pyrimidine ring, the different synthesis routes of these derivatives as well as their reactivity was reported.

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Section: Triazolopyrimidine Synthesismentioning

confidence: 99%

“…with cyclohexanone and ortho-substituted benzaldehydes as indecated in Scheme 72. [82] Jashnani et al [83] described a novel ionic liquid used [Hpi]HSO 4 ( ). [84] This reaction was carried out in DMF at 90 °C under stirring during 12 hours.…”

Section: Chemistryselectmentioning

confidence: 99%