Different Synthetic Methods for the Preparation of Triazolopyrimidines and their Biological Profile

Abstract

One or more nitrogen‐containing molecules constitute an important class of heterocyclic compounds in organic synthesis, due to their reactivity and their presence in many molecules of natural, human or plant origin. These nitrogenous heterocycles play an essential role in various scientific domains, whether they are chemical, biological or pharmacological. N‐heterocycles are the privileged source of many research topics developed by several groups of researchers. Thus, different methods have been developed to access these heterocyclic compounds with nitrogenous rings, such as triazolopyrimidines. In this review, a bibliographic study summarizing the pharmacological importance of the triazolo[1,5‐a]pyrimidine ring, the different synthesis routes of these derivatives as well as their reactivity was reported.

A review on pyrimidine‐based derivatives: Synthesis and their biological application

“…Pyrimidine-containing heterocycles exhibit a wide range of biological functions and are becoming a significant target for biological purposes. Many analyses are available, underlining the biological significance of this pattern [80][81][82]. In this review, we compiled a few notable activities of pyrimidine derivatives, including their applications as antibacterial, antimicrobial, antifungal, anti-inflammatory, antioxidant, anticancer, and antitumor agents.…”

Dihydroazolopyrimidines: Past, Present and Perspectives in Synthesis, Green Chemistry and Drug Discovery

“…Dihydropyrimidines anellated by an azole ring have been known since the 1980 s [11][12][13][14][15][16][17][18][19] and particular aspects of their chemistry have been described in several our reviews [20][21][22][23][24][25][26][27][28][29] and by other groups. [30,31] Since we are concerned with logical coherence, we considered it appropriate to provide a brief analysis of the most common result and only a few specific examples from previous work in this section of this review, therefore, most of the schemes in the section are of a general type.…”

Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines

“…Some examples of Biginelli-like reactions for the synthesis of the TZP scaffold that combine aldehydes, compounds with an active methylene group, and polyfunctional aminotriazoles have been reported in the literature (readers are directed to reviews), 3,12–16 mainly furnishing C-2 unsubstituted TZP derivatives, such as 4,5,6,7-tetrahydro-TZPs, 17 4,7-dihydro-TZPs, 18,19 and aromatic TZP analogues 20 (Fig. 1 – general structures I–IV).…”