Three cases of solar urticaria successfully treated with omalizumab

Baliu-Piqué, Carola; Peiró, Paula Aguilera

doi:10.1111/jdv.13001

Cited by 35 publications

(31 citation statements)

References 9 publications

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“…One of the hypotheses is that a UV‐induced photoallergen is recognised by IgE bound to cutaneous MCs, which then induces their degranulation and histamine release in response to UV. This notion is supported by the fact that the injection of autologous preirradiated serum into the skin of patients with SU can lead to a whealing as well as recent reports that anti‐IgE treatment with omalizumab can be of benefit in patients with SU …”

Section: The Role Of Mast Cells In Uv‐driven Diseasesmentioning

confidence: 86%

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Siiskonen

Smorodchenko

Krause

et al. 2017

Experimental Dermatology

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Mast cells (MCs) are well known as versatile effector cells in allergic reactions and several other immune responses. Skin MCs and cutaneous MC responses are subject to the effects of environmental factors including ultraviolet radiation (UVR). Numerous studies have assessed the effects of UVR on MCs, in vitro and in vivo. Interestingly, UVR seems to have variable effects on non-activated and activated mast cells. In general, UV therapy is beneficial in the treatment of urticaria and mastocytosis, but the effects are variable depending on treatment regimen and type of UVR. Here, we review and summarise key reports from the older and current literature on the crosstalk of UVR and skin MCs. Specifically, we present the literature and discuss published reports on the effects of UVR on skin MCs in rodents and humans. In addition, we review the role of MCs in UVR-driven skin diseases and the influence of UV light on MC-mediated skin diseases. This summary of our current understanding of the interplay of skin MCs and UVR may help to improve the management of patients with urticaria and other MC disorders, to identify current gaps of knowledge, and to guide further research. K E Y W O R D Scancer, mast cell, ultraviolet radiation, urticaria

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Section: The Role Of Mast Cells In Uv‐driven Diseasesmentioning

confidence: 86%

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Siiskonen

Smorodchenko

Krause

et al. 2017

Experimental Dermatology

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“…It was also recently proposed that IgE plays a role in the amplification of inflammation favouring the infiltration of immune cells into secondary lymphoid organs [25,26]. Moreover, OmAb has been reported to control physical urticarias [32][33][34]. In the case of chronic urticaria, the exact mechanism of OmAb is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Comparable actions of omalizumab on mast cells and basophils

Serrano‐Candelas

Martín

Valero

et al. 2015

Clin Experimental Allergy

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“…En la literatura existen reportes de casos y series de casos con urticaria solar refractaria en los que se registran buenos resultados con este medicamento. 10 Si bien hasta el momento del presente informe la paciente no había recibido omalizumab, consideramos puede ser una opción de acuerdo con la evolución de los síntomas.…”

Section: Discussionunclassified

Urticaria solar. Reporte de un caso y revisión de la literatura

Raigosa

Toro

Sánchez

2017

RAM

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Este artículo debe citarse como: Raigosa M, Toro Y, Sánchez J. Urticaria solar. Reporte de un caso y revisión de la literatura. Rev Alerg Mex. 2017;64(3):371-375 AbstractBackground: Solar urticaria is a rare type of inducible urticaria characterized by wheal and erythema formation shortly after exposure to sunlight or to an artificial light source; its pathophysiology is not yet entirely understood. The treatment of choice, in addition to exposure avoidance, consists in antihistamine administration. Clinical case: This is the case of a 27-year-old woman with no personal history of allergic diseases and with a 2-year history of erythema and wheals in photo-exposed areas associated with sunlight exposure for periods longer than 10 minutes. A provocation test was carried out; she was started on fexofenadine at 4-fold the standard dose (720 mg/day). Six weeks later, a new challenge was carried out without the antihistamine being discontinued; the reaction was less severe, but she continued with erythema for the first 60 minutes post-exposure. After 3 months on high-dose antihistamines, she referred marked improvement in her quality of life and tolerance to brief sunlight exposure (for less than 15 minutes). Conclusions: Solar urticaria is a rare process but with a high impact on the patient. The use of antihistamines partially relieves symptoms and allows better tolerance to lighting expositions.

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Three cases of solar urticaria successfully treated with omalizumab

Cited by 35 publications

References 9 publications

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Comparable actions of omalizumab on mast cells and basophils

Urticaria solar. Reporte de un caso y revisión de la literatura

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