Three Cases of Chemotherapy‐induced Acral Erythema

Komamura, Hiromi; Higashiyama, Mari; Hashimoto, Koji; Takeda, Kohsuke; Kimura, Hiromi; Tani, Yasuhiro; Ogawa, Hiroyasu; Yoshikawa, Kunihiko

doi:10.1111/j.1346-8138.1995.tb03354.x

Cited by 16 publications

(4 citation statements)

References 30 publications

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“…A regular application of topical petroleum-lanolin ointment base with hydroxyquinolone sulphate three times per day was rendered effective, also reported by Chin et al (2001). Topical corticosteroids have an effective role in the management of symptoms however these may also cause thinning of the skin (Komamura et al, 1995;Vakalis et al, 1998), which was observed in some female patients in our study. The patients were also prescribed with Vitamin B6, which is known to be highly effective in both the prophylaxis and control of symptoms (Fabian et al, 1990).…”

Section: Discussionmentioning

confidence: 71%

Comparative Assessment of Skin and Subcutaneous Toxicity in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX

Bano¹,

Najam²,

Mateen³

2013

Asian Pacific Journal of Cancer Prevention

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Objective: The study was designed to assess the skin and subcutaneous toxicity in patients with advanced colorectal carcinoma treated with four different schedules of FOLFOX. Methods: The patients with histologically confirmed advanced colorectal carcinoma (CRC) were included in the study as per specified inclusion criteria. Toxicity was graded according to CTC v2.0. The frequency of grade 3 and 4 adverse effects were comparatively assessed in each treatment arm. Results: Very severe toxicity was attributed to the FOLFOX7 schedule. The difference between the incidence rate of grade 4 toxicity with all other grades for all parameters of skin and subcutaneous toxicity was highly significant (p=0.00<0.001). Grade 4 hand and foot syndrome was reported only in the FOLFOX7 treatment arm. The most frequent adverse symptom of skin and subcutaneous toxicity reported in the patients treated with modified schedule of FOLFOX was pruritus (grade 1). Frequency and onset of skin and subcutaneous toxic symptoms like alopecia (p=0.000), nail discoloration (p=0.021) and pruritis (p=0.000) was significantly different in each FOLFOX treatment arm. A few cases of oncholysis were also reported in the FOLFOX7 treatment arm. Hand and foot syndrome was fast progressing in patients with grade 1 toxicity. Conclusion: Higher frequency and severity of hand and foot syndrome and pruritus wasa found in the FOLFOX7 treatment arm. Skin and subcutaneous toxicity was comparatively low in the FOLFOX6 treatment arm.

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Section: Discussionmentioning

confidence: 71%

Comparative Assessment of Skin and Subcutaneous Toxicity in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX

Bano¹,

Najam²,

Mateen³

2013

Asian Pacific Journal of Cancer Prevention

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“…It is important to make patients with CIAE aware of the natural course in order to prevent them from becoming overly anxious (8). CIAE, especially erythrodysesthesia, is usually so painful that it requires treatment such as systemic or topical steroids (5, 6, 9), elevation of the legs (8), and application of cold compression to the lesion (5, 9). Treatment with steroid ointment using ODT was effective and prophylactic for the ertyhrodysesthesia in our case.…”

Section: Discussionmentioning

confidence: 99%

A Case of Docetaxel‐Induced Erythrodysesthesia

Katoh

Kadota

Nishimura

2004

The Journal of Dermatology

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Chemotherapy-induced acral erythema (CIAE) is a rare cutaneous reaction to high-dose chemotherapy, clinically featuring painful erythema on the palms and soles. Docetaxel (Taxotere), an anticancer agent, is known to cause various reactions, including CIAE. We experienced a case of docetaxel-induced acral erythema with facial edematous erythema that coincidentally emerged and regressed with appearance and disappearance of the acral lesions. Docetaxel-induced acral erythema exhibits a widespread distribution and intense sensations of intolerable pain and numbness. Therefore, some authors use the term erythrodysesthesia instead of acral erythema. We speculated that the facial erythema might be part of the spectrum of erythrodysesthesia. Our case was finally diagnosed as decetaxel-induced erythrodysesthesia. Although CIAE is self-limiting, the patients frequently require treatment because of intolerable pain. Reported treatments for CIAE include topical or systemic steroids, elevation of the legs, and application of cold compression to the lesion. In our case, application of a steroid ointment with the occlusive dressing technique (ODT) alleviated the clinical manifestations and was also prophylactic for the erythrodysesthesia.

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“…Furthermore, topical corticosteroids have been useful for the prophylaxis and treatment of HFS. However, that treatment in capecitabine-associated HFS up to date is not proven [6]. Although its efficacy has not been proven in clinical studies, certain authors report on the use of prophylactic or therapeutic pyridoxine supplementation for the prevention or minimisation HFS lesions [7].…”

Section: Introductionmentioning

confidence: 99%

Topical henna for capecitabine induced hand–foot syndrome

Yücel

Gönüllü

2007

Invest New Drugs

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Capecitabine is a chemotherapeutic drug for use in cancers. Hand-foot syndrome (HFS) is side effect of capecitabine which can lead the cessation of the therapy or dose reduction. Henna (Lawsonia inermis) is a traditionally used plant of Middle-East that is applied on hands and feet. Some of cancer patients in capecitabine treatment who developed HFS, we recommended to apply henna. In these patients, six patients were grade 3 HFS and four were grade 2 HFS. Complete response (CR) were seen in four of grade 3 HFS and all of grade 2; two grade 3 HFS improved to grade 1. So far, in the chemotherapy, there was no need of dose reduction and also no side effect of henna seen. Clinical improvement in these patients may relate to anti-inflammatory, antipyretic and analgesic effects of henna. Prospective studies are needed to show this therapeutic effect of henna.

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Three Cases of Chemotherapy‐induced Acral Erythema

Cited by 16 publications

References 30 publications

Comparative Assessment of Skin and Subcutaneous Toxicity in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX

Comparative Assessment of Skin and Subcutaneous Toxicity in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX

A Case of Docetaxel‐Induced Erythrodysesthesia

Topical henna for capecitabine induced hand–foot syndrome

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