A Case of Docetaxel‐Induced Erythrodysesthesia

Abstract

Chemotherapy-induced acral erythema (CIAE) is a rare cutaneous reaction to high-dose chemotherapy, clinically featuring painful erythema on the palms and soles. Docetaxel (Taxotere), an anticancer agent, is known to cause various reactions, including CIAE. We experienced a case of docetaxel-induced acral erythema with facial edematous erythema that coincidentally emerged and regressed with appearance and disappearance of the acral lesions. Docetaxel-induced acral erythema exhibits a widespread distribution and intense sensations of intolerable pain and numbness. Therefore, some authors use the term erythrodysesthesia instead of acral erythema. We speculated that the facial erythema might be part of the spectrum of erythrodysesthesia. Our case was finally diagnosed as decetaxel-induced erythrodysesthesia. Although CIAE is self-limiting, the patients frequently require treatment because of intolerable pain. Reported treatments for CIAE include topical or systemic steroids, elevation of the legs, and application of cold compression to the lesion. In our case, application of a steroid ointment with the occlusive dressing technique (ODT) alleviated the clinical manifestations and was also prophylactic for the erythrodysesthesia.

Chemotherapeutic agents and the skin: An update

“…154 Acral erythema, or handefoot syndrome, is a common and well documented side effect of docetaxel therapy. [155][156][157][158][159] In fact, docetaxel, along with cytarabine, doxorubicin, liposomal doxorubicin, and 5-fluorouracil, is most frequently associated with the condition. 160 Clinically, there are discrete erythematous or violaceous patches or edematous plaques that arise on the palms and soles and may progress to involve the dorsal surfaces of the hands (Fig 6) and feet.…”

Reações tegumentares adversas relacionadas aos agentes antineoplásicos: parte I

“…General measures should be taken, such as reduction or suspension of the drug, longer intervals between chemotherapy cycles, dressings, elevation of the extremity, cold compresses, analgesic medication and emollients. 54 As a specific treatment, pyridoxine can be used if fluorouracil, liposomal doxorubicin, doxorubicin, docetaxel and etoposide have been administered; hand cooling (docetaxel); oral corticosteroids (doxorubicin, fluorouracil); strong topical corticosteroids (liposomal doxorubicin, cisplatin and fluorouracil), and topical DMSO at 99% (liposomal doxorubicin). Symptoms can be relieved with lesion care to prevent infection and elevation of the limb to reduce the edema.…”

Hand-Fuß-Syndrom bei einem Patienten unter Capecitabin-Therapie

“…Das HFS verursacht typischerweise ein Taubheitsgefühl und Kribbeln, akrale Erytheme, Schwellung und selten Bullae. Das HFS ist eine nicht seltene Nebenwirkung einer Therapie von Capecitabin (N 4 -Pentyloxycarbonyl-5'-deoxy-5-fluorocytidin), Doxorubicin, liposomalem Doxo rubicin, Troxacitabine, Irinotecan, Methotrexat, 6-Mercaptopurin, Hydroxy urea, Etoposid, Cytarabin, Gemcitabin und Vinorelbin [6,8,13,14,16,18,19]. Das verwandte Anthrazyklin liposomales Daunorubicin wurde in der Literatur bislang nicht mit der HFS bzw.…”