Three anti-tumor saponins from Albizia julibrissin

A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents

“…In comparison to the chemotherapeutic drug Adriamycin, julibroside J 30 (33) was more cytotoxic (92% inhibition of the cell number) than Adriamycin (76% inhibition of the cell number) against HeLa. Likewise, more PC-3 M-1E8 cells were killed (94% inhibition of the cell number) with julibroside J 31 (34) in comparison with Adriamycin (91% inhibition of the cell number) assayed by MTT method (Zheng et al 2006). In the SRB method, all three compounds showed good inhibitory activities against the three cancer cell lines PC-3 M-1E8, MDA-MB-435 and HeLa with 80%, 75%, and more than 80% inhibition, respectively.…”

“…At 10.0 lM, julibroside J 28 (29) reduced cell number by about 70% , and at 10 lg/ml julibroside J 21 (31) showed marked inhibitory action with 80% inhibition of the cell number (Zou et al 2006). Furthermore, julibrosides J 29 , J 30 and J 31 (32-34) showed significant inhibitory activities against Human prostate cancer cell (PC-3 M-1E8), MDA-MB-435, and Human cervical carcinoma (HeLa) cancer cell lines at 10 lM assayed by SRB and MTT methods (Zheng et al 2006). In comparison to the chemotherapeutic drug Adriamycin, julibroside J 30 (33) was more cytotoxic (92% inhibition of the cell number) than Adriamycin (76% inhibition of the cell number) against HeLa.…”

Acaricidal activity and chemical composition of essential oil derived from theAlbizziae julibrissinbarks

“…Actually, species-specific differences have been studied for a variety of mite species (Won et al 2006, Jung et al (2003 reported that the methanol extract of the A. julibrissin exhibited strong antioxidant activity. Furthermore, the butanol extract from the A. julibrissin barks exhibited significant inhibitory activity against human tumor cell lines (Zheng et al 2006). Previous studies have reported that the main compound of A. julibrissin, hexanoic acid, has the fumigant activity to Drosophila melanogaster (Dettner et al 1992).…”

Molecular analysis of Albizia species using AFLP markers for conservation strategies

“…regarded as astringent, and used in the treatment of piles, diarrhea and gonorrhea (Anonymous 1989). It has been recently demonstrated that three saponin extracts from A. julibrissin acts as antitumorals by the induction of apoptosis in certain cell types (Zheng et al 2006) and butanol extract from the bark of A. julibrissin has cytotoxic effect on human acute leukemia junket T-cells (Won et al 2006). Some Albizia species are regarded as a potential fodder resource (Stewart and Dunsdon 2000).…”