Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism

Madsen, Mogens; Mahon, Brenda Mc; Andersen, S. B.; Siebner, Hartwig R.; Knudsen, Gitte M.; Fisher, Patrick M.

doi:10.1093/scan/nsv098

Cited by 39 publications

(22 citation statements)

References 84 publications

(97 reference statements)

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“…Nejad et al, 2013). Individuals with high levels of neuroticism have been found to have decreased connectivity between the amygdala and temporal pole (Aghajani et al, 2014;Madsen et al, 2016). Neuroticism has previously been found to be associated with depressive symptoms and mediated by brooding rumination in MDD (Merino, Senra, & Ferreiro, 2016).…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Satyshur

Layden

Gowins

et al. 2018

Cogn Affect Behav Neurosci

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Ruminative thinking is related to an increased risk for major depressive disorder (MDD) and perpetuates negative mood states. Rumination, uncontrollable negative thoughts about the self, may comprise both reflective and brooding components. However, only brooding rumination is consistently associated with increased negativity bias and negative coping styles, while reflective rumination has a less clear relationship with negative outcomes in healthy and depressed participants. The current study examined seed-to-voxel (S2.V) resting-state functional connectivity (FC) in a sample of healthy (HC) and depressed (MDD) adult women (HC: n=50, MDD: n=33). The S2V FC of six key brain regions, including the left and right amygdala, anterior and posterior cingulate cortex (ACC, PCC), and medial and dorsolateral prefrontal cortices (mPFC, dlPFC), was correlated with self-reported reflective and brooding rumination. Results indicate that HC and MDD participants had increased brooding rumination associated with decreased FC between the left amygdala and the right temporal pole. Moreover, reflective rumination was associated with distinct FC of the mPFC, PCC, and ACC with parietal, occipital, and cingulate regions. Depressed participants, compared with HC, exhibited decreased FC between the PCC and a region in the right middle frontal gyrus. The results of the current study add to the understanding of the neural underpinnings of different forms of self-related cognition-brooding and reflective rumination-in healthy and depressed women.

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Section: Discussionmentioning

confidence: 99%

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Satyshur

Layden

Gowins

et al. 2018

Cogn Affect Behav Neurosci

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“…Taking the amygdala as a seed, given its role in personality and cognition, we found different connections supporting internal vs. external LOC that were both located in the cingulate cortex and prefrontal cortex (PFC). The impaired integrity of functional and structural connectivity of both amygdala-PFC and amygdala-ACC pathways have been correlated with neuroticism (Haas, Omura, Constable, & Canli, 2007; Madsen, et al, 2016; McIntosh, et al, 2013; Xu & Potenza, 2012). In addition, disruption of amygdala-PFC connectivity is related to trait anxiety (Kim & Whalen, 2009).…”

Section: Discussionmentioning

confidence: 99%

Amygdala functional connectivity is associated with locus of control in the context of cognitive aging

et al. 2017

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Locus of control (LOC) measures the extent to which individuals perceive control over their lives. Those with a more “internal” LOC feel self-sufficient and able to determine important aspects of their own future, while those with a more “external” LOC feel that their lives are governed by events beyond their control. Reduced internal LOC and increased external LOC have been found in cognitive disorders, but the neural substrates of these control perceptions are yet unknown. In the present study, we explored the relationship between amygdala functional connectivity and LOC in 18 amnestic mild cognitive impairment (MCI) and age-, sex-, and education-matched, 22 cognitively healthy controls (HC). Participants completed cognitive challenge tasks (Stroop Word Color task and Dual 1-back) for 20 minutes, and underwent resting-state functional magnetic resonance imaging immediately before and after the tasks. We found significantly lower internal LOC and higher external LOC in the MCI group than the HC group. Compared to HC, MCI group showed significantly stronger positive associations between internal LOC and baseline right amygdala connections (including right middle frontal gyrus and anterior cingulate cortex), and stronger negative associations between internal LOC and change of these right amygdala connections. Across all participants, external LOC explained the relationships between associations of another set of right amygdala connections (including middle cingulate cortex and right superior frontal gyrus), both at baseline and for change, and performance in the cognitive challenge tasks. Our findings indicate that the right amygdala networks might be critical in understanding the neural mechanisms underlying LOC’s role in cognitive aging.

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“…We used psychophysiological interaction (PPI) analyses (Friston et al , 1997; McLaren et al , 2012; Madsen et al , 2015) to assess the provocation-associated functional connectivity with seed regions in either amygdala or striatum, using the contrast Provocations > Option 1. Bilateral amygdala and striatum seeds were defined based on clusters significantly responsive to provocations across subjects (Table 2).…”

Section: Methodsmentioning

confidence: 99%

Violent offenders respond to provocations with high amygdala and striatal reactivity

Cunha-Bang

Fisher

Hjordt

et al. 2017

Social Cognitive and Affective Neuroscience

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The ability to successfully suppress impulses and angry affect is fundamental to control aggressive reactions following provocations. The aim of this study was to examine neural responses to provocations and aggression using a laboratory model of reactive aggression. We used a novel functional magnetic resonance imaging point-subtraction aggression paradigm in 44 men, of whom 18 were incarcerated violent offenders and 26 were control non-offenders. We measured brain activation following provocations (monetary subtractions), while the subjects had the possibility to behave aggressively or pursue monetary rewards. The violent offenders behaved more aggressively than controls (aggression frequency 150 vs 84, P = 0.03) and showed significantly higher brain reactivity to provocations within the amygdala and striatum, as well as reduced amygdala-prefrontal and striato-prefrontal connectivity. Amygdala reactivity to provocations was positively correlated with task-related behavior in the violent offenders. Across groups, striatal and prefrontal reactivity to provocations was positively associated with trait anger and trait aggression. These results suggest that violent individuals display abnormally high neural sensitivity to social provocations, a sensitivity related to aggressive behavior. These findings provide novel insight into the neural pathways that are sensitive to provocations, which is critical to more effectively shaped interventions that aim to reduce pathological aggressive behavior.

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Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism

Cited by 39 publications

References 84 publications

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Amygdala functional connectivity is associated with locus of control in the context of cognitive aging

Violent offenders respond to provocations with high amygdala and striatal reactivity

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