Thorakales Aortenaneurysma

Abstract

Thoracic aortic aneurysms (TAA) are the most common pathology of the thoracic aorta. TAA are occuring with increasing incidence (10.4 cases per 100,000 person years) and are most commonly caused by atherosclerosis. There are also hereditary, inflammatory and infectious pathogenic factors. A TAA initially causes no symptoms and is therefore usually diagnosed as an incidental finding. Computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are the diagnostic tools of choice for diagnosis and treatment planning. The mean growth rate of TAA is estimated to be 0.10 to 0.42 cm per year. A diameter of 6 cm is considered to be an indication for surgery. Besides medicinal therapy, thoracic endovascular aortic repair (TEVAR) nowadays offers certain advantages compared to conventional open repair. The same applies to the region of the aortic arch. Follow up examinations after TEVAR are of major importance in order to ensure long-term therapeutic success.

Proteomics in aortic aneurysm – What have we learnt so far?

“…AA is usually a slowly progressing disease that can go undetected for decades and might only be discovered accidentally during imaging for other pathologies such as spinal problems. However, fatal complications may occur, namely aneurysm rupture and dissection . The interplay of several factors can expedite the progression of AA such as initial aortic size, the presence of family history and cardiovascular risk factors, in particular age, male gender and smoking .…”

Circ_0008285 silencing suppresses angiotensin II‐induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via miR‐150‐5p/BASP1 axis

“…Thoracic aortic aneurysm (TAA) is the most common pathology of the thoracic aorta, resulting from the enlargement or dilation in the weakened area in the wall of a blood vessel. TAA is a rare event with an incidence of 5.9 cases per 100 000 persons annually; however, it has an extremely high mortality upon rupture 1–3 . Vascular smooth muscle cells (VSMCs) are the major component of the aortic middle layer, the abnormal number or function of which can lead to structural reconstruction of vascular wall, weaken elasticity and strengthen frigidity 4 .…”

“…TAA is a rare event with an incidence of 5.9 cases per 100 000 persons annually; however, it has an extremely high mortality upon rupture. 1 , 2 , 3 Vascular smooth muscle cells (VSMCs) are the major component of the aortic middle layer, the abnormal number or function of which can lead to structural reconstruction of vascular wall, weaken elasticity and strengthen frigidity. 4 TAA is pathologically characterized by the disruption of VSMCs and destruction/remodeling of the vascular extracellular matrix.…”