Thoracic imaging outcomes in COVID-19 survivors

Alqahtani, Jaber S; Alghamdi, Saeed M; Aldhahir, Abdulelah M.; Althobiani, Malik; Raya, Reynie Purnama; Oyelade, Tope

doi:10.4329/wjr.v13.i6.149

Cited by 3 publications

(4 citation statements)

References 47 publications

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“…These percentages seemed to be higher than those reported for other coronaviruses or H1N1 and are currently termed “long-COVID”. Despite these findings emerging as a key research topic and showing a significant correlation with disease severity, further investigations are required, due to both the heterogeneity of studies and the short follow-up [ 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Co-Infections and Superinfections in COVID-19 Critically Ill Patients Are Associated with CT Imaging Abnormalities and the Worst Outcomes

et al. 2022

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Background: Bacterial and fungal co-infections and superinfections have a critical role in the outcome of the COVID-19 patients admitted to the Intensive Care Unit (ICU). Methods: The present study is a retrospective analysis of 95 patients admitted to the ICU for COVID-19-related ARDS during the first (February–May 2020) and second waves of the pandemic (October 2020–January 2021). Demographic and clinical data, CT imaging features, and pulmonary and extra-pulmonary complications were recorded, as well as the temporal evolution of CT findings when more than one scan was available. The presence of co-infections and superinfections was registered, reporting the culprit pathogens and the specimen type for culture. A comparison between patients with and without bacterial and/or co-infections/superinfections was performed. Results: Sixty-three patients (66.3%) developed at least one confirmed co-infection/superinfection, with 52 (82.5%) developing pneumonia and 43 (68.3%) bloodstream infection. Gram-negative bacteria were the most common co-pathogens identified and Aspergillus spp. was the most frequent pulmonary microorganism. Consolidations, cavitations, and bronchiectasis were significantly associated with the presence of co-infections/superinfections (p = 0.009, p = 0.010 and p = 0.009, respectively); when considering only patients with pulmonary co-pathogens, only consolidations remained statistically significative (p = 0.004). Invasive pulmonary aspergillosis was significantly associated with the presence of cavitations and bronchiectasis (p < 0.001). Patients with co-infections/superinfections presented a significantly higher mortality rate compared to patients with COVID-19 only (52.4% vs. 25%, p = 0.016). Conclusions: Bacterial and fungal co-infections and superinfections are frequent in COVID-19 patients admitted to ICU and are associated with worse outcomes. Imaging plays an important role in monitoring critically ill COVID-19 patients and may help detect these complications, suggesting further laboratory investigations.

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Section: Discussionmentioning

confidence: 99%

Co-Infections and Superinfections in COVID-19 Critically Ill Patients Are Associated with CT Imaging Abnormalities and the Worst Outcomes

et al. 2022

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Section: Introductionmentioning

confidence: 99%

“…Although clinical and imaging evaluations provide a basis for a useful assessment of the patient's condition, they cannot offer specific quantitative data on respiratory function recovery. Therefore, to address the increasing need to track patients' respiratory function over time, considerable interest in applying respiratory function tests and assessing gas exchange dynamics is growing 11–17 …”

Section: Introductionmentioning

confidence: 99%

“…Therefore, to address the increasing need to track patients' respiratory function over time, considerable interest in applying respiratory function tests and assessing gas exchange dynamics is growing. [11][12][13][14][15][16][17] Previous studies on this topic produced very interesting results. However, interpretation was difficult due to the high complexity of the pathophysiological background underlying the COVID-19 lung infection dynamics and the lack of a COVID-dedicated and standardised interpretative approach.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of respiratory function and exercise tolerance at 4–6 months after COVID‐19 infection in patients with pneumonia of different severity

Pini

Montori

Guerini

et al. 2022

Internal Medicine Journal

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Background The evaluation of COVID‐19 systemic consequences is a wide research field in which respiratory function assessment has a pivotal role. However, the available data in the literature are still sparse and need further strengthening. Aim To assess respiratory function 4–6 months after hospital discharge based on lung disease severity in patients who overcome COVID‐19 pneumonia. Methods Patients hospitalised either in the Internal Medicine Department (IMD) for moderate to severe disease or in the Intensive Care Unit (ICU) for critical disease underwent spirometry with maximal flow‐volume curve, lung volumes, lung diffusion capacity (DL CO ) and six‐minute walking test (6‐MWT). Results Eighty‐eight patients were analysed: 40 from the IMD and 48 from the ICU. In both cohorts, there was a greater prevalence of male patients. In the IMD cohort, 38% of patients showed at least one altered respiratory parameter, while 62% in the ICU cohort did so ( P < 0.05). Total lung capacity (TLC) and DL CO were the most frequently altered parameters: 15% and 33% from IMD versus 33% and 56% from ICU, respectively ( P < 0.05). In IMD patients, 5% had only restrictive deficit, 22% had only lung diffusion impairment and 10% had both. In ICU patients, 6% had only restrictive deficit, 29% had only lung diffusion impairment and 27% had both ( P < 0.05). ICU patients showed a higher frequency of abnormal 6‐MWT ( P < 0.05). Conclusion Lung function tests and 6‐MWT are highly informative tools for monitoring the negative consequences of COVID‐19 pneumonia, which were more frequent and more complex in patients discharged from ICU.

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Gastrointestinal Imaging Findings in the Era of COVID-19: A Pictorial Review

Mavropoulou,

Psoma,

Papachristodoulou

et al. 2023

Medicina

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The potentially fatal COVID-19 pandemic has been associated with a largespectrum of clinical presentations. Beyond the classical pulmonary manifestations, gastrointestinal tract-related symptoms suchas nausea, diarrhea, abdominal distention and pain have been observed in patients, as a consequence of the binding of SARS-CoV-19 to Angiotensin-converting Enzyme 2 (ACE2) receptors in the gastrointestinal (GI) tract. The early recognition ofspecific imaging features, including hepatobiliary involvement, pancreatic involvement, development of solid organ infarcts, ischemic bowel changes and vascular occlusion, plays a key role through the course of the disease. Also, suspicious symptoms, especially in critically ill patients with clinical and biochemical markers of hypovolemia, necessitate timely imaging for bleeding complications. The aim of this pictorial review is to illustrate the spectrum of the GIimaging findings in patients with COVID-19. Awareness of diagnostic imaging hallmarks is crucial to optimize the management of these patients.

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Thoracic imaging outcomes in COVID-19 survivors

Cited by 3 publications

References 47 publications

Co-Infections and Superinfections in COVID-19 Critically Ill Patients Are Associated with CT Imaging Abnormalities and the Worst Outcomes

Co-Infections and Superinfections in COVID-19 Critically Ill Patients Are Associated with CT Imaging Abnormalities and the Worst Outcomes

Assessment of respiratory function and exercise tolerance at 4–6 months after COVID‐19 infection in patients with pneumonia of different severity

Gastrointestinal Imaging Findings in the Era of COVID-19: A Pictorial Review

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