Thoracic and abdominal mesothelioma in a dog: a cytologist’s view

Martins, Danieli Brolo; Souza, Giancarlo Santini de; Pedrozo, Josaine C. S. R.; Mazzanti, Cinthia M.; Mazzantí, Alexandre; Beckmann, Diego Vilibaldo; Santos, Rosmarini Passos dos; Graça, Dominguita Lühers; Lopes, Sonia T.A.

doi:10.1007/s00580-011-1177-8

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…However, a higher cellularity and presence of greater clusters of cells are seen in neoplastic process of mesothelium (15). In this report, a small number of solitary spindle cells with high pleomorphism were also seen, which correspond to the proliferation of connective tissue.…”

Section: Discussionmentioning

confidence: 65%

“…In that case, the tumors present solid and papillary pattern with large amount of connective tissue, and the metastases were seen in ileocecal lymph nodes (4). In a dog with mesothelioma in pleura and peritoneum, the pericardium was not affected, and the lymph nodes were not investigated (15). Although mesothelioma may be transferred by contaminated instruments (13), there was no evidence of using the same needle in both cavities in this case.…”

Section: Discussionmentioning

confidence: 94%

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Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report

Toledo¹,

Gonçalves²,

Toscano³

et al. 2018

BJVP

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Toledo, et al.; Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report. Braz J Vet Pathol, 2018, 11(2), 68 -75 DOI: 10.24070/bjvp.1983 Abstract Mesothelioma is a rare tumor of mesothelium and usually spread by implantation in the same cavity it arises. Regarding bovine mesotheliomas, the abdominal cavity is the most affected site. This article describes a case of diffuse papillary mesothelioma within both thoracic and abdominal cavity with nodal metastasis in an adult cow -based on cytology, histopathology, and immunohistochemical analysis. A 7-years-old cow, Nelore breed (Brazilian beef cattle), with clinical signs of tachypnea, abdominal distention, and positive jugular venous pulse was slaughtered and necropsied due to persistent weight loss. The main gross findings were several verrucous and yellowish nodules spread on pericardium, pleura, and peritoneum. Mediastinal lymph nodes were enlarged and hemorrhagic with multiples yellowish spots on cut surface. The diagnoses of diffuse mesothelioma with nodal metastasis was established and ratified by the microscopic analysis. Immunohistochemical results had strong positivity for cytokeratin and the Ki-67 showed proliferative index of 28%. Vimentin was positive only in the cells of fibrous tissue. In this case, the initial site of the mesothelioma was not recognized. Although it is a post-mortem study, cytology may be very helpful in vivo investigation. Equally important, is the IHC to better comprehend this tumor and its behavior.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 94%

Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report

Toledo¹,

Gonçalves²,

Toscano³

et al. 2018

BJVP

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“…Thoracocentesis was the prime treatment given to animal since this relieves respiratory distress and also provides time for cyotological examination (Martins et al, 2011). The dog was treated with Angiotensin Converting Enzyme (ACE) inhibitor enalapril (@ 0.5mg/kg/day, PO), diuretic furosemide (@ 4mg/kg PO), corticosteroid prednisolone (@ 0.5mg/kg, PO) along with pantaprazole (@ 2 mg/kg PO) for 10 days.…”

Section: Treatment and Discussionmentioning

confidence: 99%

Pleural Effusion due to Mesothelioma in a Dog-A Case Report

Mohanambal¹,

Mohan²,

Rajyalakshmi³

et al. 2020

Int.J.Curr.Microbiol.App.Sci

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“…4). The cytological analysis of the pleural fluid found to be rapid technique for accurate diagnosis of mesothelioma in certain situations (Martins et al, 2011).…”

Section: Case History a N D Observationsmentioning

confidence: 99%

Mesothelioma – Cytological Studies and Medical Management in a Non-Descript Dog – A Case Report

Sundararajan

Preethi

Gopal

et al. 2022

ijvsbt

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Mesotheliomas are tumors of low grade malignancy originating from mesothelial cells covering the coelomic cavities such as the pericardium, pleura, peritoneum and vaginal tunic (Seo et al., 2007). The three types of mesotheliomas are epithelial, fibrous (arcomatous) and biphasic (mixed). The epithelial form, which closely resembles the carcinoma and adenocarcinoma, is the most common type of mesothelioma in dogs (Echandi et al., 2007). Pleural effusion is one of the most classical characteristic feature of mesothelioma. They cause minimal tissue invasion and rarely metastasis to other regions (Vural et al., 2007). In addition to viral or genetic factors long term exposure to dusts such as asbestos, iron or silica plays a major role in the pathogenesis of this neoplasm. It is more common in older animals than younger animals (Echandi et al., 2007). The major clinical sign of this condition occurs due to the accumulation of fluid in the body cavities (Seo et al., 2007). The cytological analysis of the fluid helps to determine the cause of pleural effusion and to make rapid diagnosis (Martin et al., 2011). The morphology of the mesothelial cells are round to polygonal in outline, with anisocytosis, anisokaryosis, pleomorphic multi-nucleated cells, minimal eosinophilic or basophilic cytoplasm, mitosis, loose chromatin, evident nucleoli and ovoid to angulated vesicular nucleus (Martin et al., 2011).

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Thoracic and abdominal mesothelioma in a dog: a cytologist’s view

Cited by 4 publications

References 24 publications

Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report

Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report

Pleural Effusion due to Mesothelioma in a Dog-A Case Report

Mesothelioma – Cytological Studies and Medical Management in a Non-Descript Dog – A Case Report

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