Thirty‐two Years Experience in Management of Primary Tumours of the Vagina

Al-Kurdi, M.; Monaghan, John M.

doi:10.1111/j.1471-0528.1981.tb01770.x

Cited by 61 publications

(24 citation statements)

References 11 publications

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“…Regional lymph nodes that may be infiltrated by micrometastases can also be treated by this mode of therapy [22,30,43]. Retrospective studies revealed overall 5-year survival rates of about 40% for invasive tumors treated with external radiotherapy combined with brachytherapy [1,[27][28][29]38]. This rate is very comparable to our data, with a disease-specific survival of 41.7% after 5 years.…”

Section: Discussionsupporting

confidence: 78%

Long-Term Results of Radiotherapy in Primary Carcinoma of the Vagina

et al. 2009

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Background:The long-term results of radiotherapy in primary carcinoma of the vagina are not well defined. Patients and Methods: The treatment results of 41 patients with primary malignancies of the vagina were analyzed. The mean follow-up period was 77.3 months (2.3-404 months). The predominant histology was squamous cell carcinoma, FIGO stages I: n = 7 (17.1%), II: n = 13 (31.7%), III: n = 13 (31.7%), and IVa: n = 8 (19.5%). Radiotherapy was the primary treatment for all patients. None of the patients had undergone prior surgery for vaginal carcinoma. The majority of patients received pelvic irradiation, including treatment of the inguinal lymphatics (median dose: 50 Gy). 26 patients received additional intravaginal brachytherapy. Results: Overall, 21 patients (51.2%) achieved complete remission, 17 patients (41.5%) had partial responses, and three patients (7.3%) had no change or progressive disease. The total median survival of the analyzed patients was 41.3 months. The 1-year survival probability was 85.4%, the 5-year survival probability 40.6%, and the 10-year survival probability 27.2%. Univariate analysis revealed a survival advantage for earlier tumor stages (FIGO I and II) compared to advanced stages (FIGO III and IV), with a median survival of 58.1 months compared to 26.8 months. Treatment side effects were tolerable and easily managed. Conclusion: Definite radiotherapy is the treatment of choice for primary carcinomas of the vagina. Considering that primary malignancies of the vagina are typically diseases of the elderly, it should be noted that radiotherapy is especially well tolerated in this population. Langzeitergebnisse der Strahlentherapie beim primären VaginalkarzinomHintergrund: Die Langzeitergebnisse der Strahlentherapie beim primären Vaginalkarzinom sind nicht gut definiert. Patienten und Methodik: Die Behandlungsergebnisse von 41 Patientinnen mit primären Vaginalkarzinomen wurden analysiert. Der mittlere Nachbeobachtungszeitraum betrug 77,3 Monate (2,3-404 Monate). Histologisch lagen überwiegend Plattenepithelkarzinome vor, FIGO-Stadien I: n = 7 (17,1%), II: n = 13 (31,7%), III: n = 13 (31,7%), IVa: n = 8 (19,5%). Bei allen Patientinnen war die Strahlentherapie die primäre Behandlungsform, keine Patientin hatte sich vor Bestrahlungsbeginn einer chirurgischen Intervention unterzogen. Der Großteil der Patientinnen erhielt eine Beckenbestrahlung, welche die inguinalen Lymphbahnen einschloss (mittlere Dosis: 50 Gy). 26 Patientinnen erhielten zusätzlich eine intravaginale Brachytherapie. Ergebnisse: Insgesamt erreichten 21 Patientinnen (51,2%) eine komplette Remission, 17 Patientinnen (41,5%) wiesen eine partielle Remission auf, und drei Patientinnen (7,3%) zeigten keine Veränderung bzw. ein Fortschreiten der Erkrankung. Das Gesamtüberleben für alle Patientinnen lag im Median bei 41,3 Monaten. Die 1-Jahres-Überlebenswahrscheinlichkeit betrug 85,4%, die 5-Jahres-Überlebenswahrscheinlichkeit 40,6% und die 10-Jahres-Überlebenswahrscheinlichkeit 27,2%. Die univariate Analyse zeigte einen Überlebensvo...

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Section: Discussionsupporting

confidence: 78%

Long-Term Results of Radiotherapy in Primary Carcinoma of the Vagina

et al. 2009

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“…Carcinoma of vagina mainly occurs in individuals older than 60 years old [71,[204][205][206]. Our study showed a clear positive correlation between age and DSBs detected in vaginal cells of the studied population.…”

Section: Cigarette Smoking and Hpv Infection Act Independently In Vagsupporting

confidence: 51%

“…Additionally, age-related differences have been reported among individuals diagnosed with cervical cancers compared to those with vaginal cancers [71]. Carcinoma of vagina mainly occurs in elderly women (~ 60 years) [71,[204][205][206]. This finding signifies the age-associated alterations in DNA structure, such as double-strand breaks [132] that may, in turn, attribute to genetic instability and ultimately vaginal carcinogenesis.…”

Section: E Discussionmentioning

confidence: 85%

Cigarette smoke, DNA damage and repair in human cervical and vaginal cells in vitro and ex vivo.

Moktar¹

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DEDICATION This dissertation is dedicated to my parents, Ahmad and AshTabatabaie, for instilling in me the importance and power of hard work and higher education, for shaping me into the person I am today, and for all their love and kindness.I would also like to dedicate this dissertation to my wonderful husband, Reza Moktar, for giving me the best chance for educational growth. With his love, support and patience he has opened my eyes to the world and allowed me to follow my dreams.Moreover, this dissertation is dedicated to our amazing and lovely daughter, Melody A. Moktar, who gave me a new perspective on life.hope I can make up for all the time that we spent apart. Vlll

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“…Primary tumors in the lower third of the vagina often drain to the femoral and inguinal lymph nodes. 124 Isolated studies using FDG-PET/CT in vaginal cancer are limited. Lamoreaux et al 125 compared CT alone with FDG-PET/CT in 23 patients.…”

Section: Vaginal Carcinomamentioning

confidence: 99%