Thirty days complication rate following surgery performed for deep‐brain‐stimulation

Abstract

Serious adverse events (SAEs) during the first 30 postoperative days after stereotactic surgery for Deep-Brain-Stimulation performed in 1,183 patients were retrospectively collected from five German stereotactic centers. The mortality rate was 0.4% and causes for death were pneumonia, pulmonary embolism, hepatopathy, and a case of complicated multiple sclerosis. The permanent surgical morbidity rate was 1%. The most frequently observed SAEs were intracranial hemorrhage (2.2%) and pneumonia (0.6%). Skin infection occurred in 5 of 1,183 patients (0.4%). Surgical complications caused secondary AEs (e.g. pneumonia) preferentially in older patients and in patients treated for Parkinson's disease (PD). Complication rates did not differ among the five centers.

Complications of Subthalamic Nucleus Stimulation in Parkinson's Disease

“…The mortality rate during the first 30 postoperative days after stereotactic surgery was 0.4%, and the permanent surgical morbidity rate was 1%, mainly caused by ICH (2.2%) in a large series (1183 patients). 28) Recent analysis of adverse events in published data revealed 2.0% symptomatic ICH and 2.0% infection in 928 STN-DBS cases. 27) Permanent stimulation or disease progression-related adverse events included dysarthria in 12.8%, ALO in 11.3%, cognitive decline in 5.8%, disabling dyskinesia in 4.7%, and depression in 4.3% of 256 STN-DBS cases.…”

“…4,7,10,14,17,18,[20][21][22][23][24]27,28) Most are mild and transient, but some serious morbidity also occurs. The mortality rate during the first 30 postoperative days after stereotactic surgery was 0.4%, and the permanent surgical morbidity rate was 1%, mainly caused by ICH (2.2%) in a large series (1183 patients).…”

“…8) DBS is considered to cause less morbidity than ablative procedures, but is associated with a significant incidence of adverse effects. 4,7,10,14,17,18,[20][21][22][23][24]27,28) In this study, we retrospectively analyzed DBSrelated complications in a consecutive series of 180 patients who underwent bilateral STN-DBS to consider preventive methods.…”

Advanced research on deep brain stimulation in treating mental disorders (Review)

“…Physical side effects include intracranial hemorrhage, which has a prevalence of 0.4-1.3% and irreversible brain damage, which has a prevalence of 0.8% (89). Furthermore, studies in patients who have undergone DBS have found that the prevalence of infection, epileptic seizure and cutaneous complications are 0.7, 1.5 and 25%, respectively (87,90,91).…”

Key considerations in designing a somatosensory neuroprosthesis

“…Indeed, thalamic DBS is commonly used to treat multiple diseases involving movement disorders and/or chronic pain. DBS electrodes have been shown to be safe and stable (Haberler et al, 2000;Voges et al, 2007). Finally, thalamic stimulation has been shown to evoke localized tactile sensations (Heming et al, 2010;Weiss et al, 2009).…”