Advanced research on deep brain stimulation in treating mental disorders (Review)

Wang, Dong‐Xin; Liu, Xuejun; Zhou, Bin; Kuang, Weiping; Guo, Tong

doi:10.3892/etm.2017.5366

Cited by 3 publications

(5 citation statements)

References 102 publications

(109 reference statements)

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“…First, we compared preoperative BMI to postoperative BMI values obtained at the monthly assessments, finding no significant increase in body mass in the overall sample. This lack of a significant difference in BMI could be attributed to the particular characteristics of our patient sample versus other studies that did find significant differences in BMI after DBS [ 29 , 30 , 32 , 34 ]. First, unlike many of those studies, we included treatment-resistant, chronic patients.…”

Section: Discussioncontrasting

confidence: 65%

“…Third, we used different stimulation targets (SCC or NAcc) depending on the comorbid psychopathology (affective predominance or anxious predominance, respectively). Previous studies [ 29 , 31 , 32 , 33 , 34 ] have also evaluated DBS for AN, using the same targets (SCC and NAcc). However, to our knowledge, none of those studies considered comorbidities or the type of AN when selecting the DBS target.…”

Section: Discussionmentioning

confidence: 99%

“…Although the precise mechanism of action of DBS remains unclear, several models and hypotheses have been proposed. Electrophysiological studies suggest that the effect of DBS depends on the type of stimulated brain tissue (e.g., grey or white matter) and on the type of fibers involved in the stimulation [ 13 , 28 , 29 ]. In addition, DBS is believed to alter neuronal discharge patterns in the target area (jamming effect).…”

Section: Introductionmentioning

confidence: 99%

“…These different mechanisms may thus combine both inhibitory and excitatory processes, which could act simultaneously. Even though DBS is applied locally to a specific brain area, both focal and distal effects have been reported [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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A Randomized Trial of Deep Brain Stimulation to the Subcallosal Cingulate and Nucleus Accumbens in Patients with Treatment-Refractory, Chronic, and Severe Anorexia Nervosa: Initial Results at 6 Months of Follow Up

Martínez

Justicia

Salgado

et al. 2020

JCM

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Background: The main objective of this study was to assess the safety and efficacy of deep brain stimulation (DBS) in patients with severe anorexia nervosa (AN). Methods: Eight participants received active DBS to the subcallosal cingulate (SCC) or nucleus accumbens (NAcc) depending on comorbidities (affective or anxiety disorders, respectively) and type of AN. The primary outcome measure was body mass index (BMI). Results: Overall, we found no significant difference (p = 0.84) between mean preoperative and postoperative (month 6) BMI. A BMI reference value (BMI-RV) was calculated. In patients that received preoperative inpatient care to raise the BMI, the BMI-RV was defined as the mean BMI value in the 12 months prior to surgery. In patients that did not require inpatient care, the BMI-RV was defined as the mean BMI in the 3-month period before surgery. This value was compared to the postoperative BMI (month 6), revealing a significant increase (p = 0.02). After 6 months of DBS, five participants showed an increase of ≥10% in the BMI-RV. Quality of life was improved (p = 0.03). Three cases presented cutaneous complications. Conclusion: DBS may be effective for some patients with severe AN. Cutaneous complications were observed. Longer term data are needed.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Randomized Trial of Deep Brain Stimulation to the Subcallosal Cingulate and Nucleus Accumbens in Patients with Treatment-Refractory, Chronic, and Severe Anorexia Nervosa: Initial Results at 6 Months of Follow Up

Martínez

Justicia

Salgado

et al. 2020

JCM

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“…Penggunaan deep brain stimulation. 24 C. Vagus nerve stimulator ( NS) VNS dipertimbangkan sebagai terapi paliatif pada pasien resisten obat antiepilepsi, tanpa indikasi pembedahan reseksi otak; teknik ini sudah digunakan sebagai terapi epilepsi sejak tahun 1994 di Eropa. 10 Mekanisme kerja VNS sebagai antiepilepsi masih belum jelas.…”

Section: A Diet Ketogenikunclassified

Tatalaksana Epilepsi Refrakter

Mahendrakrisna¹,

Pinzon

2020

CDK

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<p>Epilepsi refrakter atau resisten obat didefinisikan sebagai kegagalan respon terhadap dua obat anti epilepsi sesuai jadual, dosis, dan rute pemberian, baik monoterapi maupun kombinasi, untuk tercapainya bebas serangan. Serangan epilepsi yang tidak terkontrol atau resisten obat umumnya berkaitan dengan prognosis buruk, dan mengganggu kualitas hidup. Beberapa pilihan terapi kasus epilepsi refrakter yaitu Diet Ketogenik, Deep Brain Stimulator (DBS), Vagal Nerve Stimulator (VNS), Transcranial Magnetic Stimulation (TMS), Responsive Cortical Neuro-Stimulator (RNS), dan Pembedahan. Terapi lini pertama adalah pembedahan reseksi,</p><p>Refractory epilepsy is defined as an epilepsy unresponsive to two or more anti epileptic drugs with proper schedule and doses, on monotherapy and combined therapy, to achieve seizures freedom. Refractory epilepsy was associated with poor prognostic and decreased quality of life. Several alternatives for refractory epilepsy are ketogenic diet, Deep Brain Stimulator (DBS), Vagal Nerve Stimulator (VNS), Transcranial Magnetic Stimulation (TMS), Responsive Cortical Neuro-Stimulator (RNS), and surgery. The first line therapy for refractory epilepsy is resection surgery.</p>

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Возможности Психохирургии И Инвазивной Нейромодуляции В Лечении Терапевтически Резистентных Психических Расстройств. Феномен Ренессанса?

Иванов¹,

Stanovaya²,

Катышев³

et al. 2021

Психиатрия

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Применение методов хирургического лечения пациентов с психическими расстройствами, как известно, имеет многовековую историю. Эта область медицины, получившая название психохирургия, включает оперативные воздействия в тех случаях, когда методы фармакологического и нефармакологического лечения оказываются неэффективными, т. е. так называемая терапия отчаяния. В обзоре, который является результатом совместного труда психиатров и нейрохирургов, описываются исторические этапы становления психохирургии, основные показания и противопоказания к хирургическому лечению, эффективность и возможные осложнения психохирургических вмешательств. Значительное внимание уделяется рассмотрению таких методов лечения, как цингулотомия, капсулотомия, субкаудатная трактотомия, лимбическая лейкотомия, глубокая стимуляция мозга (DBS) и стимуляция блуждающего нерва (VNS).Авторы, понимая неоднозначность содержащихся в обзоре результатов исследований и дискуссионных приводимых суждений, вместе с тем считают целесообразным рассмотреть диапазон возможностей применения современных методов психохирургии в лечении ряда состояний, имеющих проявления резистентности к иным видам лечения. Вместе с тем отмеченная дискуссионная форма делает более чем обоснованным, на наш взгляд, предложение о последующей полемике на страницах журнала как о показаниях для психохирургии и ее последствиях, так и о самой целесообразности применения хирургических вмешательств в психиатрической практике. The use of methods of surgical treatment of patients with mental disorders is known to have a long history. This area of medicine, called psychosurgery, includes the methods of surgical intervention used in cases where other methods of pharmacological and non-pharmacological treatment are ineffective, i.e. the so-called "despair therapy". The review, which is the result of joint work of psychiatrists and neurosurgeons, describes the historical stages of psychosurgery, the main indications and contraindications to surgical treatment, the effectiveness and possible complications of psychosurgical interventions. Significant attention is paid to the consideration of such treatment methods as cingulotomy, capsulotomy, subcaudate tractotomy, limbic leucotomy, deep brain stimulation (DBS), and vagus nerve stimulation (VNS).The authors, understanding the ambiguity of the results of certain studies and the controversial judgments presented in the review, however, consider it appropriate to discuss the possibility of using modern methods of psychosurgery in the treatment of a number of conditions that have manifestations of resistance to other types of treatment. However, the above discussion form makes it more than reasonable in our opinion to suggest a subsequent polemic on the pages of the journal about the possibilities of psychosurgery and about the very feasibility of its application in psychiatric practice.

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Advanced research on deep brain stimulation in treating mental disorders (Review)

Abstract: Abstract. Deep brain stimulation is a method that involves using an electric stimulus on a specific target in the brain with stereotaxis.

Cited by 3 publications

References 102 publications

A Randomized Trial of Deep Brain Stimulation to the Subcallosal Cingulate and Nucleus Accumbens in Patients with Treatment-Refractory, Chronic, and Severe Anorexia Nervosa: Initial Results at 6 Months of Follow Up

A Randomized Trial of Deep Brain Stimulation to the Subcallosal Cingulate and Nucleus Accumbens in Patients with Treatment-Refractory, Chronic, and Severe Anorexia Nervosa: Initial Results at 6 Months of Follow Up

Tatalaksana Epilepsi Refrakter

Возможности Психохирургии И Инвазивной Нейромодуляции В Лечении Терапевтически Резистентных Психических Расстройств. Феномен Ренессанса?

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