Thirst deficits in aged rats are reversed by dietary omega-3 fatty acid supplementation

Begg, Denovan P.; Sinclair, Andrew J.; Weisinger, R. S.

doi:10.1016/j.neurobiolaging.2011.12.001

Cited by 11 publications

(2 citation statements)

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“…Further studies reported that there was an interaction between ω-3 deficiency and the level of dietary protein on hypertension [34], with mechanistic investigations leading to the conclusion that the hypertension resulting from ω-3 deficiency was mediated by the central adrenergic system [35]. During the course of working with Richard Weisinger and Denovan Begg, aged ω-3 deficient rats were found to have significant alterations in brain arachidonic acid (ω-6 fatty acid) metabolism, including significantly elevated hypothalamic PGE(2) [36]. These novel observations were followed up by testing the behavioural effects of refeeding ω- animals with either ω-3 FA or a COX inhibitor.…”

Section: Veterinary Biochemistry Indigenous Foods and Lean Red Meat S...mentioning

confidence: 99%

Navigating my career in lipid research

Sinclair

2024

Eur J Clin Nutr

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THE STARTMy journey really didn't start until I enrolled in a PhD in the Biochemistry Department at the University of Melbourne in 1965, although little did I know at the time that I would end up having a 55+ year career in nutrition. I chose to enrol for a PhD on essential fatty acids (EFA) although offerings in the Departments of Microbiology or Botany were equally of interest. One of life's hindsight moments: why didn't I investigate the merits of the projects in all three disciplines? My interest in biochemical metabolism was stimulated by the fascinating biochemistry lectures in the 3rd and 4th year of an Agricultural Science degree at the same university; this 4-year course covered a wide range of topics with the final year of eight subjects offering a wide range of career options for the graduates. My family connection to agriculture was through both my grandfathers (maternal grandfather owned an orange farm and my paternal grandfather was into agricultural education), though these links were not the reason I chose Ag Sciencerather it was to do a course with lots of options after graduation. A highlight of my PhD time, aside from forming lifelong friendships with other graduate students, was being involved in a multidisciplinary investigation of the first case of EFA deficiency in an adult human [1].My story is largely about multi-disciplinary collaborations and mentoring, a long, but extremely rewarding journey, having met so many talented, generous and mostly compatible people, many of whom are still friends. Speaking of friends, I must mention Robert (Bob) Gibson, my best friend, whom I have known since 1976; we have researched in complimentary areas, and it has been such a pleasure to chat to him over the years about nutrition, lipids, football and many other matters. How lucky are we to have had this long connection. Together we ran two very successful international fatty acid congresses which drew many visitors to Adelaide in 1992 [2] and to Cairns in 2006 [3].I cannot pretend that what follows is a coherent pattern of research, apart from working mostly in the field of lipids, but rather it is a blend of goal-oriented research as well as a series of opportunistic endeavours often based on what funding opportunities were available.

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Section: Veterinary Biochemistry Indigenous Foods and Lean Red Meat S...mentioning

confidence: 99%

Navigating my career in lipid research

Sinclair

2024

Eur J Clin Nutr

Self Cite

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show abstract

“…Consistent with the potential for direct actions of n-3 PUFA in the H-P axis, studies in rodents show that dietary administration of n-3 PUFAs increases the levels of EPA and DHA in the hypothalamus and other brain regions. [26,34,[37][38][39][40][41][42][43] Given that we had very limited tissue from each animal, we were unable to assay for EPA and DHA levels in the pituitary and hypothalamus, although this is a future experimental goal. An additional limitation of this study was the lack of information regarding circulating hormone levels, which is also an important future objective.…”

Section: Epa and Dha Ethyl Esters Rescue Hf Diet-mediated Changes In ...mentioning

confidence: 99%