Third Millennium Assisted Reproductive Technologies: The Impact of Oocyte Vitrification

Boyer, Pierre; Rodrigues, Pedro; Tourame, P.; Silva, M.; Barata, Madalena; Perez-Alzaa, J.; Boyer, M.

doi:10.5772/38596

Cited by 4 publications

(3 citation statements)

References 44 publications

(32 reference statements)

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“…Furthermore, cumulative ongoing pregnancy rate achieved with oocyte vitrification was shown to be as good as pregnancy rate obtained without the use of oocyte vitrification [8]. These encouraging results show that oocyte vitrification procedure is the cutting-edge technique that will bring about a dramatic change in the field [9,10]. French teams were not allowed using oocyte vitrification for years as it was considered as a research on human embryo so far forbidden in France.…”

Section: Introductionmentioning

confidence: 87%

Oocyte vitrification: A local validation of the method

Boyer¹,

Montjean²,

Tourame³

et al. 2013

OJOG

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Is there a really need to validate oocyte vitrification technique in an ART laboratory before establishing it in daily practice? Validation of micromanipulationbased technique, in this case oocyte vitrification, is essential prior to enlarging its use to routine practice. Oocyte vitrification is a new worldwide used technique and legal recently in France. This micromanipulation needs to be performed by a skilled and experienced embryologist and requires an internal assessment in each ART unit before any wide use. We designed a prospective study, from September 2011 to July 2012, using sibling oocytes from women who recovered more than 12 Metaphase II oocytes. A part of freshly recovered oocytes underwent immediate ICSI while the remaining oocytes were vitrified. 87 couples undergoing ICSI were selected based on number of mature oocytes available on the recovery day after denudation. A part of fresh MII oocytes were microinjected and the others were vitrified using an open system (Cryotop ® ). The major criterion of interest was the number of embryo transferred/ number of Metaphase II ratio for after ICSI on fresh oocytes (42/211) versus vitrified/warmed oocytes (51/204) (p > 0.05). Secondary studied criteria were survival rate (80.5% ± 26.3%), fertilization rate (68.9 ± 33.5) and finally, cumulative pregnancy rate obtained in this study is 40.2%. One of the benefits of such practice is the limitation of embryo freezing. However, the study design delays oocytes warming cycles, due to pregnancies triggered by the transfer of fresh derived oocyte embryos and to the priority to transfer all the frozen embryos before starting oocytes warming. Moreover, no data is available about children' health. Oocyte vitrification represents not only a change in our daily practice to improve cumulative pregnancy rate but also a promising tool to develop egg banking and donation. Clinical Trials Registration number: 209 R02.

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Section: Introductionmentioning

confidence: 87%

Oocyte vitrification: A local validation of the method

Boyer¹,

Montjean²,

Tourame³

et al. 2013

OJOG

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“…Cette organisation privilé giant le dé placement des couples plutô t que celui des gamè tes favorise une diminution du risque de consanguinité . Les ovocytes des femmes jeunes, celles qui ont eu recours à l'AMP pour indication masculine, repré sente une source substantielle pour le don permettant probablement d'atteindre l'autosuffisance [7,8].…”

Section: Origine Des Ovocytesunclassified

La vitrification des ovocytes et les changements induits dans nos pratiques d’AMP

Boyer¹,

Tourame²,

Boyer³

2012

Gynécologie Obstétrique & Fertilité

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“…Today, this method which is based on a proven methodology, validated in Evidence Based Medicine, 2 fulfills the ethical imperatives of such a medical proposal, as early as 2013. 3 We take care of patients in an Oncological context but also of those who have benign pathologies. Among these situations, endometriosis is a disease with a high risk of premature ovarian failure and iterative surgery.…”

Section: Introductionmentioning

confidence: 99%

Non-cancer female fertility preservation: strategy for a birth

Boyer¹,

Siraudin²,

Boyer³

et al. 2018

OGIJ

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In recent years, the law n˚ 2011-814 of July 7, 2011 relating to the bioethics authorizes the ultra-rapid freezing of the oocytes offering to the centers of medical assistance with procreation a new tool at the service of the preservation of the female fertility. Although the medical proposal to resort to preservation has taken its place in cancerous pathologies, the same is not the case for other situations of risk of impaired fertility, whether medical or surgical. Endometriosis, which we know the impact on fertility, is a perfect example of the need to set up a treatment course with cryo-oocytes conservation for young patients before surgical management. We report the first birth after treatment for preservation of fertility in the context of severe hyperalgic endometriosis. The meeting between the MPA and the pelvic gynecological surgery is a step forward for these women. We will discuss the implementation of a protocol of care in the image of what exists on fertility.

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Third Millennium Assisted Reproductive Technologies: The Impact of Oocyte Vitrification

Cited by 4 publications

References 44 publications

Oocyte vitrification: A local validation of the method

Oocyte vitrification: A local validation of the method

La vitrification des ovocytes et les changements induits dans nos pratiques d’AMP

Non-cancer female fertility preservation: strategy for a birth

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