Thiosulfonates: The Prospective Substances against Fungal Infections

Abstract

The synthesis of new analogs of natural biologically active substances is a promising direction for the development of effective antifungal agents. Thiosulfonic acid esters (thiosulfonates) are the structural analogs of biocidal compounds from garlic, onion, cabbage, cauliflower, etc. More than 1000 thiosulfonates of various structures of the general formula RSO 2 SR' were synthesized at the Lviv Polytechnic National University, where their physicochemical properties were characterized. A high antifungal activity of the obtained substances was established in relation to the representatives of fungi of different genera. The thiosulfonates are perspective as basis for the development of effective antifungal means for the modern pharmaceutical, food industry, for the protection of various materials and agricultural products. To increase their effectiveness, antimicrobial compositions based on thiosulfonates and surfactants of microbial origin (biosurfactants) in the form of stable suspensions were developed and studied. It has been established that the use of biosurfactants in the compositions allows the enhancement of the antifungal activity of thiosulfonates and reduction of their active concentration. The possible mechanisms of the joint action of thiosulfonates and biosurfactants on fungal pathogens are proposed.

Effects of ethylthiosulfanylate and chromium (VI) on the state of pro/antioxidant system in rat liver

“…It is known that synthetic thiosulfonates have a wider range of biological activity and are more stable than their natural analogs. Also thiosulfonates have a low level of toxicity for animal organism [8,9]. The literature date report that natural organosulfur analogs of thiosulfonates exhibit a wide range of biological activity including effective antioxidant and detoxifying properties against heavy metals toxicity [10,11].…”

“…The literature date report that natural organosulfur analogs of thiosulfonates exhibit a wide range of biological activity including effective antioxidant and detoxifying properties against heavy metals toxicity [10,11]. In recent years is actively conducted investigations of the properties of thiosulfonates in different scientific directions [9]. Previous studies have shown that ethylthiosulfanylate is involved in regulation of the activity of the lipid metabolism enzymes and performs the redistribution of lipid classes and a decrease in mono-, di-, triglycerides and free fatty acids in the rat liver [8].…”

“…Administration of ethylthio sulfanylate induces the increase of total protein and albumin content in rat blood plasma [12]. Also, ethylthiosulfanylate is an effective agent against fungal infections and has antimicrobial effect [9].…”

New Technologies of Effective Protection of Textiles Against Microbiological Damage

“…І одним із нових перспективних екологічних розроблень в цьому напрямі сьогодні можна вважати біоцидні препарати тіосульфонатної структури, синтезовані на кафедрі технології біологічно активних сполук, фармації та біотехнології Національного університету «Львівська політехніка». Дані біоцидні препарати ефективно використовуються як біоциди для захисту лакофарбових товарів, добавки для захисту від біопошкоджень мастильно-охолоджувальних рідин, біоцидна складова антикорозійної композиції для трубопроводів систем оборотного водопостачання, нафтопродуктів, будівельних матеріялів і конструкцій, альгіциди для захисту поверхонь, пакувальних матеріялів, для стерилізації культуральної рідини у біотехнологічних виробництвах тощо [21][22][23][24].…”

S-Methyl-(2-Methoxycarbonylamino-Benzimidazole-5) Thiosulfonate as a Potential Antiparasitic Agent—Its Action on the Development of Ascaris suum Eggs In Vitro

“…These compounds are unstable during storage [ 19 ]. Structural analogs of allicin are thiosulfonates RS(O) 2 SR’, which are stable biologically active compounds with a broad spectrum of action [ 20 , 21 ]. Synthetic esters of thiosuloacids (ETS) are highly reactive compounds that interact mainly by nucleophilic substitution reactions occurring with the breaking of an S-S-bond due to the redistribution of electron density in the thiosulfone group that determines the direction of nucleophile attack.…”