Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke

Qi, Ai-qin; Li, Yan; Liu, Qiang; Si, Junzeng; Tang, Xiaomei; Zhang, Zhiqiang; Qi, Qinde; Chen, Weibi

doi:10.1016/j.freeradbiomed.2014.12.021

Cited by 34 publications

(26 citation statements)

References 39 publications

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“…Functional outcome was assessed by the modified Rankin Scale (mRS) [23] blinded to serum biomarkers. A favorable functional outcome was defined as a mRS of 0-2 points, whereas an unfavorable outcome was defined as a mRS of >2 points [24]. Secondary end-points were all-cause mortality within 3 months.…”

Section: End Points and Follow-upmentioning

confidence: 99%

U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke

Yang

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: We sought to assess a consecutive number of patients with first-ever acute ischemic stroke (AIS), the clinical relevance in regard to functional outcome of the serum uric acid (SUA) measured at admission. Methods: In 2 prospective centers for observational study, serum concentrations of SUA were measured on admission in the serum of 710 consecutive patients with AIS. SUA concentrations were determined by high-performance liquid chromatography. SUA, NIH stroke scale (NIHSS), and conventional risk factors were evaluated to determine their value to predict functional outcome within 3 months. Results: During the follow-up, an unfavorable functional outcome (defined as a mRS score > 2) was found in 219 (30.8%) patients. The unfavorable functional outcome distribution across the SUA quartiles ranged between 12.4% (third quartile) and 50.6% (first quartile). After adjusting for all other significant outcome predictors, SUA concentration remained an independent unfavorable outcome predictor with an adjusted OR of 0.996 (95% CI, 0.993-0.998; P< 0.001). Conclusions: The data show that the U-shaped nature of the exposure-risk relationship was more prominent when the data were assessed in deciles (based on the SUA values). This model predicted the lowest relative risk of unfavorable outcome in the 67th percentile (corresponding to 309 µmol/L). SUA was significantly associated with the risk of poor functional outcomes in Chinese patients with stroke.

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Section: End Points and Follow-upmentioning

confidence: 99%

U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke

Yang

Zhang

et al. 2018

Cell Physiol Biochem

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“…skeletal muscle [116]). As an exception, redox enzyme content in plasma may be useful biomarkers in health and disease [117], [118], [119]. For example, elevated serum PRDX4 content is regarded as a novel stroke risk factor [118].…”

Section: Redox Enzymes In Plasmamentioning

confidence: 99%

“…As an exception, redox enzyme content in plasma may be useful biomarkers in health and disease [117], [118], [119]. For example, elevated serum PRDX4 content is regarded as a novel stroke risk factor [118]. Redox enzyme content can be easily assessed using quantitative immunoblotting [120].…”

Section: Redox Enzymes In Plasmamentioning

confidence: 99%

Exercise redox biochemistry: Conceptual, methodological and technical recommendations

Cobley

Bailey

et al. 2017

Redox Biology

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Exercise redox biochemistry is of considerable interest owing to its translational value in health and disease. However, unaddressed conceptual, methodological and technical issues complicate attempts to unravel how exercise alters redox homeostasis in health and disease. Conceptual issues relate to misunderstandings that arise when the chemical heterogeneity of redox biology is disregarded: which often complicates attempts to use redox-active compounds and assess redox signalling. Further, that oxidised macromolecule adduct levels reflect formation and repair is seldom considered. Methodological and technical issues relate to the use of out-dated assays and/or inappropriate sample preparation techniques that confound biochemical redox analysis. After considering each of the aforementioned issues, we outline how each issue can be resolved and provide a unifying set of recommendations. We specifically recommend that investigators: consider chemical heterogeneity, use redox-active compounds judiciously, abandon flawed assays, carefully prepare samples and assay buffers, consider repair/metabolism, use multiple biomarkers to assess oxidative damage and redox signalling.

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“…Mortality after 1 year ranges between 21% and 27%; 15% to 30% of survivors are permanently disabled [2]. An early risk assessment with estimate of the severity of disease and prognosis is pivotal for optimized care and allocation of healthcare resources to improve outcome [3].…”

Section: Introductionmentioning

confidence: 99%

Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke

Liu

2015

Journal of the Neurological Sciences

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Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke

Cited by 34 publications

References 39 publications

U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke

U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in Ischemic Stroke

Exercise redox biochemistry: Conceptual, methodological and technical recommendations

Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke

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