Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke

Li, Youmei; Liu, Xueyuan

doi:10.1016/j.jns.2015.03.032

Cited by 38 publications

(29 citation statements)

References 26 publications

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“…Higher mean peripheral leukocyte counts on admission [14], higher mean hs-CRP levels on admission [16], acute infection preceding ischemic stroke and post-stroke infections (e.g., stroke-associated pneumonia) [13] are well-known risk factors for poor outcomes, and these were also confirmed as risk factors in our study. Admission hyperglycemia is a well-known risk factor for poor outcomes in both human and animal studies [13,18], and this association was also seen in our study. The presence of aphasia predicted unfavorable outcomes in patients with ischemic stroke in our study as well as others [17].…”

Section: Discussionsupporting

confidence: 85%

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Predictors of poor outcomes in First-Event Ischemic Stroke as assessed by Magnetic Resonance Imaging

Jia¹,

Huang²,

Zou³

et al. 2016

CIM

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Purpose: Stroke is the third most common cause of mortality worldwide and is a major cause of permanent disability. The purposed of the study was to better understand the risk factors for poor outcomes following ischemic stroke requiring treatment. Methods:Three hundred seventy patients with first-event ischemic stroke were enrolled. Good outcomes was defined as a using the Modified Rankin Scale (MRS) score ≤3 without any cardiovascular event, while poor outcomes were any of the following end points: MRS >3 at 3 months, recurrent stroke or death. Prognostic variables for poor outcomes were analyzed based on a stepwise logistic regression model.Results: Seventy-eight patients had poor outcomes (21%, 78/370), assessed at a minimum of six-month follow-up. Higher mean National Institutes of Health Stroke Scale (NIHSS) scores at presentation, presence of early neurologic deterioration (END) and higher mean high-sensitivity C-reactive protein (hs-CRP) levels were associated with poor outcomes at discharge. Furthermore, both NIHSS at presentation and the presence of END were associated with poor outcomes, assessed at a minimum of six-month follow-up.Conclusion: A higher mean initial NIHSS score implies not only severe neurologic deficits but also an increased risk of poor outcomes. Since END following ischemic stroke is frequently associated with poor outcomes, more attention should be directed to providing adequate treatment to patients in the acute stage, especially for high risk patients.

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Section: Discussionsupporting

confidence: 85%

“…In addition to NIHSS scores, there are several clinical risk factors that contribute to poor functional outcomes after ischemic stroke [8,[13][14][15][16][17][18][19]. The majority of the damage following acute ischemic stroke does not occur immediately, but rather develops gradually over the course of the following hours [20].…”

Section: Discussionmentioning

confidence: 99%

Predictors of poor outcomes in First-Event Ischemic Stroke as assessed by Magnetic Resonance Imaging

Jia¹,

Huang²,

Zou³

et al. 2016

CIM

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“…Furthermore, specific challenges regarding biomarkers of central nervous tissue include the penetration of BBB and the lack of correlation between functional symptoms and volume (as opposed to location) of injured tissue. According to pathophysiological processes underlying IS, potential inflammatory biomarkers may be classified as released by: (i) astroglial activation and neuronal injury (Table 1) [146,147,148,149,150,151,152,153,154,155,156,157]; (ii) systemic inflammatory response (Table 2) [158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179]; (iii) dysfunctional endothelium (Table 3) [180,181,182,183,184,185,186] (Figure 4). …”

Section: Inflammatory Mediators As Potential Diagnostic or Prognosmentioning

confidence: 99%

“…Early increase of CRP occurs in IS and in many other inflammatory conditions as well, thus reflecting the low specificity of this biomarker. Furthermore, various studies suggested a potential role of CRP as predictor of worse neurological outcome, but this evidence remains controversial [158,159,160,161,162,163,164,167,168,195]. In this regard, a recent systematic review from 46 studies recognized CRP as independent predictor of long-term functional outcome in only 13 studies [196].…”

Section: Inflammatory Mediators As Potential Diagnostic or Prognosmentioning

confidence: 99%

Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke

Bonaventura

Liberale

Vecchiè

et al. 2016

IJMS

133

114

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After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly induce both beneficial and detrimental effects. In this narrative review, we updated evidence on the inflammatory pathways and mediators that are investigated as promising therapeutic targets. We searched for papers on PubMed and MEDLINE up to August 2016. The terms searched alone or in combination were: ischemic stroke, inflammation, oxidative stress, ischemia reperfusion, innate immunity, adaptive immunity, autoimmunity. Inflammation in AIS is characterized by a storm of cytokines, chemokines, and Damage-Associated Molecular Patterns (DAMPs) released by several cells contributing to exacerbate the tissue injury both in the acute and reparative phases. Interestingly, many biomarkers have been studied, but none of these reflected the complexity of systemic immune response. Reperfusion therapies showed a good efficacy in the recovery after an AIS. New therapies appear promising both in pre-clinical and clinical studies, but still need more detailed studies to be translated in the ordinary clinical practice. In spite of clinical progresses, no beneficial long-term interventions targeting inflammation are currently available. Our knowledge about cells, biomarkers, and inflammatory markers is growing and is hoped to better evaluate the impact of new treatments, such as monoclonal antibodies and cell-based therapies.

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“…9 Moreover, PCT and hs-CRP are found as independent predictors of long-term mortality in patients with acute ischemic stroke and acute heart failure. 10,11 The rationale of this study is the changes in the PCT levels usually associated with changes in hs-CRP of whatever the pathological condition. Therefore, this study aimed to assess the simultaneous changes in the PCT and hs-CRP in DFS complicated type 1 and 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Measurements of serum high sensitivity-C reactive protein, and procalcitonin levels in type1 and 2 Diabetes complicated with diabetic foot syndrome

Al-Nimer

Dezayee

2017

Zanco J Med Sci

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Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke

Cited by 38 publications

References 26 publications

Predictors of poor outcomes in First-Event Ischemic Stroke as assessed by Magnetic Resonance Imaging

Predictors of poor outcomes in First-Event Ischemic Stroke as assessed by Magnetic Resonance Imaging

Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke

Measurements of serum high sensitivity-C reactive protein, and procalcitonin levels in type1 and 2 Diabetes complicated with diabetic foot syndrome

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