Abstract:Background:
Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme that catalyzes
thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine. There is a correlation
between thiopurine drug metabolism, response, and toxicity and genetic polymorphism of TPMT.
The aim of this study is to assess TPMT genetic polymorphisms activity and metabolic products of
AZA in patients with IBD.
Methods:
Blood samples were obtained from 50 IBD unrelated patients from a private laboratory. We
used polyme… Show more
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