Thionation of Essential Oils from Algerian Artemisia Herba-alba L. and Ruta Montana L.: Impact on their Antimicrobial and Insecticidal Activities

Fekhar, Nassiba; Boutoumi, Hocine; Krea, Mohamed; Moulay, Saâd; Drioueche, Asma; Benmaamar, Zoubir

doi:10.19261/cjm.2017.410

Cited by 10 publications

(16 citation statements)

References 19 publications

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“…Other known compounds were first tentatively identified through MS library matching technique (Table 1) and then after the isolation of constituents the structures were confirmed by comparison of the spectral data ( 1 HNMR, 13 CNMR and MS) with that reported in literature. Thus compound 1 was identified as artemisinin, [25] compound 2 as deoxy artemisinin25, compound 3 as gorgonolide, [6] compound 4 as 1‐β, 10‐α‐dihydroxy‐1,10 deoxygorgonolide, [6] compound 5 a as yangambin and 5 b as epi‐yangambin, [26] compound 6 as casticin also named as vitexicarpin, [27] compound 7 as 7,22‐ergostanediene‐3‐ol, [23] compound 8 as undecanol, [28] compound 9 as artabsinolide diepoxide, [29] compound 11 as campsterol, [30] compound 12 as stigmasterol, [30] compound 13 as artabsinolide A and compound 14 as artabsinolide C [29] . All the constituents were isolated using repeated normal phase column chromatography with varying polarity of mobile phase.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Identification of Cytotoxic and Antimalarial Constituents from Artemisia moorcroftiana

et al. 2021

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LC‐MS guided technique was applied for the detection and target separation of constituents of Artemisia moorcroftiana. Artemisinin together with fourteen other natural products viz; deoxyartemisinin, gorgonolide, 1‐β,10‐α‐dihydroxy‐1,10‐deoxygorgonolide, yangambin, epi‐yangambin, casticin, ergostanediene‐3‐ol, undecanol, artabsinolide diepoxide, campsterol, stigmasterol, artabsinolide A, artabsinolide C and 8,11‐diethylpentadec‐14‐en‐2‐one were isolated from the aerial parts of Artemisia moorcroftiana Wall. The isolated molecules were subjected to MTT cytotoxicity screening against a panel of four different human cancer cell lines to check their cytotoxic potential. Casticin was found as the most potent cytotoxic isolate. In addition the phytochemical investigation has resulted into the isolation of known antimalarial constituents like artemisinin, casticin, gorgonolide and deoxygorgonolide which has confirmed the folklure claims associated with Artemisia moorcroftiana wherein it is reported to be used as an effective remedy for the treatment of malaria.

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Section: Resultsmentioning

confidence: 99%

Isolation and Identification of Cytotoxic and Antimalarial Constituents from Artemisia moorcroftiana

et al. 2021

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“…Pneumonie , Pseudomonas fluorescence , Pseudomonas putida , Shigella sp., Staphylococcus epidermidis , Streptococcus agalactiae , and Streptococcus groupe. In another study, the essential oil of the aerial parts was found to be inactive against Escherichia coli but showed significant activity against Staphylococcus aureus with a zone of inhibition of 18 mm [ 70 ].…”

Section: Bioactivitiesmentioning

confidence: 99%

“…The major antifungal activity of the essential oil of the aerial part of R. montana was against Aspergillus , Alternaria , and Candida species [ 18 , 67 , 70 , 71 , 72 , 73 , 84 ]. This essential oil was also found to be active against Saccharomyces cerevisiae (12–15 mm) [ 67 ]), Cryptococcus neoformans (20 mm), Fusarium sp.…”

Section: Bioactivitiesmentioning

confidence: 99%

“…This oil was also found to be effective in killing mosquitoes Culex pipiens with 99% insecticidal effect at 0.6% essential oil concentration after 30 min. The impact of thionation of the essential oil of R. montana on insecticidal activity was explored by Fekhar et al [ 70 ] using the fumigation toxicity assay employing Sitophilus oryzae adults. The non-thionated essential oil of R. montana could kill 13% of insects within 24 h of exposure, and thionation of the essential oil apparently resulted in an increase in insecticidal activity.…”

Section: Bioactivitiesmentioning

confidence: 99%

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Ruta Essential Oils: Composition and Bioactivities

et al. 2021

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Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and for the treatment of lung diseases and microbial infections. The genus Ruta is rich in essential oils, which predominantly contain aliphatic ketones, e.g., 2-undecanone and 2-nonanone, but lack any significant amounts of terpenes. Three Ruta species, Ruta chalepensis L., Ruta graveolens L., and Ruta montana L., have been extensively studied for the composition of their essential oils and several bioactivities, revealing their potential medicinal and agrochemical applications. This review provides a systematic evaluation and critical appraisal of publications available in the literature on the composition and bioactivities of the essential oils obtained from Ruta species and includes a brief outlook of the potential applications of nanotechnology and chitosan-based products of Ruta essential oils.

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“…Previous studies have shown that R. montana can be considered as an important source of biologically interesting compounds, namely alkaloids, coumarins, flavonoids, tannins and essential oils (Kambouche et al, 2008;Boutoumi et al, 2009;Belkessame et al, 2011;Bouzidi et al, 2012; Synergistic effects of Ruta montana (Clus.) L. essential oil and antibiotics against some pathogenic bacteria et al, 2012; Hammiche et al, 2013;Ferhat et al, 2014;Khadhri et al, 2014;Hammami et al, 2015;Hazzit et al, 2015;Daoudi et al, 2016;Bennaoum et al, 2017;Fekhar et al, 2017;Benali et al, 2020;Drioiche et al, 2020;Mohammedi et al, 2020), with biological activities including antioxidant (Kambouche et al, 2008;Zellagui et al,2012;Benali et al, 2020;Mohammedi et al, 2020), antifungal (Hammami et al, 2015;Hazzit et al, 2015;Fekhar et al, 2017;Benali et al, 2020;Drioiche et al, 2020;Mohammedi et al, 2020), insecticidal and larvicidal (Boutoumi et al, 2009;Fekhar et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of Ruta montana (Clus.) L. essential oil and antibiotics against some pathogenic bacteria

Zeraib

Boudjedjou

Suici

et al. 2021

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Antibiotic resistance has been called one of the world’s most pressing public health threats. The combination of essential oils with conventional antibiotics is one of the emerging approaches that could help prevent this problem. In light of this, this study aimed to investigate the impact of combination of Ruta montana essential oil with conventional antibiotics on some pathogenic bacteria. The essential oil isolated by steam-hydrodistillation was first analyzed using GC-MS then tested alone and in combination with five recommended antibiotics against three bacterial strains by the agar disc diffusion and broth micro-dilution methods. Out of forty-nine peaks, thirty-eight components were identified representing 98.17% of the total oil composition. The major components were 2-Undecanone (63.39%), 2-Nonanone (5.65%), 2-Acetoxytetradecane (4.94%), 2-Decanone (4.47%) and 2-Dodecanone (3.35%). While R. montana essential oil showed only weak antibacterial activity compared to the antibiotics tested alone, unexpectedly, the combination of RM essential oil with antibiotics remarkably increased the antibacterial activity of the antibiotics through synergistic effects in up to 70% of cases. These results suggest that combining antibiotics with essential oils, even those with low antibacterial activity, may be effective in overcoming problems caused by increasing bacterial resistance.

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Thionation of Essential Oils from Algerian Artemisia Herba-alba L. and Ruta Montana L.: Impact on their Antimicrobial and Insecticidal Activities

Cited by 10 publications

References 19 publications

Isolation and Identification of Cytotoxic and Antimalarial Constituents from Artemisia moorcroftiana

Isolation and Identification of Cytotoxic and Antimalarial Constituents from Artemisia moorcroftiana

Ruta Essential Oils: Composition and Bioactivities

Synergistic effects of Ruta montana (Clus.) L. essential oil and antibiotics against some pathogenic bacteria

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