Thiomarinols B and C,New Antimicrobial Antibiotics Produced by a Marine Bacterium.

Shiozawa, Hideyuki; Kagasaki, Takeshi; Torikata, Akio; N, Tanaka; Fujimoto, Katsumi; Hata, Tadashi; Furukawa, Y.; Takahashi, Shuji

doi:10.7164/antibiotics.48.907

Cited by 69 publications

(43 citation statements)

References 4 publications

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“…(6), and dihydrophencomycin methyl ester from Streptomyces (36). In particular, some species of the genus Pseudoalteromonas (formerly Alteromonas) (11) produce both antibiotics and several bioactive substances (12,13,18,25,29,38,39,45). For example, Pseudoalteromonas rubra (12) and Pseudoalteromonas aurantia (13) have been reported to be antibiotic-producing bacteria.…”

mentioning

confidence: 99%

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 ^T , against Methicillin-Resistant Staphylococcus aureus

Isnansetyo

Kamei

2003

Antimicrob Agents Chemother

148

130

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We previously reported a new marine bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 T , which produced a bactericidal antibiotic against methicillin-resistant Staphylococcus aureus (MRSA). In the present study, we purified an anti-MRSA substance (MC21-A) from the methanol extract of the cells of P. phenolica O-BC30 T and analyzed its chemical structure. MC21-A was determined to be 3,3,5,5-tetrabromo-2,2-biphenyldiol by spectrometric analyses. Its anti-MRSA activity against 10 clinical isolates of MRSA was comparable to that of vancomycin (MC21-A MICs, 1 to 2 g/ml; vancomycin MICs, <0.25 to 2 g/ml). This substance was also high active against Enterococcus serolicida, Enterococcus faecium, and Enterococcus faecalis but was less active against Streptococcus spp. A time-kill study also demonstrated that MC21-A was bactericidal and that its killing rate was much higher than that of vancomycin. The postantibiotic effect (PAE) of MC21-A against a clinical MRSA isolate, strain E 31243, was also comparable to that of vancomycin (MC21-A PAEs, 1.46 to 1.65 h; vancomycin PAEs, 0.84 to 1.43 h). However, a lysis experiment demonstrated that this substance failed to lyse MRSA cells. This substance also did not lyse human erythrocytes. A SYTOX Green staining experiment implied that this substance permeabilized the cell membrane of MRSA as its mode of action. When its activities against a hypersensitive Escherichia coli mutant (KO 1489) and wild-type strains were tested, MC21-A exhibited higher levels of activity against the former. Furthermore, MC21-A was not cytotoxic to human normal fibroblast, rat pheochromocytoma, and Vero cells at concentrations up to 50 g/ml. These results suggest that MC21-A might be useful as a lead compound in the development of new types of anti-MRSA substances with modes of action different from those of vancomycin and teicoplanin.

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mentioning

confidence: 99%

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 ^T , against Methicillin-Resistant Staphylococcus aureus

Isnansetyo

Kamei

2003

Antimicrob Agents Chemother

148

130

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“…Thiomarinol B (161) showed [126] excellent in vitro antimicrobial activity against Gram-positive and Gramnegative bacteria ( Table 5). Thiomarinol C (162) was slightly less active than thiomarinol A. Thiomarinols D, E, F, and G (163-166) exhibited [126,127] antimicrobial activities against Gram-positive and Gram-negative bacteria. They were especially active against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus.…”

Section: Thiolanesmentioning

confidence: 99%

Pharmacologically Active Sulfur-Containing Compounds

Řezanka¹,

Sobotka²,

Spížek³

et al. 2006

AIAMC

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In addition to sulfur-containing compounds that form essential and indispensable constituents of all living cells, there is a plethora of less wide-spread sulfur-containing compounds with much less common and often unexpected properties, chemical structures and biological activities. Some of these compounds have long been known as efficient antibiotics. This review surveys these less known compounds with two and more sulfur atoms in their molecule. In particular, it deals with natural heterocyclic compounds isolated, e.g., from bacteria, fungi, lichens, plants, and animals but also from unusual and exotic sources such as sea invertebrates (coelenterates, sponges, tunicates, sea worms), etc. Compounds such as calicheamicins, thiazole-related compounds and epipolythiodioxopiperazines may serve as examples. Because of their vast variety, individual compounds are grouped according to their chemical structure (only compounds whose chemical structure has been identified are included). These compounds affect a huge array of organisms from microorganisms to man, and the pharmacological activities they exert range from antiviral, antibacterial, antifungal, insecticidal or antiprotozoan effects to regulation of gene expression, cytoskeleton disruption, immunomodulation, plant growth stimulation or inhibition, pro-or antioxidant action, effects on selected enzymes, receptors and signal transduction pathways, etc. The activities are however often known only sketchily, and this paucity of data, and the fact that the activities were tested on a diverse spectrum of test organisms, cell lines, etc., is of necessity reflected in our survey. Two seemingly trivial but important points deserve attention: (a) compounds with widely different structures and from widely different sources have often very similar pharmacological effects; (b) a slight modification in the molecule may bring vast changes in the biological effects of the compound, in terms of quality, quantity and targeting. The purpose of the review was to show both the unique and common features of these compounds and to point out their potential usefulness for mankind.

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“…Another marine bacterium, Alteromonas rava SANK 73390, has been shown to produce several sulphur-containing secondary metabolites, thiomarinols A-G (Figure 5a–g), with broad spectrum activity against Gram-positive and Gram-negative species [30–33]. The thiomarinols are especially active against Gram-positive bacteria and have pronounced activity against MRSA, in particular (MICs ≤ 0.01 μg/mL).…”

Section: Anti-methicillin-resistant Staphylococcus Aureus (Mrsa) Amentioning

confidence: 99%

Novel Anti-Infective Compounds from Marine Bacteria

et al. 2010

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As a result of the continuous evolution of microbial pathogens towards antibiotic-resistance, there have been demands for the development of new and effective antimicrobial compounds. Since the 1960s, the scientific literature has accumulated many publications about novel pharmaceutical compounds produced by a diverse range of marine bacteria. Indeed, marine micro-organisms continue to be a productive and successful focus for natural products research, with many newly isolated compounds possessing potentially valuable pharmacological activities. In this regard, the marine environment will undoubtedly prove to be an increasingly important source of novel antimicrobial metabolites, and selective or targeted approaches are already enabling the recovery of a significant number of antibiotic-producing micro-organisms. The aim of this review is to consider advances made in the discovery of new secondary metabolites derived from marine bacteria, and in particular those effective against the so called “superbugs”, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE), which are largely responsible for the increase in numbers of hospital acquired, i.e., nosocomial, infections.

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Thiomarinols B and C,New Antimicrobial Antibiotics Produced by a Marine Bacterium.

Cited by 69 publications

References 4 publications

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 ^T , against Methicillin-Resistant Staphylococcus aureus

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 ^T , against Methicillin-Resistant Staphylococcus aureus

Pharmacologically Active Sulfur-Containing Compounds

Novel Anti-Infective Compounds from Marine Bacteria

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Thiomarinols B and C,New Antimicrobial Antibiotics Produced by a Marine Bacterium.

Cited by 69 publications

References 4 publications

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 T , against Methicillin-Resistant Staphylococcus aureus

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 T , against Methicillin-Resistant Staphylococcus aureus

Pharmacologically Active Sulfur-Containing Compounds

Novel Anti-Infective Compounds from Marine Bacteria

Contact Info

Product

Resources

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MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 ^T , against Methicillin-Resistant Staphylococcus aureus

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30 ^T , against Methicillin-Resistant Staphylococcus aureus