Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

Puri, Vivek; Sharma, Ameya; Kumar, Pradeep; Singh, Inderbir

doi:10.3390/polym12081803

Cited by 59 publications

(37 citation statements)

References 111 publications

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“…Highly effective technique such as thiolation has been attempted to improve the mucoadhesive property of polymers since tethered thiols have the capacity to form disulfide bridge with the cysteine residues in mucin [ 47 , 48 ]. However, the in vivo mucosal retention of thiolated polymer is short lived because the disulfide bonds formed between thiol groups and mucin are reversible.…”

Section: Design and Formulation Of Buccal Drug-delivery Systemsmentioning

confidence: 99%

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

et al. 2021

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Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and various in vitro techniques frequently used for examining buccal drug-delivery systems. The role of mucoadhesive polymers, penetration enhancers, and enzyme inhibitors to circumvent the formulation challenges particularly due to salivary renovation cycle, masticatory effect, and limited absorption area are summarized. Biocompatible mucoadhesive films and patches are favored dosage forms for buccal administration because of flexibility, comfort, lightness, acceptability, capacity to withstand mechanical stress, and customized size. Preparation methods, scale-up process and manufacturing of buccal films are briefed. Ongoing and completed clinical trials of buccal film formulations designed for systemic delivery are tabulated. Polymeric or lipid nanocarriers incorporated in buccal film to resolve potential formulation and drug-delivery issues are reviewed. Vaccine-enabled buccal films have the potential ability to produce both antibodies mediated and cell mediated immunity. Advent of novel 3D printing technologies with built-in flexibility would allow multiple drug combinations as well as compartmentalization to separate incompatible drugs. Exploring new functional excipients with potential capacity for permeation enhancement of particularly large-molecular-weight hydrophilic drugs and unstable proteins, oligonucleotides are the need of the hour for rapid advancement in the exciting field of buccal drug delivery.

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Section: Design and Formulation Of Buccal Drug-delivery Systemsmentioning

confidence: 99%

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

et al. 2021

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“…Different studies have reported that chelating [ 29 ], permeation [ 30 ] and, especially, mucoadhesive [ 31 , 32 ] properties can be improved when sulphur-containing molecules are attached to the alginate backbone. In particular, the synthesis of thiol-containing biopolymers offers numerous attractive features for a variety of biomedical applications in which the biomaterial can perform as a drug delivery system and bioadhesive [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Functionalization of an Alginate-Based Material by Oxidation and Reductive Amination

Huamani-Palomino

Córdova

et al. 2021

Polymers

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This research focused on the synthesis of a functional alginate-based material via chemical modification processes with two steps: oxidation and reductive amination. In previous alginate functionalization with a target molecule such as cysteine, the starting material was purified and characterized by UV-Vis, 1H-NMR and HSQC. Additionally, the application of FT-IR techniques during each step of alginate functionalization was very useful, since new bands and spiked signals around the pyranose ring (1200–1000 cm−1) and anomeric region (1000–750 cm−1) region were identified by a second derivative. Additionally, the presence of C1-H1 of β-D-mannuronic acid residue as well as C1-H1 of α-L-guluronic acid residue was observed in the FT-IR spectra, including a band at 858 cm−1 with characteristics of the N-H moiety from cysteine. The possibility of attaching cysteine molecules to an alginate backbone by oxidation and post-reductive amination processes was confirmed through 13C-NMR in solid state; a new peak at 99.2 ppm was observed, owing to a hemiacetal group formed in oxidation alginate. Further, the peak at 31.2 ppm demonstrates the presence of carbon -CH2-SH in functionalized alginate—clear evidence that cysteine was successfully attached to the alginate backbone, with 185 μmol of thiol groups per gram polymer estimated in alginate-based material by UV-Visible. Finally, it was observed that guluronic acid residue of alginate are preferentially more affected than mannuronic acid residue in the functionalization.

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“…Biopolymers have been proposed to be a safer alternative to conventional polymers in many biomedical applications such as tissue engineering scaffolds [9,10], drug delivery [11], biosensing [12], wound healing [13], obstetrics, and gynecology [14,15]. The invention pertains to developing new innovational biopolymer-based materials still challenging.…”

Section: Introductionmentioning

confidence: 99%

The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review

et al. 2021

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Biopolymers have gained tremendous attention in many daily life applications, including medical applications, in the past few years. Obstetrics and gynecology are two fields dealing with sensitive parts of the woman’s body and her newborn baby, which are normally associated with many issues such as toxicity, infections, and even gene alterations. Medical professions that use screening, examination, pre, and post-operation materials should benefit from a better understanding of each type of material’s characteristics, health, and even environmental effects. The underlying principles of biopolymer-based materials for different obstetric and gynecologic applications may discover various advantages and benefits of using such materials. This review presents the health impact of conventional polymer-based materials on pregnant women’s health and highlights the potential use of biopolymers as a safer option. The recent works on utilizing different biopolymer-based materials in obstetric and gynecologic are presented in this review, which includes suture materials in obstetric and gynecologic surgeries, cosmetic and personal care products, vaginal health, and drug delivery; as well as a wound dressing and healing materials. This review highlights the main issues and challenges of biopolymers in obstetric and gynecologic applications.

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Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

Cited by 59 publications

References 111 publications

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

Functionalization of an Alginate-Based Material by Oxidation and Reductive Amination

The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review

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