Thiolated sodium alginate/polyethylene glycol/hydroxyapatite nanohybrid for bone tissue engineering

Bhagyasree, K.; Mukherjee, Dhrubojyoti; Azamthulla, Mohammad; Debnath, Shouvik; Sundar, Lakshmi M.; Hulikal, Sahana; Banala, Venkatesh Teja; Bhatt, Shvetank; Kamnoore, Devanand

doi:10.1016/j.jddst.2022.103813

Cited by 11 publications

(6 citation statements)

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“…The alginate-based materials’ capability to incorporate cells and drugs, as well as their promotion of wound healing, highlight them as a promising issue for tissue engineering. Alginate composites, such as alginate–chitosan [ 206 ] or alginate–polyethylene glycol [ 207 ], alginate–biosilica [ 208 ], alginate–ceramics [ 209 ], and alginate–proteins, such as collagen, are known for multiply tissue engineering and medicine applications due to the enhanced cell adhesion, biocompatibility, tensile strength, and porosity [ 210 ]. Biocompatibility and non-toxicity show that alginate can be safely used in the food and cosmetic industries.…”

Section: Discussionmentioning

confidence: 99%

State of Innovation in Alginate-Based Materials

Adamiak

Sionkowska

2023

Marine Drugs

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This review article presents past and current alginate-based materials in each application, showing the widest range of alginate’s usage and development in the past and in recent years. The first segment emphasizes the unique characteristics of alginates and their origin. The second segment sets alginates according to their application based on their features and limitations. Alginate is a polysaccharide and generally occurs as water-soluble sodium alginate. It constitutes hydrophilic and anionic polysaccharides originally extracted from natural brown algae and bacteria. Due to its promising properties, such as gelling, moisture retention, and film-forming, it can be used in environmental protection, cosmetics, medicine, tissue engineering, and the food industry. The comparison of publications with alginate-based products in the field of environmental protection, medicine, food, and cosmetics in scientific articles showed that the greatest number was assigned to the environmental field (30,767) and medicine (24,279), whereas fewer publications were available in cosmetic (5692) and food industries (24,334). Data are provided from the Google Scholar database (including abstract, title, and keywords), accessed in May 2023. In this review, various materials based on alginate are described, showing detailed information on modified composites and their possible usage. Alginate’s application in water remediation and its significant value are highlighted. In this study, existing knowledge is compared, and this paper concludes with its future prospects.

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Section: Discussionmentioning

confidence: 99%

State of Innovation in Alginate-Based Materials

Adamiak

Sionkowska

2023

Marine Drugs

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“…The diffraction peaks of HPMC K4M were detected at because of the molecular level interaction of the polymers with crystalline zinc and hydroxyapatite. The sharp nature of the peaks of the composite with zinc signifies that there could be interaction between -OH groups of HPMC and COOof alginates with Ca 2+ of hydroxyapatite and zinc leading to changes in the atomic density and crystalline composite nature of the material developed (5,37). There was no substantial peak broadening in the diffraction pattern of composite material indicating optimum and restricted crosslinking between the polymers and zinc ions.…”

Section: Ftir and Xrd Analysismentioning

confidence: 98%

“…Nano-based biomaterials are nanostructured bioactive materials that substantially impact biotechnology and biomedicine (2,3). The nanosized particles allow their passage through biological barriers and the biomaterial-based features such as mechanical, optical, electrical, and magnetic properties controlled by quantum effects and biological activity aid in therapeutic efficacy (4,5). Zinc (Zn) is one of the substantial trace elements present in bone tissue (1.5 to 2.5 g and most of it is present in bone and muscles) and has been widely reported to have stimulatory activity in bone growth (6).…”

Section: Introductionmentioning

confidence: 99%

“…Zn-based scaffolds have been reported to have increased extracellular matrix mineralization in mesenchymal stem cell culture by elevating the expression of ALP and osteopontin, which has a substantial role in osteogenesis (9). Sodium alginate is a hydrophilic, anionic polysaccharide having similarities to ECM and is widely used in tissue engineering applications (5). Alginate derivatives are of specific interest as a biomaterial and supporting matrix for tissue regeneration due to their excellent properties of biocompatibility, non-antigenicity, biodegradability, and ability to form chelates.…”

Section: Introductionmentioning

confidence: 99%

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Sodium alginate cross-linked hydroxypropyl methylcellulose/hydroxyapatite nano biomaterial mediated with zinc to promote bone tissue healing

Rudraradhya,

Teja,

Mukherjee

2023

Preprint

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The present study aimed to develop a composite material using sodium alginate and hydroxypropyl methylcellulose in combination with hydroxyapatite. The composite was doped with zinc and developed into a nanocomposite by using ionic gelation and solvent precipitation methods. The prepared nanocomposite was characterized by scanning electron microscopy, atomic force microscopy, dynamic light scattering, FTIR, and XRD studies. In vivo pharmacological studies were carried out to establish the bone targeting and bone tissue regeneration efficacy of the developed nanocomposite. The nanocomposite was checked for cell toxicity by performing an MTT assay using MG63 cell line and the molecular mechanism of targeting efficiency was assessed by in silico evaluation method. The results of the study confirmed the polymeric interlinking in the nanocomposite and the successful preparation of a composite material by using biodegradable excipients. SEM and AFM studies indicated that the nanocomposite was within the 80-200 nm size range. MTT assay indicated that the developed nanocomposite was not cytotoxic and well tolerated by the MG63 cell line. In vivo studies in validation with molecular docking evaluation suggested that the nanocomposite was effectively targeted to the bone as well as had osteogenesis properties by following a mechanism whereby it could effectively block Farnesyl Diphosphate Synthetase in the mevalonate pathway which is essential for inhibiting the osteoclastic activity and promoting osteogenesis.

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“…PEG is a water-soluble, non-ionic, and biodegradable synthetic polymer that has a wide range of applications in TE [ 29 ]. The mechanical properties of composites can be improved by the good mechanical stiffness of PEG [ 30 ]. PEG exhibits low immunogenicity and nontoxicity [ 29 ].…”

Section: Materials Used For 3d Scaffold Engineeringmentioning

confidence: 99%

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Vach Agocsova,

Culenova,

Birova

et al. 2023

Materials

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This article provides a thorough overview of the available resorbable biomaterials appropriate for producing replacements for damaged tissues. In addition, their various properties and application possibilities are discussed as well. Biomaterials are fundamental components in tissue engineering (TE) of scaffolds and play a critical role. They need to exhibit biocompatibility, bioactivity, biodegradability, and non-toxicity, to ensure their ability to function effectively with an appropriate host response. With ongoing research and advancements in biomaterials for medical implants, the objective of this review is to explore recently developed implantable scaffold materials for various tissues. The categorization of biomaterials in this paper includes fossil-based materials (e.g., PCL, PVA, PU, PEG, and PPF), natural or bio-based materials (e.g., HA, PLA, PHB, PHBV, chitosan, fibrin, collagen, starch, and hydrogels), and hybrid biomaterials (e.g., PCL/PLA, PCL/PEG, PLA/PEG, PLA/PHB PCL/collagen, PCL/chitosan, PCL/starch, and PLA/bioceramics). The application of these biomaterials in both hard and soft TE is considered, with a particular focus on their physicochemical, mechanical, and biological properties. Furthermore, the interactions between scaffolds and the host immune system in the context of scaffold-driven tissue regeneration are discussed. Additionally, the article briefly mentions the concept of in situ TE, which leverages the self-renewal capacities of affected tissues and highlights the crucial role played by biopolymer-based scaffolds in this strategy.

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Thiolated sodium alginate/polyethylene glycol/hydroxyapatite nanohybrid for bone tissue engineering

Cited by 11 publications

References 50 publications

State of Innovation in Alginate-Based Materials

State of Innovation in Alginate-Based Materials

Sodium alginate cross-linked hydroxypropyl methylcellulose/hydroxyapatite nano biomaterial mediated with zinc to promote bone tissue healing

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

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