State of Innovation in Alginate-Based Materials

Adamiak, Katarzyna; Sionkowska, Alina

doi:10.3390/md21060353

Cited by 12 publications

(4 citation statements)

References 204 publications

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“…We first analyzed the composition of PURP extract and found that it contained polysaccharides, monosaccharides and proteins (Figure 1A‐D and Figure S1). Barrier repair has been reported in this species, and monosaccharides also have repair and anti‐inflammatory effects 39,47–55 . Here, PURP promoted skin barrier repair, particularly involving members of the claudin family (Figure 2–6, 7I,K, Figure S2a and b).…”

Section: Discussionmentioning

confidence: 56%

“…Barrier repair has been reported in this species, and monosaccharides also have repair and anti-inflammatory effects. 39,[47][48][49][50][51][52][53][54][55] Here, PURP promoted skin barrier repair, particularly involving members of the claudin family (Figure 2-6, 7I,K, Figure S2a and b). We also detected the expression of other genes related to the skin barrier.…”

Section: Discussionmentioning

confidence: 99%

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Prinsepia utilis Royle polysaccharides promote skin barrier repair through the Claudin family

Wang,

et al. 2024

Skin Research and Technology

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BackgroundPlant polysaccharides have various biological activities. However, few studies have been conducted on the skin barrier of Prinsepia utilis Royle polysaccharide extract (PURP).Materials and methodsThe proportions of polysaccharides, monosaccharides and proteins were determined by extracting polysaccharides from fruit meal using water. The healing rate was measured by cell scratch assays. SDS‐damaged reconstructed human epidermal models, an acetone–ether‐induced mouse model and an IL‐4‐induced cellular inflammation model were used to detect the effects of polysaccharides on the phenotype, HA, TEWL, and TEER, with further characterizations performed using QRT‐PCR, Western blotting, immunofluorescence (IF) assays.ResultsPURP contained 35.73% polysaccharides and 11.1% proteins. PURP promoted cell migration and increased skin thickness in a reconstructed human epidermis model. The TEWL significantly decreased, and the HA content significantly increased. PURP significantly increased the TEER and decreased the permeability of the SDS‐damaged reconstructed human epidermis model. Claudin‐3, Claudin‐4, and Claudin‐5 were significantly upregulated. IF and Western blot analysis revealed that the Claudin‐4 level significantly increased after treatment with PURP. Claudin‐1, Claudin‐3, Claudin‐4, and Claudin‐5 gene expression and IF and immunohistochemical staining were significantly increased in mice treated with acetone–ether. PURP promoted the expression of Claudin‐1, Claudin‐3, Claudin‐4, and Claudin‐5 after treatment with 100 ng/mL IL‐4. PURP also downregulated the expression of NO, IL6, TNFα and NFκB in Raw 264.7 cells and in a mouse model.ConclusionWe hypothesize that PURP may repair the skin barrier by promoting the expression of the claudin family and can assist in skin therapy.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Prinsepia utilis Royle polysaccharides promote skin barrier repair through the Claudin family

Wang,

et al. 2024

Skin Research and Technology

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“…Polysaccharides can be easily modified, and this quality improves operational properties of polymer materials and expands their application areas. Sodium alginate (Alg), a widely used anionic polysaccharide, finds numerous applications in biomedicine for drug delivery [7][8][9], the food industry for packaging [10][11][12][13][14], tissue engineering to accelerate wound healing and cell transplantation [7,8,[15][16][17][18], cosmetics as water-retaining agents [19][20][21][22], etc.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol

Novoskoltseva,

Litmanovich,

Loiko

et al. 2023

IJMS

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Biocidal coatings have been used in biomedicine, cosmetology and the food industry. In this article, the coatings are described as being composed of non-stoichiometric polycomplexes, products of electrostatic coupling of two commercial biodegradable ionic polymers, anionic sodium alginate and cationic quaternized hydroxyethyl cellulose ethoxylate. Non-stoichiometric polycomplexes with a 5-fold excess of the cationic polymer were used for immobilizing hydrophobic biocidal 4-hexylresorcinol (HR). Being dispersed in water, the polycomplex particles were capable of absorbing a tenfold excess of HR in relation to the polycation. After deposition onto the plastic surface and drying, the aqueous polycomplex–HR composite formulation forms a transparent homogeneous coating, which swells slightly in water. The interpolyelectrolyte complex (IPEC) is substantially non-toxic. The incorporation of HR in the IPEC imparts antimicrobial activity to the resulting composite, in both aqueous solutions and coatings, against Gram-negative and Gram-positive bacteria and yeast. The polysaccharide-based polycomplexes with embedded HR are promising for the fabrication of biocidal films and coatings.

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“…Sodium alginate, a FDA-approved polysaccharide [ 4 ], is frequently used in the formulation of novel dosage forms due to its excellent biodegradability, biocompatibility, and water solubility features. As shown by Bhosale et al (contribution 3), when sodium alginate is applied to mucoadhesive chitosan nanoparticles, there is an increase in voriconazole loading capacity and in the ability of these nanoparticles to penetrate mucosa.…”

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confidence: 99%