Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution

Shen, Jie; Deng, Yanping; Jin, Xuefeng; Ping, Qineng; Su, Zhigui; Li, Lejun

doi:10.1016/j.ijpharm.2010.10.008

Cited by 102 publications

(39 citation statements)

References 32 publications

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“…Beside its higher loading capacity, NLCs have good biocompatibility, feasibility of scaling-up and ability to control drug release (Tian et al, 2013b). Moreover, recent studies indicated that NLCs could increase the ocular bioavailability and improve the penetration of bioactive compounds into ocular tissues with a good ocular tolerance (Li et al, 2008;Shen et al, 2010aShen et al, , 2010b are still needed to improve the drug delivery efficiency, especially, aiming to prolong the retention time of drug on the corneal surface to some extent (Luo et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Okur

Gökçe

Bozbıyık

et al. 2014

European Journal of Pharmaceutical Sciences

141

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Section: Introductionmentioning

confidence: 99%

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Okur

Gökçe

Bozbıyık

et al. 2014

European Journal of Pharmaceutical Sciences

141

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“…Thiolated LN can be used to enhance muco-adhesion as well [75,76]. Moreover, due to their physico-chemical stability, LN can be included in thermo-gelling medium in order to increase permanence of the formulation in contact with the cornea and avoid drainage from lachrymal fluid [77].…”

Section: Delivery To the Anterior Segment Of The Eyementioning

confidence: 99%

Application of lipid nanoparticles to ocular drug delivery

Battaglia

Serpe

Foglietta

et al. 2016

Expert Opinion on Drug Delivery

117

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Although eye drops are widely used as drug delivery systems for the anterior segment of the eye, they are also associated with poor drug bioavailability due to transient contact time and rapid washout by tearing. Moreover, effective drug delivery to the posterior segment of the eye is challenging, and alternative routes of administration (periocular and intravitreal) are generally needed, the blood-retinal barrier being the major obstacle to systemic drug delivery. Areas covered: Nanotechnology, and especially lipid nanoparticles, can improve the therapeutic efficiency, compliance and safety of ocular drugs, administered via different routes, to both the anterior and posterior segment of the eye. This review highlights the main ocular barriers to drug delivery, as well as the most common eye diseases suitable for pharmacological treatment in which lipid nanoparticles have proved efficacious as alternative delivery systems. Expert opinion: Lipid-based nanocarriers are among the most biocompatible and versatile means for ocular delivery. Mucoadhesion with consequent increase in pre-corneal retention time, and enhanced permeation due to cellular uptake by corneal epithelial cells, are the essential goals for topical lipid nanoparticle delivery. Gene delivery to the retina has shown very promising results after intravitreal administration of lipid nanoparticles as non-viral vectors.

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“…28,29 In vitro release profiles of dirithromycin were investigated in freshly prepared simulated tear fluid (STF) at pH 7.4. [30][31][32] Briefly, spray-dried nanoparticles containing 5.0 mg dirithromycin were put in dialysis bags. Bags were closed tightly from both ends and were immersed in the dissolution medium containing 30 mL STF at 34°C±1°C on a water bath using continuous magnetic stirrer with a stirring rate of 150 rpm.…”

Section: Drug Loading and Encapsulation Efficiency (Ee) Were Calculatmentioning

confidence: 99%

Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

Başaran¹

2017

tjps

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ÖZAmaç: Özellikle gözyaşı üretimi ve kırpma refleksleri gibi gözün koruyucu mekanizmalarına bağlı olarak göze topik olarak uygulanan formülasyonların göz yüzeyinden hızla uzaklaştırılması ve korneal yüzeyden verimsiz absorbsiyonu söz konusu olmaktadır. Prekorneal tutunma süresinin ve korneal permeabilitenin arttırılması ile oküler biyoyararlanımın arttırılmasında kolloidal ilaç taşıyıcı sistemler büyük önem taşımaktadır. Bu çalışmada antibakteriyel etkili bir madde olan diritromisin yüklü Kollidon ® SR yapılı polimerik nanopartiküller şiddetli oküler bakteriyel enfeksiyonların etkin tedavisi amacı ile hazırlanmıştır. Gereç ve Yöntemler: Bu çalışmada diritromisin Kollidon ® SR yapılı polimerik nanopartiküllere püskürterek kurutma yöntemi ile yüklenmiştir. Nanopartiküllerin in vitro karakteristik özellikleri üç farklı ortamda üç ay süresince detaylı olarak incelenmiştir. Bulgular: İn vitro analiz sonuçları parçacıkların üç aylık saklama süresince karakteristik özelliklerini koruduklarını göstermiştir. Sonuç: Kollidon ® SR yapılı polimerik nanopartiküllerin şiddetli oküler bakteriyel enfeksiyonların diritromisin ile tedavisinde oldukça etkili ilaç taşıyıcı sistem adayları olduklarını göstermiştir. Anahtar kelimeler: Diritromisin, Kollidon ® SR, polimerik nanopartiküller, oküler ilaç taşıyıcı sistemler Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon ® SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections. Materials and Methods: In this study, dirithromycin was incorporated into the Kollidon ® SR-based nanoparticles by spray drying method. In vitro characteristic properties were evaluated in detail during the storage period of three months at three different conditions. Results: The results of in vitro analyses revealed that characteristic properties of the particles were remained unchanged during the storage period of three months. Conclusion: Kollidon ® SR-based polymeric nanoparticles are good candidates for drug delivery systems in the treatment of severe ocular bacterial infections with dirithromycin.

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Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution

Cited by 102 publications

References 32 publications

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Application of lipid nanoparticles to ocular drug delivery

Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

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