Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis

“…The EE and DL capacity were calculated according to the following equations 16,28,29 In vitro drug release studies with H 3 PO 4 to pH 6.75) at 37°C±0.5°C, stirred continuously with magnetic stirrer at 300 rpm for 8 hours. The amount of the drug in the receiving solution was analyzed by validated HPLC method.…”

Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis

“…The first one is development of novel ophthalmic drug delivery systems such as microemulsions, microspheres, nanoparticles, liposomes and ocular inserts [12]. It has been shown that ophthalmic drug delivery may benefit from the characteristics of nanotechnology-based drug delivery systems especially solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) [13,14]. Recent studies indicated that SLNs and NLCs could increase the penetration of bioactive agents into ocular tissues and improve the ocular bioavailability with a good ocular tolerance [2, [15][16][17][18].…”

Lipid Nanoparticles for Ocular Drug Delivery

“…They have found that NLCs remained 20-40 min on the eye surface. The longest precorneal retention time was determined with chitosan modified NLCs as 40-60 min [6] . In another recent study the authors prepared NLC based inserts by means of high shear homogenization and 0.75% chitosan oligosaccharide lactate (COL) was added for ocular ofloxacin delivery for treatment of bacterial keratitis.…”

“…A major problem in conventional ophthalmic drug delivery is low drug bioavailability due to ocular anatomical and physiological constraints, which include the poor permeability of cornea, nasolacrimal drainage effect, and short retention time in the precorneal area [3,4] . Excessive liquids, both normally produced and externally delivered, rapidly drain from the eye [5,6] . The approaches to overcome the barriers related to the ophthalmic drug delivery a major aim.…”

“…Numerous drugs, e.g. antibiotics [4,6] , plasmids [15] , antiinflammatory [16] and immuno-suppressive [9] agents, have been loaded into lipid nanoparticles for the treatment of ophthalmic disorders. Puglia et al evaluated lipid nanocarriers for different application fields in ophthalmic treatment [17] .…”