Thiolated hyaluronic acid and catalase-enhanced CD44-targeting and oxygen self-supplying nanoplatforms with photothermal/photodynamic effects against hypoxic breast cancer cells

Wang, Xinyu; Lin, Chi; Chang, Wong-Jin; Huang, Yen‐Hua; Mi, Fwu Long

doi:10.1016/j.ijbiomac.2022.08.164

Cited by 12 publications

(8 citation statements)

References 59 publications

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“…Second, the chemotherapeutic drug SK was loaded into HFM by electrostatic adsorption to obtain HFM@SK. Since previous studies have shown that HA could target tumor cells, the HA modification can make the nanomaterials gather more in the tumor site. − Finally, HA was modified on the surface of HFM@SK to improve the tumor-targeting effect.…”

Section: Resultsmentioning

confidence: 99%

Shikonin-Loaded Hollow Fe-MOF Nanoparticles for Enhanced Microwave Thermal Therapy

Chen,

Zhao,

Ren

et al. 2023

ACS Biomater. Sci. Eng.

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Microwave (MW) thermal therapy has been widely used for the treatment of cancer in clinics, but it still shows limited efficacy and a high recurrence rate owing to non-selective heat delivery and thermo-resistance. Regulating glycolysis shows great promise to improve MW thermal therapy since glycolysis plays an important role in thermoresistance, progression, metabolism, and recurrence. Herein, we developed a delivery nanosystem of shikonin (SK)-loaded and hyaluronic acid (HA)-modified hollow Fe-MOF (HFM), HFM@SK@ HA, as an efficient glycolysis-meditated agent to improve the efficacy of MW thermal therapy. The HFM@SK@HA nanosystem shows a high SK loading capacity of 31.7 wt %. The loaded SK can be effectively released from the HFM@SK@HA under the stimulation of an acidic tumor microenvironment and MW irradiation, overcoming the intrinsically low solubility and severe toxicity of SK. We also find that the HFM@SK@HA can not only greatly improve the heating effect of MW in the tumor site but also mediate MW-enhancing dynamic therapy efficiency by catalyzing the endogenous H 2 O 2 to generate reactive oxygen species (ROS). As such, the MW irradiation treatment in the presence of HFM@SK@HA in vitro enables a highly improved anti-tumor efficacy due to the combined effect of released SK and generated ROS on inhibiting glycolysis in cancer cells. Our in vivo experiments show that the tumor inhibition rate is up to 94.75% ± 3.63% with no obvious recurrence during the 2 weeks after treatment. This work provides a new strategy for improving the efficacy of MW thermal therapy.

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Section: Resultsmentioning

confidence: 99%

Shikonin-Loaded Hollow Fe-MOF Nanoparticles for Enhanced Microwave Thermal Therapy

Chen,

Zhao,

Ren

et al. 2023

ACS Biomater. Sci. Eng.

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“…Although CAT has a wide range of sources and a high activity, its stability in physiological environment is poor as a biological enzyme. How to improve the stability of CAT through safe and effective methods will become a major problem that must be solved in the clinical transformation [36 , 37] .…”

Section: Oxygen-dependent Pdtmentioning

confidence: 99%

“… Strategies Advantages Disadvantages Ref. Hyperbaric oxygen therapy Hostile TME regulation Nanomedicine delivery promotion in solid tumors Increased O 2 supply to cancerous tissue Enhanced side effects of drugs Middle ear barotrauma Possibility of causing oxygen toxicity [17 , 19] Vascular normalization Improvement of blood perfusion at tumor sites Tumor metastasis inhibition Promotion of drug transport Lack of uniform evaluation criteria Lack of widespread clinical application [28 , 29] H 2 O 2 decomposition Catalase H 2 O 2 decomposition in suit to amplify PDT Wide biological source High activity Limited stability within environmental changes and proteases [36 , 37] Nanoenzymes Easy to store Utilization of MnO 2 for MRI-guided PDT Inherent toxicity Incompatibility with cellular enzyme networks Single therapeutic mechanism [149 , 150] Water splitting CaO 2 Ability to induce calcium overload for enhanced tumor therapy Good biocompatibility Unlimited supply of the raw material Simple preparation and low price Relatively slow O 2 release rate Deep-seated tumor treatment enhancement …”

Section: Oxygen-dependent Pdtmentioning

confidence: 99%

Innovative strategies for photodynamic therapy against hypoxic tumor

Chen

Huang

et al. 2023

Asian Journal of Pharmaceutical Sciences

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“…Wang et al synthesized thiolated HA (THA) and catalase modified Ce6-adsorbed small gold nanorods (catalase/THA-Ce6@sAuNRs), which maintained the excellent enzymatic activity of catalase for self-supporting O 2 production. 242 The photosensitizer Ce6's intracellular accumulation was dramatically increased after Ce6@sAuNRs were modified with THA. Meanwhile, catalase endows the nanomaterial with selfsupporting O 2 production for efficient 1 O 2 generation under 660 nm laser irradiation.…”

Section: Hypoxia-relieving Strategies Based On Nanomedicinementioning

confidence: 99%

“…Since collagen is abundant in various tissues, thus has the potential to become a promising enzyme delivery platform with amplified delivery efficiency, and therapeutic efficacy. Wang et al synthesized thiolated HA (THA) and catalase modified Ce6-adsorbed small gold nanorods (catalase/THA-Ce6@sAuNRs), which maintained the excellent enzymatic activity of catalase for self-supporting O 2 production . The photosensitizer Ce6’s intracellular accumulation was dramatically increased after Ce6@sAuNRs were modified with THA.…”

Section: Hypoxia-relieving Strategies Based On Nanomedicinementioning

confidence: 99%

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Pan,

Liu,

Mou

et al. 2023

ACS Nano

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Cancer with a complex pathological process is a major disease to human welfare. Due to the imbalance between oxygen (O 2 ) supply and consumption, hypoxia is a natural characteristic of most solid tumors and an important obstacle for cancer therapy, which is closely related to tumor proliferation, metastasis, and invasion. Various strategies to exploit the feature of tumor hypoxia have been developed in the past decade, which can be used to alleviate tumor hypoxia, or utilize the hypoxia for targeted delivery and diagnostic imaging. The strategies to alleviate tumor hypoxia include delivering O 2 , in situ O 2 generation, reprogramming the tumor vascular system, decreasing O 2 consumption, and inhibiting HIF-1 related pathways. On the other side, hypoxia can also be utilized for hypoxia-responsive chemical construction and hypoxia-active prodrug-based strategies. Taking advantage of hypoxia in the tumor region, a number of methods have been applied to identify and keep track of changes in tumor hypoxia. Herein, we thoroughly review the recent progress of nanomedicine strategies in both conquering and utilizing hypoxia to combat cancer and put forward the prospect of emerging nanomaterials for future clinical transformation, which hopes to provide perspectives in nanomaterials design.

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Thiolated hyaluronic acid and catalase-enhanced CD44-targeting and oxygen self-supplying nanoplatforms with photothermal/photodynamic effects against hypoxic breast cancer cells

Cited by 12 publications

References 59 publications

Shikonin-Loaded Hollow Fe-MOF Nanoparticles for Enhanced Microwave Thermal Therapy

Shikonin-Loaded Hollow Fe-MOF Nanoparticles for Enhanced Microwave Thermal Therapy

Innovative strategies for photodynamic therapy against hypoxic tumor

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

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