Thiolated Chitosans: Novel Polymers for Mucoadhesive Drug Delivery – A Review

Sreenivas, S. A.; Pai, K Girish

doi:10.4314/tjpr.v7i3.14694

Cited by 58 publications

(37 citation statements)

References 51 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The enhancement of mucoadhesion can be explained by the formation of covalent bonds between the polymer and the mucus layer which are stronger than non-covalent bonds. This theory was supported by the results of assessment of Mucoadhesive strength demonstrated a positive correlation between the degree of modification with thiol bearing moieties and the adhesive properties of the polymer (Sreenivas and Pai, 2008;Deshmane et al, 2009). For the measurement of the Mucoadhesive strength, the pure polymer was taken and the disc of 150 mg was prepared by using 8 mm die on the rotary compression machine.…”

Section: Mucoadhesivity Assessmentmentioning

confidence: 79%

“…Due to bulkier aromatic group it provided hindrance to the thiol group to immobilize on primary amino group of chitosan. The resultant thiolated polymer derivatives have shown good swelling property and enhanced mucoadhesive strength due to the intermolecular disulphide linkage between the polymer and mucosa (Sreenivas and Pai, 2008;Deshmane et al, 2009) (Fig. 4).…”

Section: Resultsmentioning

confidence: 95%

“…The cohesion and stability of a drug delivery system over the intended duration of drug liberation is often a substantial requirement for a controlled release. The usefulness of Thiolated Chitosans as carrier matrices for controlled drug release was demonstrated with model drug as Amodiaquine (Sreenivas and Pai, 2008) (Table 4).…”

Section: Thiol Derivative As Controlled Release Matrixmentioning

confidence: 99%

“…Further, some chitosan conjugates with thiol containing moieties have shown promising swelling property in alkaline pH (Irene and Christine, 2007;Sreenivas and Pai, 2008). This article deals with synthesis of some novel derivatives of chitosan possessing thiol functional group obtained in stepwise reaction.…”

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Controlled release matrix tablet formulation using synthesized N-acyl Thiolated Chitosan derivatives

Sonone¹,

Kokane²,

Shirote³

et al. 2019

Arabian Journal of Chemistry

View full text Add to dashboard Cite

Chitosan derivative was successively synthesized by initial preparation of acyl thiourea reagent using ammonium thiocyanate and making it to react with at primary amino groups of chitosan and then reduced to yield Thiolated Chitosan. Due to the formation of disulphide bonds with mFucus glycoproteins, mucoadhesiveness is augmented. The thiol groups were then quantified using Ellman's reagent. The derivatives inherit good swelling property in neutral and alkaline media. The different derivatives containing thiol groups were formulated into tablets using reference drug for evaluation. The Thiolated Chitosan display in situ gelling features due to the pHdependent (alkaline pH) formation of inter-molecular disulphide bonds which makes the application of Thiolated Chitosan on intestinal mucosa and can guarantee prolonged controlled release of embedded therapeutic ingredients. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

show abstract

Section: Mucoadhesivity Assessmentmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 95%

Section: Thiol Derivative As Controlled Release Matrixmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Controlled release matrix tablet formulation using synthesized N-acyl Thiolated Chitosan derivatives

Sonone¹,

Kokane²,

Shirote³

et al. 2019

Arabian Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…The CS-TGA conjugate exhibited 236 ± 26 µmol thiol groups per gram of polymer. A degree of modification of 25-250 mmol thiol groups per gram of chitosan leads to the highest improvement in the mucoadhesive and permeation enhancing properties of these thiolated chitosans (Sreenivas and Pai, 2009). …”

Section: Results and Discussion Chitosan-4-thioglycolic Acid (Cs-tga)mentioning

confidence: 99%

Development and Evaluation of Lyophilized Thiolated-Chitosan Wafers for Buccal Delivery of Protein

Ayensu

Boateng

2012

Jnl Sci Tech

View full text Add to dashboard Cite

Annealed and non-annealed freeze-dried wafers from synthesised thiolated-chitosan have been developed and evaluated. Wafers were obtained by freeze-drying aqueous gels of the thiolated polymer incorporating per polymer weight, 10 % each of glycerol as plasticizer, D-mannitol as cryoprotectant and 50% BSA as model protein drug. The formulation was freeze-dried with or without the process of annealing. Texture analyzer was employed to investigate the in vitro mucoadhesive properties in tensile mode, residual moisture content by thermo-gravimetric analysis (TGA) while hydration capacity and drug release studies were performed in 0.1M PBS. Microscopic architecture was examined using scanning electron microscopy (SEM). Differential scanning calorimetry (DSC) was employed for protein phase separation studies and conformational stability by attenuated total reflectance-Fourier transform infra-red spectroscopy (ATR-FTIR) and confirmed with Circular dichroism (CD). The annealing process led to wafers with increased ease of hydration, improved in vitro mucoadhesive characteristics and enhanced BSA release, without affecting the conformational stability of the protein due to the presence of a cryoprotectant. These results show the potential application of annealed freeze-dried thiolatedchitosan wafers for buccal mucosa delivery of protein based drugs.

show abstract

Marine Biomaterials‐Based Systems

Jana

Gandhi²,

Roy³

2020

Encyclopedia of Marine Biotechnology

View full text Add to dashboard Cite

Thiolated Chitosans: Novel Polymers for Mucoadhesive Drug Delivery – A Review

Abstract: Chitosan is a natural polycationic copolymer consisting of glucosamine and N-acetylglucosamine units. The polymer has valuable properties as a biomaterial because it is

Cited by 58 publications

References 51 publications

Controlled release matrix tablet formulation using synthesized N-acyl Thiolated Chitosan derivatives

Controlled release matrix tablet formulation using synthesized N-acyl Thiolated Chitosan derivatives

Development and Evaluation of Lyophilized Thiolated-Chitosan Wafers for Buccal Delivery of Protein

Marine Biomaterials‐Based Systems

Contact Info

Product

Resources

About